168 results about "Carcainium Chloride" patented technology

The invention discloses an in-situ crosslinking-self-degradation high-strength gel temporary plugging agent and a preparation method thereof, and belongs to the technical field of oil-gas field development. The gel temporary plugging agent is prepared from the following substances in parts by weight: 0.33 to 2.33 parts of polyvinyl alcohol, 0.67 to 4.67 parts of corn amylopectin, 2.8 to 7.0 parts of acrylamide, 1.2 to 3.0 parts of N-vinyl pyrrolidone, 0.05 to 1.05 parts of a cross-linking agent, 0.001 to 0.06 part of an initiator, 0.3 to 2.1 parts of glycerol, 0.02 to 0.14 part of calcium chloride and the balance of water, and the sum of the parts by weight of the substances is 100 parts. The preparation method is simple and convenient to operate, raw materials are low in price and easy to obtain, the preparation process is controllable, and huge industrial popularization prospects are shown. The gel temporary plugging agent is used for a reservoir temporary plugging steering process, can be self-degraded under the condition of constant temperature of a stratum, and has important significance for realizing efficient development of an oil field and improving the oil and gas recovery ratio.

The invention relates to the technical field of biomedical materials, and provides a preparation method and application of cross-linked carboxymethyl cellulose. The preparation method comprises the following steps: S1, dissolving anhydrous calcium chloride in absolute ethyl alcohol, sterilizing and filtering to obtain a sterile calcium chloride solution; s2, adding the dehydrated and purified sodium carboxymethyl cellulose into a sterile calcium chloride solution, and stirring for reaction; s3, after the reaction is finished, suction filtration is performed, filter residues are collected and washed, residual calcium chloride is removed, then vacuum drying is performed, and cross-linked carboxymethyl cellulose is obtained. The cross-linked carboxymethyl cellulose and sodium carboxymethyl cellulose have high consistency in chemical activity, physiological and biochemical activity, biocompatibility and safety risk, but in physical performance, the cross-linked carboxymethyl cellulose is hydrogel fiber, is insoluble in water, can more remarkably maintain the volume of a filling part, and is longer in duration time, so that the cross-linked carboxymethyl cellulose is more stable in filling. And the effects of instant filling and long-acting filling of the microsphere-containing surface filling agent are realized.

The invention provides a pharmaceutical composition, glycyrrhizic acid and polymyxin B self-assembled carrier-free hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a pharmaceutical composition. The pharmaceutical composition comprises glycyrrhizic acid and polymyxin B. According to the pharmaceutical composition, the inhibition effect on MRSA is enhanced through drug combination, the use of polymyxin B is reduced through the synergistic effect, and the development pressure of antibiotic drug resistance is relieved. According to the hydrogel formed by crosslinking the glycyrrhizic acid and the calcium chloride, the glycyrrhizic acid and the calcium chloride are crosslinked to form the hydrogel, and the calcium chloride is introduced into a glycyrrhizic acid system to increase the mechanical strength of the glycyrrhizic acid hydrogel, so that the glycyrrhizic acid hydrogel can be better attached to a wound. The invention provides a glycyrrhizic acid and polymyxin B self-assembled carrier-free hydrogel and a preparation method of the glycyrrhizic acid and polymyxin B self-assembled carrier-free hydrogel. The hydrogel does not contain any inert carrier component at all, the drug loading rate of 100% is achieved, and adverse reactions possibly caused by a traditional carrier system are effectively avoided.

The invention relates to the technical field of biological materials, in particular to a PDRN porous microsphere as well as a preparation method and application thereof. The PDRN porous microspheres are prepared from the following raw materials: PDRN, an oil phase matrix, a curing agent and metal salt, the curing agent is at least one of polyethylene glycol acrylate and polylysine; the metal salt is at least one of calcium chloride, zinc chloride, magnesium chloride and ferric chloride. The PDRN porous microsphere has the advantages of being controllable in size, excellent in disintegration resistance and excellent in swelling resistance, is high in moist heat sterilization tolerance and strength, can be used as a filling material for medical beauty or an ideal candidate material of a tissue engineering scaffold, and has potential application value.

