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MiRNA group for early diagnosis and/or prognosis monitor of pancreatic caner and application of miRNA

A technology for early diagnosis of pancreatic cancer, applied in the direction of DNA/RNA fragments, recombinant DNA technology, biochemical equipment and methods, etc., can solve the problems of low survival rate, failure of diagnosis and treatment management of pancreatic cancer patients, and reduce ineffective chemotherapy rate, early stop of low-efficiency chemotherapy, and the effect of preventing early metastasis

Pending Publication Date: 2020-05-19
AFFILIATED HOSPITAL OF JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Failure of current diagnosis and treatment management is one of the main reasons for the poor survival of pancreatic cancer patients, therefore, new diagnostic and prognostic biomarkers are needed for early diagnosis and targeted therapy

Method used

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  • MiRNA group for early diagnosis and/or prognosis monitor of pancreatic caner and application of miRNA
  • MiRNA group for early diagnosis and/or prognosis monitor of pancreatic caner and application of miRNA
  • MiRNA group for early diagnosis and/or prognosis monitor of pancreatic caner and application of miRNA

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Embodiment 1

[0043] figure 1 It schematically shows a system for early diagnosis and / or prognosis monitoring of pancreatic cancer according to an embodiment of the present invention, including a configuration module 100, a storage module 200, a quantitative detection module 300, an input module 400, and a risk analysis module 500 And output module 600.

[0044] The quantitative detection module 300 is used to detect the expression level of the risk miRNA of the subject. Among them, risk miRNAs include: miR-143, miR-218, miR-217, miR-216a, miR-205, miR-145, miR-195, miR-193a and miR-127. The quantitative detection module 300 may be specifically implemented as a product for detecting the expression level of risk miRNA, for example, it may be a reagent, kit, chip and / or instrument for detecting the expression level of risk miRNA in a sample by at least one of the following methods: Northern-Blotting Hybridization technology, reverse transcription PCR technology, reverse transcription-real-time ...

Embodiment 2

[0110] 22 cases of pancreatic cancer patients with blood and cancer tissues and corresponding adjacent tissues were taken from patients who underwent radical resection of pancreatic cancer at the General Surgery Department of Wuxi Third People's Hospital from July 2016 to July 2018. All of them had informed consent and signed written documents . There were 10 females and 12 males, aged 40-73 years old, with a median age of 55 years. The specimens were washed with DEPC water within half an hour from the body, and then a sharp blade was used to quickly cut 5 pieces of pancreatic cancer and adjacent tissues (more than 3cm from the cancerous tissue) each, and remove the blood vessels, nerves and connective blocks that may be attached. All cases did not undergo chemotherapy, radiotherapy or immunotherapy before operation, and the postoperative physical examination was jointly diagnosed by two pathologists, and the paraffin pathology was pancreatic cancer. Immediately after the tiss...

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Abstract

The invention discloses a miRNA group related to the pancreatic cancer. The miRNA group includes the following miRNA: miR-143, miR-218, miR-217, miR-216a, miR-205, miR-145, miR-195, miR-193a and miR-127. The miRNA group can be used as an early detection marker and prognosis biomarker for the pancreatic cancer, and is applied to early diagnosis and / or prognosis monitor of the pancreatic cancer, sothat early diagnosis of the pancreatic cancer is achieved, and the opportunity for early diagnosis and treatment of the pancreatic cancer is seized; and / or whether a pancreatic cancer patient has risks of early metastasis and drug resistance or not can be evaluated, so that a medication plan is adjusted in time, occurrence of early metastasis is prevented, and the survival time of patients is prolonged.

Description

Technical field [0001] The present invention relates to the field of biotechnology, in particular to a group of miRNA groups for early diagnosis and / or prognosis monitoring of pancreatic cancer and their applications. Background technique [0002] Pancreatic cancer is one of the most aggressive malignant tumors. It is a highly malignant malignant tumor of the digestive tract that is difficult to diagnose and treat. About 90% of them are ductal adenocarcinomas originating from the ductal epithelium. The incidence and mortality of pancreatic cancer have increased significantly in recent years, with 5-year survival rate <1%, is one of the worst prognostic malignancies. The main difficulty in the treatment of pancreatic cancer patients is that they lack effective early molecular markers and are prone to early metastasis. The early occurrence and development of pancreatic cancer cannot be diagnosed in time, and the best time for diagnosis and treatment is delayed, resulting in low ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/113C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 薛育政
Owner AFFILIATED HOSPITAL OF JIANGNAN UNIV
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