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Application of probucol and derivative thereof in resisting tumor metastasis

A technology for probucol and tumor metastasis, applied in the field of anti-tumor metastasis of probucol and its derivatives

Inactive Publication Date: 2014-08-27
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the prevention and treatment of tumor metastasis is facing very severe challenges.

Method used

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  • Application of probucol and derivative thereof in resisting tumor metastasis
  • Application of probucol and derivative thereof in resisting tumor metastasis
  • Application of probucol and derivative thereof in resisting tumor metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 probucol solution

[0015] The probucol raw material (Hebei Wuyi Cihang Pharmaceutical Co., Ltd., purity 99.7%) was dispersed in water, buffer, or a solution containing 0.5% sodium carboxymethylcellulose or 0.1% hydroxypropylcellulose.

Embodiment 2

[0016] Embodiment 2 probucol derivative AGI-1067 solution

[0017] The probucol derivative AGI-1067 (Shanghai Haoyuan Chemical Technology Co., Ltd., purity 98.0%) was dispersed in water, buffer, or a solution containing 0.5% sodium carboxymethylcellulose or 0.1% hydroxypropylcellulose.

Embodiment 3

[0018] Embodiment 3 probucol granules

[0019] Probucol and starch, pregelatinized starch, microcrystalline cellulose, lactose, povidone, etc. are prepared into drug-containing granules by wet granulation, dry granulation or direct mixing.

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PUM

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Abstract

The present invention relates to the use of probucol or derivatives thereof for preparing drugs for inhibiting tumour metastasis, preferably breast cancer metastasis, and more preferably lung metastasis of breast cancer. The present invention also relates to the use of a pharmaceutical composition of probucol for preparing drugs for inhibiting tumour metastasis, preferably breast cancer metastasis, and more preferably lung metastasis of breast cancer, wherein the pharmaceutical composition of probucol comprises a therapeutically effective amount of one or more compounds selected from probucol or derivatives thereof, and pharmaceutical excipients.

Description

technical field [0001] The present invention relates to the new application of probucol and its derivatives, in particular to the preparation of probucol and its derivatives which have anti-tumor metastasis, reduce the incidence of malignant tumor metastasis, reduce the number of metastatic foci, and improve the survival rate of tumor-bearing animals. Uses in medicine. Background technique [0002] Tumor metastasis (Cancer metastasis) refers to the process that tumor cells dissociate from the primary tumor, infiltrate into surrounding tissues, invade into the circulatory system and then metastasize in vivo, and adhere and infiltrate with endothelial cells to form metastases. Tumor metastasis is one of the main reasons for tumor refractory and recurrence, and also a key factor leading to the death of tumor patients. Clinical diagnosis results show that more than 60% of newly diagnosed cancer patients have metastasized, and their 5-year survival rate is less than 20%. At pre...

Claims

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Application Information

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IPC IPC(8): A61K31/10A61K31/222A61P35/04A61P15/14
CPCA61K31/10A61K31/222A61K9/10A61K9/1075A61K9/141A61K9/16A61K9/20A61K9/48A61K9/51A61K31/215A61P15/14A61P35/04A61K2300/00
Inventor 李亚平张志文刘泽莹
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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