The invention discloses a composite inducer for promoting adhesion and metamorphosis of marine bivalve mollusk larvae and an application method of the composite inducer. The composite inducer for promoting adhesion and metamorphosis of the marine bivalve mollusk larvae comprises glutamine, glutamic acid, potassium chloride, calcium chloride and taurine, and the concentration ratio of the glutamine to the glutamic acid to the potassium chloride to the calcium chloride to the taurine is 1: 1: 2 * 10: 1.7 * 10: 4. According to the application, glutamine, potassium ions, calcium ions, glutamic acid and taurine are matched, the application effect of the glutamine, the potassium ions, the calcium ions, the glutamic acid and the taurine in the aspect of improving the attachment and metamorphosis rate of the shellfish larvae is defined, the technical blank of multi-component cooperative regulation and control of the attachment and metamorphosis of the shellfish at present is filled, a new solution is provided for bivalve shellfish fry production, and the application prospect is wide. The method is of great significance in promoting healthy development of the mariculture industry.

The invention provides a preparation for blood purification and a preparation method and application thereof.The preparation is in a solid state or a liquid state, L-malic acid serves as a pH regulator of the preparation, calcium citrate and calcium chloride are used for providing total calcium, the total calcium addition value of the preparation is 1.0-1.5 mmol / L, and the total calcium addition value of the preparation is 1.0-1.5 mmol / L. A dialysate for clinical application of the preparation contains ionized calcium and molecular calcium at the same time, the molar concentration ratio of the ionized calcium to the molecular calcium is 2-6, the ratio of the total calcium addition value to the molar concentration of the citrate radical is 10-12, the molar concentration ratio of the citrate radical to the L-malic acid is 0.05-0.15, and the molar concentration ratio of the citric acid radical to the L-malic acid is 0.05-0.15. The calcium chloride, the calcium citrate and the L-malic acid are reasonably proportioned, so that the supply of 80-85% of effective free calcium can be realized on the premise of ensuring a low total calcium addition value, thereby obviously reducing adverse reactions caused by low calcium or high calcium in the dialysis process, and effectively preventing and controlling dialysis syndromes and the problem of calcium ion disorder possibly occurring after dialysis.

The invention discloses a preparation method and application of two chemical crosslinking type injectable hemostatic sealant. According to the invention, four-arm polyethylene glycol succinimide glutaric acid ester (TPEG-SG) and carboxymethyl chitosan (CMCS) are taken as main materials, and calcium chloride is added or not added, so that two injectable hemostatic sealing adhesives with chemical crosslinking characteristics are designed and prepared. After the two kinds of sealant are injected to a bleeding part, rapid and efficient gelation and tissue adhesion can be achieved through chemical crosslinking of carboxyl activating groups of the four-arm polyethylene glycol succinimide glutaric acid ester, amino groups in carboxymethyl chitosan and amino groups on the surface of tissue, and therefore wounds are effectively sealed. Compared with a traditional hemostatic material, the two sealing glues have the characteristics of rapid in-situ wound formation, strong tissue adhesion, rapid hemostasis and the like, the problems of poor adhesion performance and poor hemostasis capability of a conventional hemostatic material are solved, and the hemostatic material is more suitable for hemostasis of non-compressible hemorrhage in a special wound environment and has good clinical and military application prospects.

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

The invention discloses a method for adjusting the pore opening degree of Shanghai green, and belongs to the technical field of plant detection. Shanghai leaves are placed in 20mL of open liquid containing (1) 0.5% potassium chloride and 100 [mu] M / L calcium chloride or (2) 0.5% potassium chloride and 50 [mu] M / L brassinolide or (3) 0.5% potassium chloride and 10 [mu] M / L cytokinin or (4) 0.5% potassium chloride and 5 [mu] M / L gibberellin or (5) 0.5% potassium chloride and 100 [mu] M / L methyl jasmonate, culture is performed under illumination, and the illumination time is set to be 5h, so that the pore opening degree of Shanghai is remarkably increased. Compared with a control group (containing 0.5% of potassium chloride), the pore openness of the treatment is respectively increased by 33.5%, 43.5%, 43.4%, 27.1% and 70.2%. The method disclosed by the invention lays a technical foundation for rapidly screening out the exogenous environmental stimulation factor (environical stimuli) capable of increasing the opening degree of the pore.

