56results about How to "Inhibit tumor metastasis" patented technology

Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating a subject at risk of developing benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating or preventing recurrence of a tumor using an anti-VEGF-specific antagonist as well as use of VEGF-specific antagonists in neoadjuvant and adjuvant cancer therapy.

The invention relates to preparation and application of a novel targeting peptide for specifically inhibiting tumor cell metastasis. The preparation method disclosed by the invention is technically characterized in that a polypeptide TMTP1-GG-D(KLAKLAK)2 which can simultaneously identify high metastasis potential tumor cells and inhibit tumor cell growth and metastasis is prepared, and antimicrobial peptides can be specifically transported into malignant tumor tissues and local metastasis through the polypeptide, so that the high metastasis potential tumor cells can be selectively killed, an obvious toxic or side effect is avoided, the tumor growth and metastasis are effectively inhibited, the polypeptide is expected to become a novel antitumor medicine, and the key defects in the conventional tumor molecule targeted therapy technology and practice can be overcome. The invention aims to provide the polypeptide which can simultaneously and specifically identify and restrict tumor cells with high metastasis potential tendency, so that the problems of large side effects, low specificity and the like existing in existing targeting medicines are solved, highly-efficient and specific tumor inhibiting and killing effects are expected to be achieved in clinical treatment, and the treatment aim of greatly killing the tumor cells in a targeted mode can be furthest achieved due to the novel polypeptide. In addition, the invention also can provide a novel design mode for subsequent other molecular therapy.

The invention discloses an acyl-tetrahydro-beta-carboline micro-molecular organic compound shown as a structural formula (I) or a hydrate thereof or pharmaceutically acceptable salts, application of a compound containing the acyl-tetrahydro-beta-carboline micro-molecular organic compound provided by the invention or a medical composition thereof to the preparation of medicaments for treating various diseases such as cancer, tumor metastasis and the like, and a preparation method of the acyl-tetrahydro-beta-carboline micro-molecular organic compound provided by the invention and derivatives thereof.

The invention discloses a green additive for increasing the lean meat rate and flavor of pork. The green additive is prepared from, by mass, 95-98% of natural plant compound and 2-5% of microorganism complex microbial inoculants. The natural plant compounds are prepared from, by mass, 45-55% of pine needle meal, 15-20% of paper mulberry leaf powder, 10-15% of perilla leaf powder, 5-10% of mulberry leaf powder, 5-10% of Chinese arborvitae twig powder and 5-10% of tea leaf powder. The microorganism complex microbial inoculants are obtained by evenly mixing streptococcus faecium ferment, lactobacillus plantarum ferment and bifidobacterium bifidum ferment and carrying out low-temperature freezing and drying. By the adoption of the green additive, the backfat thickness of pork can be decreased, the lean meat rate can be increased, the fat percentage can be decreased, the muscle unsaturated fattyacid content and flavor amino acid content can be significantly improved, the purposes of improving the meat quality and improving flavor are achieved, and economic benefits are considerable.

The present invention provide a beta-1,3/1,6-glucan, a preparation method therefor, and application thereof in preparing immune enhancement and anti-tumor medicine and functional food. The preparation method comprises: drying and milling antarctic brown algae; after degreasing, water extracting, calcium chloride precipitating and anion exchanging resin purification, obtaining glucan with a beta-1,3-glucose main chain and a beta-1,6-glucose branched chain, wherein a molecular weight thereof is between 5-50 kDa. The beta-glucan prepared by the present invention has an immune enhancement activity, which is indicated by swallow of neutral red by in vitro macrophages and an NO release promoting experiment, and has a tumor growth inhibiting effect and a tumor metastasis inhibiting effect which are indicated by an in vivo animal experiment. According to the present invention, beta-1,3/1,6-glucan is prepared by using the antarctic brown algae; is characterized in richness and readily availability of raw material sources, simple preparation process, high product purity, strong bioactivity and easiness for industrialization; and has a prospect of being developed into immune enhancement and anti-tumor medicine.

The invention discloses a construction scheme of artificially transforming human type 5 adenovirus (Ad5), and a specific application of a novel oncolytic adenovirus construct obtained by the scheme in tumor treatment, and belongs to the technical field of medical genetic engineering. A recombinant adenovirus construct obtained by PCR amplification site-directed deletion, enzyme digestion, ligation, cloning, homologous recombination, transfection, adenovirus monoclonal purification, etc., its technical characteristics are: Ad5 genome E1A conserved sequence 2 27 bases were deleted in the (CR2) region; 29477-29714nt of the ADP gene in the E3 region was deleted; and the full-length coding sequence (1131bp) of the HSV-TK gene was inserted in the deleted region. This construct is a new type of oncolytic adenoviral vector with higher tumor selective replication ability, which utilizes the suicide gene function of HSV-TK and the double killing effect of oncolytic virus to dissolve tumor cells, and has great potential in the biological treatment of tumors. Unique practical value.

An application of the polyose extracted from enqlish yew in preparing the medicines for improving immunity and the tolerance of body, preventing tumor, and treating lung cancer, stomach cancer, colon cancer, breast cancer and prostatic cancer is disclosed.

