Application of gentiopicroside (Gen) in reversing multidrug resistance of hepatoma cell HepG2

A technology of gentiopicroside and multidrug resistance, applied in the application field of gentiopicroside in reversing multidrug resistance of liver cancer cell HepG2

Pending Publication Date: 2020-06-02
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The effect of gentiopicroside on multidrug-resista

Method used

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  • Application of gentiopicroside (Gen) in reversing multidrug resistance of hepatoma cell HepG2
  • Application of gentiopicroside (Gen) in reversing multidrug resistance of hepatoma cell HepG2
  • Application of gentiopicroside (Gen) in reversing multidrug resistance of hepatoma cell HepG2

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Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0021] The present invention not only reveals the inhibitory effect of gentiopicroside on multidrug-resistant liver cancer cells, but also discovers the apoptosis-promoting effect of the combination of gentiopicroside and fluorouracil and other chemotherapeutic drugs on liver cancer cells. To provide a practical basis for drug and solve the plight of tumor multi-drug resistance.

[0022] (1) Inhibitory effect of gentiopicroside on multidrug-resistant liver cancer cells

[0023] The present invention selects the American Type Culture Collection (ATCC) human liver cancer reference cell line HepG2 (purchased from the Shanghai Cell Engineering Center of the Chinese Academy of Sciences) as the starting cell line, and simulates t...

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Abstract

The invention discloses application of gentiopicroside (Gen) in reversing multidrug resistance of hepatoma cell HepG2. The Gen can not only inhibit growth of the multidrug resistant hepatoma cell lineHepG2R, but also be used as a chemosensitizer to enhance sensitivity of the HepG2R to chemotherapy drugs such as fluorouracil and doxorubicin, promote multidrug resistant hepatoma cell apoptosis, andcan be applied to preparation of a tumor inhibitor according to the characteristic of reversing the multidrug resistance of cells.

Description

technical field [0001] The present invention relates to the application of gentiopicroside, an active ingredient of traditional Chinese medicine, as a tumor inhibitor and chemotherapy sensitizer, in particular to the application of gentiopicroside in enhancing the sensitivity of multidrug-resistant liver cancer cells to fluorouracil and other chemotherapy drugs, and inducing cell apoptosis. effect. Background technique [0002] Liver cancer is a malignant tumor that occurs in the liver, including primary liver cancer and metastatic liver cancer, and is one of the main tumors that seriously threaten people's health and life. At present, hepatic arterial interventional chemoembolization is usually used for patients with unresectable middle-advanced liver cancer, that is, hepatic artery is inserted through the artery, and embolic agents and / or chemotherapy drugs are injected to control tumor growth. The commonly used chemotherapeutic drugs mainly include: fluorouracil (5-Fu), ...

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Application Information

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IPC IPC(8): A61K31/7048A61K31/513A61K31/704A61K33/243A61P35/00
CPCA61K31/7048A61K31/513A61K31/704A61K33/243A61P35/00A61K2300/00
Inventor 王婷乔晓宾张敏任娟贺钰婷
Owner SHAANXI UNIV OF SCI & TECH
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