The invention discloses a water body composite phosphorus locking agent and a preparation method thereof, and belongs to the technical field of water quality treatment. The composite phosphorus locking agent for the water body comprises the following raw material components in parts by weight: 0.5-1.5 parts by mass of modified zirconium hydroxide, 4 parts by mass of sodium alginate, 2.3-2.5 parts by mass of a composite organic material, 6 parts by mass of calcium chloride and 1-3 parts by mass of ferric trichloride, the modified zirconium hydroxide is obtained by modifying zirconium hydroxide with epoxy chloropropane; the composite organic material is prepared from diethanol amine and chitosan; the water body composite phosphorus locking agent prepared by the method is relatively high in phosphorus removal rate.

The invention discloses a composition for relieving, repairing and promoting skin regeneration as well as a preparation method and application of the composition. The composition is prepared from the following raw materials in parts by weight: 0.1 to 5 parts of mandelic acid, 0.5 to 10 parts of a cynanchum atratum extract, 1 to 8 parts of a xylitol compound, 0.5 to 15 parts of regenerated silicon, 1 to 10 parts of a starfish regeneration repair factor, 0.3 to 1.5 parts of trimethylolpropane tri (3-mercaptopropionic acid) ester, 0.05 to 0.5 part of calcium chloride, 0.1 to 1 part of an additive, 0.2 to 2 parts of chitosan-polycaprolactone, 0.2 to 1 part of a pH regulator and 5 to 15 parts of a solvent. 0.3 to 0.8 part of an antioxidant and 3 to 10 parts of a humectant; the additive is hyaluronic acid or formylated hyaluronic acid. Through a multi-channel synergistic effect, the effects of relieving, repairing and promoting skin regeneration are improved.

The invention relates to a calcium chloride injection and a production method thereof, and relates to the technical field of calcium chloride injection production, a solvent of the calcium chloride is water for injection, and the injection contains the following components: 80-120 g / L of calcium chloride; the concentration of the water for injection is 800-1200 g / L; hydrochloric acid is a proper amount of component for adjusting the pH value to 5.3-5.8; and the sodium hydroxide is a proper amount of component used for adjusting the pH value to 5.3-5.8. According to the calcium chloride injection and the production method thereof, the problems of solution turbidity, calcium ion precipitation, oxidative degradation and the like caused by insufficient dissolution and local supersaturation of calcium chloride in the prior art are effectively solved by accurately controlling the concentration of calcium chloride and adopting a nitrogen protection dissolution process. Meanwhile, a 0.22 mu m polyethersulfone two-stage filter element series connection filtering process, an integrity testing process with the foaming point larger than or equal to 3450 kPa and a sterilization and leak detection integrated process are adopted, the sterility guarantee level and stability of the product are remarkably improved, the endotoxin of the finished product is smaller than 0.5 EU / mL, the number of visible foreign matter larger than or equal to 10 mu m is reduced by larger than or equal to 60%, and the clinical safety and effectiveness of the injection are ensured.

The invention discloses a cell protection solution for venous transfusion as well as a preparation method and application of the cell protection solution. The cell protection liquid comprises 4 to 8 mg / ml of sodium chloride, 0.1 to 0.5 mg / ml of potassium chloride, 2.8 to 3.5 mg / ml of sodium lactate, 0.1 to 0.3 mg / ml of calcium chloride, 0.15 to 0.3 [mu] g / ml of glucose, 0.01 to 0.03 ml / ml of 20% human serum albumin, 4 to 8 [mu] g / ml of vitamin E, 0.2 to 2 [mu] g / ml of vitamin B12, 0.5 to 2 [mu] g / ml of folic acid, 4 to 8 [mu] g / ml of L-aspartic acid and 0.5 to 2 [mu] g / ml of glutathione. The cell preserving fluid provided by the invention can effectively protect cells for a long time, can be directly transfused back through veins, does not need special treatment, is convenient for clinical application, and has better application prospect and development potential in the development of the clinical treatment of the cells towards the drug direction.