The invention relates to the field of medicinal chemistry and pharmacotherapeutics, particularly discloses an aryl formamide compound and a preparation method thereof, and also relates to applicationof the compound in preparing drugs for preventing or treating diseases caused by upregulation of hypoxia-inducible factors, application of the compound in preparing drugs for preventing or treating tumors or retinal vascular diseases and a pharmaceutical composition containing the compound.

The invention discloses a proposal for constructing novel oncocytic adenovirus of selectively closed tumor STAT3 obtained by manual reconstruction of human 5 type adenovirus (Ad5), and particular application of a recombined adenovirus constructor in tumor treatment, and belongs to the technical field of medical genetic engineering. By techniques of PCR enlarging fixed point deletion, enzyme cutting, connection, cloning, homologous recombination, transfection, single cloning purification of adenovirus and the like, the recombination adenovirus constructor is obtained. The technical characteristics comprise that 27 basic groups are deleted in an E1A conservative sequence 2(CR2) zone of Ad5 genome; 29477 to 29714nt in an E3 zone of ADP gene are deleted; and partial STAT cDNA segments are oppositely inserted in the deletion zones. The constructor is a novel oncocytic adenovirus vector with higher tumor selective copy capability. The constructor has unique practical values in biological treatment of tumor, and also provides a reasonable gene target point specificity treatment mode for the genetic treatment of tumor.

The present invention relates to the use of probucol or derivatives thereof for preparing drugs for inhibiting tumour metastasis, preferably breast cancer metastasis, and more preferably lung metastasis of breast cancer. The present invention also relates to the use of a pharmaceutical composition of probucol for preparing drugs for inhibiting tumour metastasis, preferably breast cancer metastasis, and more preferably lung metastasis of breast cancer, wherein the pharmaceutical composition of probucol comprises a therapeutically effective amount of one or more compounds selected from probucol or derivatives thereof, and pharmaceutical excipients.

This invention relates to establishment of artificially reformed human adenovirus 5 and use in treatment of cancers by reorganized configuration of adenovirus. It is obtained by extension of fixed-point deficiency, homologous reorganization, transfection, and monoclone purification of adenovirus. Its novelty includes deletion of 9 alkali groups in encoding sequence of ADV 5 gene set E1A conservative sequence 2, deletion of 28532-29360nt of ADV 5 E3 with reversed inserting some of PLK1 cDNA segments. The reorganized configuration of adenovirus can selectively regenerate in tumors, with specific expression of reversed PLK1 cDNA segments to kill tumor cells but normal cells. The configuration is unique effectiveness in diagnosis and treatment of tumors. It provides an ideal therapy of gene target specifility.

This invention relates to establishment of artificially reformed human adenovirus 5 and use in treatment of cancers by reorganized configuration of adenovirus. It is obtained by extension of fixed-point deficiency, homologous reorganization, transfection, and monoclone purification of adenovirus. Its novelty includes deletion of 9 alkali groups in encoding sequence of ADV 5 gene set E1A conservative sequence 2, deletion of 28532 - 29360nt of ADV 5 E3 with reversed inserting some of CHK1 cDNA segments. The reorganized configuration of adenovirus can selectively regenerate in tumors, with specific expression of reversed CHK1 cDNA segments to kill tumor cells but normal cells. The configuration is unique effectiveness in diagnosis and treatment of tumors. It provides an ideal therapy of gene target specifility.

The invention relates to the technical field of cassia twig and poria cocos pills, and particularly discloses a cassia twig and poria cocos pill formula for inhibiting tumor metastasis and a preparation process. The formula of the cassia twig and poria cocos pill for inhibiting tumor metastasis comprises 70-100 parts of cassia twig powder, 85-105 parts of poria cocos powder, 18-25 parts of astragalus membranaceus powder, 22-28 parts of sculellaria barbata powder and 55-70 parts of refined honey. The preparation device comprises a machine base, a raw material mixing device, an extrusion pelleting device and a rolling dryer. According to the cassia twig and poria cocos pill disclosed by the invention, the cassia twig powder and the poria cocos powder are taken as main components, a proper amount of astragalus membranaceus powder and a proper amount of sculellaria barbata powder are added as auxiliary materials, and the prepared cassia twig and poria cocos pill has a certain effect of inhibiting tumor metastasis through the mutual compatibility effect of the main materials and the auxiliary materials; and meanwhile, the disclosed device can sequentially achieve the effects of quantitative feeding, material mixing, pelleting, drying and the like, the functions are diversified, and the whole device is compact in structure, small in occupied area and excellent in use effect in the aspect of preparation of the cassia twig and poria cocos pills.

The invention belongs to the technical field of biological medicine, and particularly relates to a small-molecule inhibitor for targeted inhibition of PITPNM3 and application of the small-molecule inhibitor. According to the invention, 11 small molecule inhibitors for targeted inhibition of PITPNM3, which have a biological effect of targeted inhibition of PITPNM3 mediated cell adhesion and a biological effect of targeted inhibition of CCL18-PITPNM3 mediated cell migration adhesion, are screened by virtue of computer-aided drug design and high-throughput drugs, and can inhibit various PITPNM3 activated and mediated tumor metastasis; the compound has the advantages of wide application range and high targeting property, such as breast cancer, hepatocellular carcinoma, pancreatic ductal carcinoma and lung cancer.

