Preparation method and application of combination of tumor antigen-targeting antibody and iNKT cell

A tumor antigen and antibody technology, applied in the field of test kits and their preparation, can solve the problems of opportunistic infection, harm to patient treatment, and decreased treatment effect, etc.

Pending Publication Date: 2020-05-19
SHANGHAI SINOBAY BIOTECH CO LTD
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Problems solved by technology

[0008] For most tumors, such as CD20-positive diffuse large B-cell lymphoma, treatment with its targeted antibody alone can increase the cure of the tumor; however, due to the immunodeficiency nature of AIDS patients, this further increases the suppression of humoral immunity in patients , thus causing the occurrence of opportunistic infections, which is harmful to the treatment of patients
Therefore, the dosage of targeted antibody drugs needs to be appropriate, which will lead to a decrease in the therapeutic effect
[0009] How to solve the immunogenicity of antibody drugs themselves, such as anti-drug antibody (anti-drug antibody, ADA) reaction, the tolerance of long-term use of tumor targets, and the long-term effect of a single blockade of signal transduction pathways, is an important issue for tumors. Unavoidable challenges for antibody drugs

Method used

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  • Preparation method and application of combination of tumor antigen-targeting antibody and iNKT cell
  • Preparation method and application of combination of tumor antigen-targeting antibody and iNKT cell
  • Preparation method and application of combination of tumor antigen-targeting antibody and iNKT cell

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Embodiment 1

[0066] The clinical treatment course, result and conclusion of the combination of embodiment 1 of the present invention

[0067] 1. Clinical treatment process

[0068] 1.1 The patient's clinical diagnosis

[0069] The patient found an abdominal mass without redness, swelling and pain, and accompanied by fever; the biopsy diagnosis was: diffuse large B-cell lymphoma and human immunodeficiency virus (HIV) positive ( figure 1 ).

[0070] 1.2 Conventional treatment plan for patients

[0071] After the patient's condition was diagnosed, the patient was treated with tenofovir / emtricitabine + dolutegravir for AIDS (Acquired Immune Deficiency Syndrome, AIDS). One month later, on July 5, 2018, R-EPOCH (rituximab, doxorubicin, vincristine and etoposide, in which three chemotherapy drugs, doxorubicin, vincristine and etoposide were injected together It takes 96 hours of uninterrupted treatment (one chemotherapy drug, one bag a day, a total of four bags), and finally vincristine (the...

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Abstract

The invention provides application of a combination of a tumor antigen-targeting antibody and an immune cell iNKT in preparation of anti-tumor drugs. The invention also provides a preparation method of the combination. The iNKT cell is adopted as an effector cell of the combination, and the tumor antigen-targeting antibody and the iNKT cell are combined, so that higher killing activity on tumor target cells is obtained, and the anti-tumor ability is further improved.

Description

technical field [0001] The invention relates to the field of tumor immunotherapy. Specifically, the present invention relates to the use of the combination of antibodies targeting tumor antigens and iNKT cells, a kit for immunotherapy of tumors using the combination of antibodies targeting tumor antigens and iNKT cells, and their preparation methods. Background technique [0002] Tumor immunotherapy can target tumor-induced immune escape and immunosuppressive tumor microenvironment, enhance the body's anti-tumor immune response by activating immune cells in the body, specifically clear tumor lesions, inhibit tumor growth, and break immune resistance. by. Due to its low side effects and obvious therapeutic effect, tumor immunotherapy is known as the fourth major tumor treatment technology after tumor surgery, radiotherapy and chemotherapy. In December 2013, tumor immunotherapy was ranked first among the top ten scientific research breakthroughs in the world by Science magaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K35/17A61P35/00C12N5/0783
CPCA61K35/17A61K39/3955A61K9/0019A61P35/00C12N5/0646A61K2039/505C12N2502/1121C12N2502/11C12N2501/999C12N2501/2302C12N2501/2307C12N2501/2315A61K2300/00
Inventor 徐建青张晓燕丁相卿廖启彬王婧
Owner SHANGHAI SINOBAY BIOTECH CO LTD
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