The invention provides a fosfomycin calcium salt preparation process, and particularly relates to the field of medicines. The preparation method comprises the following steps: mixing water and ethanol to obtain a mixed solution, adding 200-220g of a fosfomycin intermediate into the mixed solution, adding 3-4g of talcum powder, heating to 80-85 DEG C, filtering to obtain a filter cake, washing the filter cake by using 20mL of ice ethanol, heating to 85 DEG C, and drying for 2 hours to obtain DL-salt; uniformly mixing 20-25g of sodium hydroxide and 70mL of purified water, adding 65-70g of DL-salt, heating to 60 DEG C, uniformly mixing, cooling to 45-50 DEG C, and standing for 1.5-2 hours to obtain a lower-layer separation solution; the preparation method comprises the following steps: uniformly mixing 35-40g of calcium chloride and 100mL of purified water, adding 3-4g of talcum powder, standing for 30 minutes, filtering, and adjusting the pH value to 4.8-5 to obtain a calcium chloride solution; and adding 600-650ml of purified water into the lower-layer separation liquid, heating to 65-70 DEG C, adding a calcium chloride solution, filtering, washing with distilled water until no washing liquid drips, and drying at 60-65 DEG C for 1 hour to obtain a finished product. The method is high in yield, simple in step and beneficial to improvement of production efficiency and reduction of production cost.

The invention discloses a method for enhancing adhesion ability of coral larvae after enhancement and release. According to the method, coral larvae (such as coral plankton larvae) are exposed to a 40 mM calcium chloride (CaCl2) solution to be treated for 12-24 hours, and then enhancement and release are carried out. The treated larvae show remarkably enhanced adhesion ability after releasing, the accumulated adhesion rate within 3 days reaches 66.33% and is increased by 240% compared with that of a control group in the same period, and the average survival rate reaches 98.14%. Meanwhile, the transverse growth area and the budding number of attached larvae are remarkably increased, and the density of zooxanthellae, the photosynthetic efficiency and the chlorophyll content have no negative effects. The CaCl2 solution is used for successfully inducing the continuous attachment effect of the coral larvae, the method is easy and convenient to operate, low in cost and environmentally friendly, the attachment success rate of enhancement and release of the coral larvae and the subsequent growth performance of the larvae are remarkably increased, and the method is suitable for repairing and protecting a coral reef ecological system.

This invention relates to the field of biomaterial preparation technology, and in particular to a morphology-controllable mesoporous hydroxyapatite nanosphere, its preparation method, and its applications. The preparation method includes: S1, mixing an aqueous solution of pyridoxal phosphate with an aqueous solution of calcium chloride, adjusting the pH of the mixed solution to 7-11 to obtain a precursor solution; S2, placing the precursor solution in a microwave reactor for reaction to obtain mesoporous hydroxyapatite nanospheres. The preparation method provided by this invention is simple, the reaction conditions are easily controlled, and it is highly safe and reliable. It enables precise control of the morphology and particle size of the hydroxyapatite microspheres, and the prepared product exhibits excellent biocompatibility and structural regularity. It has good industrial application prospects in the field of biomedical implants such as bone tissue repair and is suitable for large-scale production.

The invention relates to a magnesium- aluminium layered double hydroxide (Mg-Al LDH) based filler product comprising boron and functionalised with phosphocholine chloride calcium salt tetrahydrate (PC), the synthesis method of this filler product, and obtaining a new material by preparing a composite material of this filler product, which has antibacterial activity, with a thermoplastic polymer or thermosetting polymer. In the production of the composite material that is the subject of the invention, as the polymer, preferably unsaturated polyester resin (DPes) is used. The composite material comprising the filler product of the invention has the feature of preventing bacterial adhesion / biofilm formation. Said material has the potential to be used for various applications, including medical devices, industrial processes, food production, storage and sales areas, food contact surfaces, areas requiring cleaning and hygiene, and different surface materials.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

