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Application of yew amylose in pharmacy

A technology of yew polysaccharides and drugs, which is applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulas, and can solve problems such as limited biological resources, poor water solubility, and toxic and side effects, so as to expand the application team, enhance tolerance, and avoid resources. wasteful effect

Inactive Publication Date: 2007-05-09
宁波泰康红豆杉生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Paclitaxel extracted from the yew plant has long been proven to have anti-tumor activity and has been widely used, but the application of paclitaxel as an anti-tumor drug is subject to the following limitations: First, the biological resources are limited, and 4000 yew trees need to be peeled off to obtain 1 kg of paclitaxel 10 tons of bark, the second is that its water solubility is poor, the third is that the body has obvious drug resistance after long-term use of paclitaxel, and the fourth is that the drug has toxic and side effects on the body

Method used

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  • Application of yew amylose in pharmacy
  • Application of yew amylose in pharmacy
  • Application of yew amylose in pharmacy

Examples

Experimental program
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Effect test

preparation example 1

[0132] Take 500g of dry branches and leaves of yew plant, crush them to below 40 mesh, sieve, soak in ethyl acetate solution overnight, dry in the air, pass through 0.9Nacl solution, 85% ethanol solution, 95 degree hot water, 1% ammonium oxalate solution, 5% NaoH solution, 20% NaoH solution, sequentially extracted to obtain crude polysaccharide extract, freeze-dried, deproteinized, then freeze-dried, purified by ultrafiltration chromatography to obtain primary pure polysaccharide, then vacuum-dried, purified by molecular chromatography to obtain high-purity polysaccharide 0.7037 g, dissolved in 61 g of distilled water, added with necessary carriers approved by the field of pharmaceuticals, routinely sterilized, and made into a yew polysaccharide oral liquid with a concentration of 1%.

preparation example 2

[0134] Take 500g of the dry branches and leaves of the yew plant, crush them to below 40 mesh, sieve, soak in ethyl acetate solution overnight, dry in the air, pass through 0.9Nacl solution, 85% ethanol solution-95 degree hot water, 1% ammonium oxalate solution, 5% NaoH solution, 20% NaoH solution, sequentially extracted to obtain crude polysaccharide extract, freeze-dried, deproteinized, then freeze-dried, purified by ultrafiltration chromatography to obtain primary pure polysaccharide, then vacuum-dried, purified by molecular chromatography to obtain high-purity polysaccharide 0.6853 g, dissolved in 11 g of distilled water, added with necessary carriers approved by the pharmaceutical field, routinely sterilized, and made into a 5% yew polysaccharide oral liquid.

preparation example 3

[0136] Take 500g of the dry branches and leaves of the yew plant, crush them to below 40 mesh, sieve, soak in ethyl acetate solution overnight, dry in the air, pass through 0.9Nacl solution, 85% ethanol solution-95 degree hot water, 1% ammonium oxalate solution, 5% NaoH solution, 20% NaoH solution, sequentially extracted to obtain crude polysaccharide extract, freeze-dried, deproteinized, then freeze-dried, purified by ultrafiltration chromatography to obtain primary pure polysaccharide, then vacuum-dried, purified by molecular chromatography to obtain high-purity polysaccharide 0.6626g, and then sub-packed into hard capsules each containing 1mg of necessary carrier starch approved by the field of medicine, 0.05mg of magnesium stearate, and 0.45mg of the active ingredient of yew polysaccharide.

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Abstract

An application of the polyose extracted from enqlish yew in preparing the medicines for improving immunity and the tolerance of body, preventing tumor, and treating lung cancer, stomach cancer, colon cancer, breast cancer and prostatic cancer is disclosed.

Description

technical field [0001] The invention relates to the application of plant polysaccharides in the field of pharmacy, in particular to the application of yew polysaccharides in pharmacy. Background technique [0002] The present inventor has disclosed yew polysaccharide extract and preparation method thereof in CN0129421.9, and its structural formula is: [0003] [0004] Hydrogen atom Chemical shift (peak intensity) Number of hydrogen atoms [0005] H1 4.73725(0.9411) 1 [0006] H2 3.03529(1.000) 1 [0007] H5 3.51608(1.2129) 1 [0008] H3, 4, 6, 6 3.66585-3.76325(3.7320) 4 [0009] HA 1.19985-1.29622(3.5409) 3 [0010] HB 4.14336-4.16975(1.2697) 1. [0011] Taxus polysaccharides are mainly heteropolysaccharides composed of D-glucose and a small amount of D-xylose, arabinose, galactose and glucuronic acid with β-1,3 glycosidic bonds. On its β-1,3 glucan main chain There are a small amount of β-1,6 glycosidic bond branched chain, the molecular weight is 160000-220000,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P37/02A61P35/00A61P35/04
Inventor 孔繁智朱婉萍
Owner 宁波泰康红豆杉生物工程有限公司
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