Unlock instant, AI-driven research and patent intelligence for your innovation.

Mannitol eutectic auxiliary material and its preparation method and application

A technology of mannitol and mannitol complex is applied in the complex of mannitol and calcium chloride and the field of preparation thereof, and can solve the problems of low hygroscopicity and compressibility, mannitol compressibility and strong hygroscopicity of calcium chloride.

Active Publication Date: 2022-04-05
CHINA PHARM UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This application uses a non-chemical synthesis method to obtain a complex of mannitol and calcium chloride (also known as mannitol eutectic excipient), which has good water solubility, low hygroscopicity and good compressibility , overcome the defects of poor compressibility of mannitol and strong hygroscopicity of calcium chloride, and can be used as a new type of pharmaceutical excipient in oral solid preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mannitol eutectic auxiliary material and its preparation method and application
  • Mannitol eutectic auxiliary material and its preparation method and application
  • Mannitol eutectic auxiliary material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: the preparation of mannitol calcium chloride co-crystal

[0077] Add 1.82g of mannitol and 1.11g of anhydrous calcium chloride into 10mL of water, dissolve at room temperature to obtain a clear solution, evaporate the solvent at 80°C to obtain a crystal product after 7 days, filter it with suction, and dry it in vacuum at 25°C for 12 hours to obtain manna Alcohol Calcium Chloride Eutectic.

[0078] The obtained mannitol calcium chloride cocrystal is characterized by powder X-ray diffraction, infrared spectroscopy and differential scanning calorimetry (DSC), and the powder-ray diffraction analysis results are shown in the appendix figure 2 , see the results of infrared analysis image 3 , the results of differential scanning calorimetry analysis are shown in the appendix Figure 4 .

Embodiment 2

[0079] Embodiment 2: the preparation of mannitol calcium chloride co-crystal

[0080] Add 1.82g of mannitol and 1.11g of anhydrous calcium chloride into 20mL of 80% ethanol, heat and dissolve at 60°C to obtain a clear solution, evaporate the solvent at 40°C to obtain a crystal product after 3 days, filter it with suction, and dry it under vacuum at 25°C After 12 hours, the mannitol calcium chloride co-crystal was obtained.

Embodiment 3

[0081] Embodiment 3: the preparation of mannitol calcium chloride co-crystal

[0082] Add 18.24g of mannitol and 11.11g of anhydrous calcium chloride into 20mL of water, dissolve to obtain a clear solution, add 200mL of ethanol to the clear solution under stirring, continue to stir to obtain a white solid product, filter it with suction, and dry it in vacuum at 25°C for 12h to obtain manna Alcohol Calcium Chloride Eutectic.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
diffraction angleaaaaaaaaaa
Login to View More

Abstract

The application discloses a mannitol eutectic auxiliary material, which contains mannitol and calcium chloride. In addition, the preparation method and application of the eutectic auxiliary material are also disclosed. The eutectic adjuvant of the present application improves the compressibility of mannitol and significantly improves the hygroscopicity of calcium chloride.

Description

technical field [0001] This application includes but is not limited to the field of medical technology, and specifically relates to but is not limited to the complex of mannitol and calcium chloride and its preparation method and application. Background technique [0002] Mannitol, the chemical formula is C 6 h 14 o 6 , is a natural source of sugar alcohol, which has a very wide range of applications in the field of medicine: mannitol is a good diuretic in medicine, and can be used to reduce intracranial pressure and intraocular pressure; mannitol can be used as an excipient for tablets. Mannitol has no hygroscopicity, fast drying, good chemical stability, and has the characteristics of refreshing and granulation, and is suitable for most tablets; moreover, mannitol absorbs heat when dissolved, and has a sweet taste. It has a comfortable feeling to the mouth, so it is widely used in the manufacture of chewable tablets. However, when mannitol is used as a tablet filler, i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/26A61K47/02
CPCA61K47/26A61K47/02
Inventor 高缘程豪王世茹张建军
Owner CHINA PHARM UNIV