This invention discloses a biological reinforcement and corrosion protection process for bridge pier cracks, comprising: S1, extracting calcium ions from South China Sea calcareous sand to obtain a calcium chloride solution; S2, installing a reaction sleeve mold reaction device at the location of the cracked bridge pier, filling the gap between the bridge pier and the mold reaction device with South China Sea calcareous sand particles in three batches, and injecting bacterial solution, urea, and the calcium chloride solution obtained in step S1 in batches for cyclic infusion, and repeating the cyclic infusion process. This invention, by using the calcium chloride solution extracted from South China Sea calcareous sand and the bacterial solution for cyclic infusion, can achieve biological reinforcement of bridge pier cracks, resulting in better compatibility and permeability with the bridge pier substrate material. It can penetrate even the smallest cracks, and the generated calcium carbonate crystals can effectively and better bond with the bridge pier substrate material, playing a role in filling and bonding cracks. It also has the advantages of low cost, convenient material sourcing, few and safe byproducts, and no pollution to the marine environment.

The invention discloses haemostatic and anti-infection bifunctional algal glue and a preparation method thereof. The phycocolloid is prepared from phycocyanin, sodium alginate, polydopamine-piperidine nanoparticles, calcium chloride and water / ethanol. The preparation method comprises the following steps: reacting 2, 2, 6, 6-tetramethylpiperidine oxide with dopamine hydrochloride to prepare polydopamine-piperidine nanoparticles; the preparation method comprises the following steps: fully dissolving phycocyanin, sodium alginate and polydopamine-piperidine nanoparticles in a water / ethanol mixed solution; and adding an isometric calcium chloride aqueous solution, and stirring at room temperature to prepare the haemostatic and anti-infection bifunctional algal glue. The ratio of phycocyanin to sodium alginate is adjusted, the phycocyanin accounts for 1%-10% by weight, the sodium alginate accounts for 1%-5% by weight, different rheological properties and shape maintenance properties are obtained, the content of the nano polydopamine-piperidine compound is adjusted, the weight fraction is 0.1%-0.5%, the photo-thermal sterilization performance is obtained, and the photo-thermal sterilization effect is good. Therefore, the problem of repeated wound infection can be solved only through illumination.

The application discloses an environment-friendly scale inhibitor for a boiler and a preparation method thereof. According to weight parts, the scale inhibitor comprises the following raw materials: 25-35 parts of a branched corrosion and scale inhibitor, 30-40 parts of polyvinyl alcohol, 17-24 parts of sodium alginate, 3-7 parts of glutaraldehyde, 5-10 parts of calcium chloride and 1000-2100 parts of water. The scale inhibitor has good corrosion and scale inhibition effects, and can effectively prolong the service life of the boiler.

Hydration of a larynx and / or vicinity with a composition comprising a salt formulation (e.g., CaCl2, MgCl2, KCl and / or NaCl) can achieve prophylactic and / or therapeutic effects (e.g., cough suppression, improving voice quality, increasing pulse oxygen saturation and / or increasing mucosal vaccination effectiveness). The composition is administered as dry particles (e.g., aerosol) or as a liquid (e.g., solution, aerosol). The liquid can have a pH of 7.0 up to around 10.0, or preferably around 7.5 up to around 9.5, or more preferably around 8.0 up to around 9.0, or even more preferably 8.0 to 8.5 or most preferably around 8.0. The droplets can have a mass median aerodynamic diameter from approximately 8 μm to approximately 15 μm or from approximately 15 μm to approximately 500 μm. A therapeutic dose (e.g., 0.5 mg to 4.0 mg mass of salt) is administered in response to an indication. Such can employ an osmolitically active composition.

The invention discloses a zymolyte microcapsule and a preparation method thereof, and belongs to the technical field of microcapsules. According to the method, calcium chloride is added in the process of preparing the sodium alginate solution, so that the stability of the wall material is improved, the loss of polypeptide in the homogenizing process can be reduced, the retention rate of the polypeptide is increased, and the loss of active substances is reduced. Positively charged calcium ions (Ca < 2 + >) can be strongly attracted by negatively charged carboxyl (-COO <->) on a sodium alginate chain to form a water-insoluble three-dimensional network structure. A large number of primary amino groups exist on a molecular chain of chitosan, a large number of carboxyl groups exist on a molecular chain of sodium alginate, and the primary amino groups and the carboxyl groups can form a polyelectrolyte membrane through positive and negative charge attraction, so that efficient embedding and intestinal targeted release of zymolyte are realized, and the stability and bioavailability of peptide are remarkably improved; and a technical basis is provided for developing functional foods based on the meat hydrolysate.