The invention provides a polyprotein tumor comprehensive therapeutic medicine, which comprises tumor metastasis inhibition proteins, tumor inhibition proteins and a pharmaceutically acceptable vector or excipient. The polyprotein tumor comprehensive therapeutic medicine has more obvious effect compared with a single-protein therapeutic medicine.

This invention relates to establishment of artificially reformed human adenovirus 5 and use in treatment of cancers by reorganized configuration of adenovirus. It is obtained by extension of fixed-point deficiency, homologous reorganization, transfection, and monoclone purification of adenovirus. Its novelty includes deletion of 24 alkali groups in encoding sequence of ADV 5 gene set E1A conservative sequence 2, deletion of 28532 - 29360nt of ADV 5 E3 with reversed inserting some of CHK1 cDNA segments. The reorganized configuration of adenovirus can selectively regenerate in tumors, with specific expression of reversed CHK1 cDNA segments to kill tumor cells but normal cells. The configuration is unique effectiveness in diagnosis and treatment of tumors. It provides an ideal therapy of gene target specificity.

The invention discloses a liver cancer diagnosis and treatment marker, namely, LINC02128. The invention discloses the LINC02128 which can be used as a biomarker for liver cancer diagnosis and can alsobe used as a new target for developing a medicine for treating liver cancer.

The invention discloses abelmoschus manihot buccal tablets and a preparation method thereof. The abelmoschus manihot buccal tablets are mainly prepared from the following components in parts by weight: 40 to 50 parts of abelmoschus manihot medicus essential oil, 10 to 20 parts of dianthus chinensis root or whole grass condensed fluid, 10 to 20 parts of borago officinalis leaf condensed liquid, 10 to 20 parts of perilla frutescens leaf condensed liquid, 10 to 20 parts of rosa roxburghii tratt fruit honey cream and 15 to 25 parts of pectin, wherein the rosa roxburghii tratt honey cream is obtained by mixing rosa roxburghii tratt fruits and honey and processing. The abelmoschus manihot buccal tablets disclosed by the invention have the effects of beautifying, nourishing, regulating the immunity of a human body, reducing myocardial oxygen consumption, increasing the bleeding amount of coronary artery and cerebral vessels and improving the circulatory function.

The invention discloses a neoplasm metastasis suppressing pharmaceutical composition prepared by DMGF and an application of the neoplasm metastasis suppressing pharmaceutical composition. The neoplasm metastasis suppressing pharmaceutical composition comprises an effective dose of DMGF in respect of treatment and an acceptable carrier in respect of medicine. The invention further discloses the application of the neoplasm metastasis suppressing pharmaceutical composition prepared by DMGF. Neoplasm metastasis can be suppressed effectively by the neoplasm metastasis suppressing pharmaceutical composition and the application thereof.

The invention discloses a preparation method of nanoparticles of calcium carbonate-polydopamine coated drug-loaded bacterial outer membrane vesicles, which comprises the following steps: (1) preparation of OMVs: carrying out continuous subculture on escherichia coli strains until the escherichia coli strains grow stably, then inducing activated escherichia coli in logarithmic phase by using an IPTG inducer to generate OMVs, and carrying out freeze drying on the OMVs to obtain the nanoparticles of the drug-loaded bacterial outer membrane vesicles; (2) preparing OMVs (Ti): forming the OMVs (Ti) from the OMVs separated in the step (1) and a fat-soluble TGF-beta inhibitor through a membrane fusion method under an ice-water bath ultrasonic condition; and (3) preparing CaCO3-PDA-OMVs (Ti): adding the OMVs (Ti), CaCl22H2O, Na2CO3 and dopamine into a Tris-HCl (0.25 mM)-HEPES (25mM) buffer solution, and preparing by a one-pot method. The drug-loaded nanoparticles prepared by the invention have the advantages of no toxicity, high-efficiency delivery of inhibitors, activation of autoimmunity and the like.

The express and adjust method for GRP in bio-medicine field comprises: modifying the GRP into secretory protein to load into the tumor cell cultured externally; then, the altumen stimulates the body anti-tumor immunity function to prepare tumor-vaccine and cure tumor; while injecting directly the albumen adenovirus to infect the tumor cell and express the albumen for tumor treatment with chemotherapy and radiotherapy.

The invention belongs to the technical field of pharmacochemistry and discloses a use of ursolic acid in preparing medicine capable of regulating and controlling tumour cell division cycle. Experiments indicate that the ursolic acid can change the division cycle of lung cancer cell, gastric cancer cell, liver cancer cell, breast cancer cell and leukemia cell, and obviously control the cell division of the lung cancer cell, gastric cancer cell, liver cancer cell, breast cancer cell and leukemia cell. The ursolic acid can be used for preparing medicine capable of restraining the cell division of the tumour cell.