The invention belongs to the technical field of medicinal preparations, and particularly relates to a method for producing medicinal calcium carbonate with low content of chlorine, barium, magnesium and iron ions, which comprises the following steps: adding purified water into a general zone reaction kettle 1, adding calcium oxide while stirring, and reacting to obtain calcium hydroxide; dropwise adding concentrated hydrochloric acid into a system of the reaction kettle 1 under the condition of controlling the temperature, and after dropwise adding, carrying out heat preservation reaction until the end to obtain a calcium chloride solution; adding purified water into a general area reaction kettle 2, then adding ammonium carbonate, and stirring until the solution is clear to obtain an ammonium carbonate solution; filtering the ammonium carbonate solution in the reaction kettle 2 through a millipore filter membrane to enter a reaction kettle 3 in a clean area, filtering the calcium chloride solution in the reaction kettle 1 through the millipore filter membrane, dropwise adding the calcium chloride solution into the reaction kettle 3, and centrifuging to obtain a calcium carbonate wet product after the heat preservation reaction is finished; adding purified water into the calcium carbonate wet product, pulping, centrifuging and drying to obtain the medicinal calcium carbonate. On the basis of a double decomposition method, the method has the advantages of simplicity in operation, low cost, capability of realizing mass production and the like.

The invention discloses a preparation method of a high-absorptivity calcium supplement of vitamin D3 (VD3) and casein phosphopeptide chelated calcium (CPP-Ca), which comprises the following steps: firstly, dissolving casein phosphopeptide (CPP) in ultrapure water, adding calcium chloride, adjusting the pH value, stirring and reacting at a certain temperature to generate CPP-Ca, then precipitating by using ethanol, washing for multiple times to remove free calcium ions, and drying to obtain the high-absorptivity calcium supplement of vitamin D3 (VD3) and casein phosphopeptide chelated calcium (CPP-Ca). Centrifuging, collecting the precipitate, and freeze-drying to obtain purified CPP-Ca; the preparation method comprises the following steps: preparing CPP-Ca into a solution, adjusting the pH value, dropwise adding VD3 dissolved in ethanol into the solution, stirring and mixing at room temperature under a certain concentration to finally form the VD3 and CPP-Ca compound, and the compound prepared by the method can significantly promote calcium absorption and effectively improve the stability of VD3 and CPP.

The invention provides a high-temperature-resistant high-density solid-free water-based completion fluid as well as a preparation method and application thereof. The water-based completion fluid is prepared from the following components in parts by weight: 29 to 42 parts of water, 22 to 38 parts of phosphate, 12 to 17 parts of potassium formate, 8 to 12 parts of zinc bromide, 3 to 7 parts of calcium chloride, 0.5 to 2 parts of a flow pattern regulator, 2 to 3 parts of a corrosion inhibitor and 1 to 2 parts of a filtrate reducer, the flow pattern conditioning agent comprises a Dristemp and / or a Driscal D, and the flow pattern conditioning agent comprises a Dristemp and a Driscal D; the filtrate reducer is polyanionic cellulose; and the density of the water-based completion fluid is 1.6-2.2 g / cm < 3 >. The high-temperature-resistant high-density solid-free water-based completion fluid disclosed by the invention realizes good high-temperature resistance, and still has good viscosity, fluidity, temperature resistance and corrosion resistance after being subjected to hot rolling for 16 hours at the high temperature of 220 DEG C.

The invention provides a bone repair material and a preparation method and application thereof, the bone repair material is composed of BMP protein (bone morphogenetic protein), carboxymethyl chitosan and calcium chloride, the carboxymethyl chitosan is crosslinked through calcium chloride to form nanoparticles, and the BMP protein is effectively loaded through electrostatic interaction; the bone repair material has good biocompatibility, biosafety and biodegradability, not only can effectively wrap and protect BMP protein from rapid degradation by enzyme, enhance in-vivo stability of BMP protein and realize continuous and controllable release of BMP protein, but also is beneficial to reduction of oedema and ectopic bone risks due to low-dose medication, and has good application prospects. And finally, by promoting angiogenesis, promoting bone tissue development and relieving inflammation, formation and repair of bones are achieved.

The present invention provides a dehumidifier that ensures a sealing effect and prevents leakage of the calcium chloride liquid hygroscopic agent. [Solution] The dehumidifier includes a dehumidifying bag. The dehumidifying bag includes a breathable sheet section 2 and a non-breathable strip section 3 on the breathable side, and a non-breathable sheet section 1 on the non-breathable side. A double-sided sealing section 6 is provided in the center of the dehumidifying bag, which partitions the internal space surrounded by the non-breathable sheet section and the breathable sheet section. This double-sided sealing section divides the internal space into a fragrance material storage section 4 and a moisture-absorbing material storage section 5. A non-breathable strip section is provided at the opening of the moisture-absorbing material storage section. By providing the double-sided sealing section, the internal space of the dehumidifying bag is partitioned, and the fragrance material and moisture-absorbing material can be filled separately, thereby preventing mutual interference. In addition, by providing the non-breathable strip section, heat welding of the same material is possible after filling with the moisture-absorbing material, ensuring a sealing effect and preventing leakage of calcium chloride liquid.

The invention discloses human body simulation fasting gastric juice and a preparation method thereof, and belongs to the technical field of in-vitro dissolution experiments of pharmaceutical preparations. The invention aims to solve the problems that in the prior art, simulated gastric juice has significant differences with real empty gastric juice of a human body in the aspects of surface tension, osmotic pressure and buffer capacity, so that an in-vitro evaluation result of a dissolution behavior of a pharmaceutical preparation is inaccurate, and scientificity and reliability of an in-vitro dissolution experiment of a drug are influenced. The human body simulated fasting gastric juice comprises the following components: 2 to 30 mg / mL of bovine serum albumin, 0 to 7.517 E-05 mol / L of glycocholic acid or glycocholate, 0 to 7.421 E-05 mol / L of glycochenodeoxycholic acid or glycochenodeoxycholate, 0 to 8.369 E-04 mol / L of taurocholic acid or taurocholate, 0 to 9.005 E-04 mol / L of taurochenodeoxycholic acid or taurochenodeoxycholate, 0.025 to 0.138 g / L of calcium chloride, 0.478 to 1.12 g / L of potassium chloride, 0.015 to 0.063 g / L of magnesium chloride, 2.05 to 5.26 g / L of sodium chloride, 0.037 to 0.411 g / L of sodium dihydrogen phosphate and a pH regulator. The method can be used for evaluating the dissolution behavior of the pharmaceutical preparation in vitro, and is suitable for the fields of drug development, quality control and the like.

The present invention discloses an in-situ cross-linked self-degradable high-strength gel temporary plugging agent and a preparation method thereof, which belongs to the field of oil and gas field development technology. The gel temporary plugging agent is composed of the following substances in parts by weight: 0.33~2.33 parts of polyvinyl alcohol, 0.67~4.67 parts of corn amylopectin, 2.8~7.0 parts of acrylamide, 1.2~3.0 parts of N-vinyl pyrrolidone, 0.05~1.05 parts of a cross-linking agent, 0.001~0.06 parts of an initiator, 0.3~2.1 parts of glycerol, 0.02~0.14 parts of calcium chloride, and the remainder being water, and the sum of the weight parts of the above substances is 100 parts. Its preparation method is simple to operate, the raw materials are cheap and easy to obtain, the preparation process is controllable, and it shows a huge prospect for industrial promotion. The gel temporary plugging agent is used for a reservoir temporary plugging and diversion process, and can self-degrade under constant temperature conditions in the formation, which is of great significance for achieving efficient development of oil fields and improving oil and gas recovery.