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A sprayable anti-adhesion material and anti-adhesion tissue sealant and preparation method thereof

An anti-adhesion and sealant technology, applied in the field of medical materials, can solve the problems of poor adhesion and fast degradation of anti-adhesion materials, and achieve the effects of high adhesion, appropriate retention time in the body, and enhanced barrier properties.

Active Publication Date: 2022-03-25
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the existing anti-adhesion materials, such as too fast degradation speed and poor sticking performance, and provide a sprayable anti-adhesion material

Method used

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  • A sprayable anti-adhesion material and anti-adhesion tissue sealant and preparation method thereof
  • A sprayable anti-adhesion material and anti-adhesion tissue sealant and preparation method thereof
  • A sprayable anti-adhesion material and anti-adhesion tissue sealant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] An anti-adhesion material, the anti-adhesion material includes an effective component A and an effective component B, wherein the effective component A is a slightly cross-linked hyaluronic acid-gelatin copolymer aqueous solution, and the effective component B is a saturated solution of racemic polylactic acid , wherein the micro-crosslinked hyaluronic acid-gelatin copolymer is formed by micro-crosslinking hyaluronic acid and gelatin under the action of a crosslinking agent,

[0066] Wherein the preparation method of micro-crosslinked hyaluronic acid-gelatin copolymer is as follows:

[0067] S1. Measure hyaluronic acid (HA, 1.25g, dissolved in 62.5mL distilled water, pH value is 3.5), gelatin (Gel, 1.25g, dissolved in 12.5mL distilled water) and cross-linking agent carbodiimide ( EDC, 0.5g, dissolved in 5mL distilled water), the ratio is (M HA +M Gel ):M EDC =5:1, M HA :M Gel = 1:1;

[0068] S2. Put 62.5mL of HA aqueous solution in a 500mL Erlenmeyer flask, place ...

Embodiment 2

[0077] An anti-adhesion material, the anti-adhesion material includes an effective component A and an effective component B, wherein the effective component A is a micro-crosslinked hyaluronic acid-gelatin copolymer, and the effective component B is a saturated solution of racemic polylactic acid, The micro-crosslinked hyaluronic acid-gelatin copolymer is formed by micro-crosslinking hyaluronic acid and gelatin under the action of a crosslinking agent.

[0078] Wherein the preparation method of micro-crosslinked hyaluronic acid-gelatin copolymer is as follows:

[0079] S1. Measure hyaluronic acid (HA, 1.25g, dissolved in 62.5mL distilled water, pH value is 3.5), gelatin (Gel, 0.42g, dissolved in 4.2mL distilled water) and cross-linking agent carbodiimide ( EDC, 0.167g, dissolved in 3.3mL distilled water), the ratio is (M HA+M Gel ):M EDC =10:1, M HA :M Gel = 3:1;

[0080] S2. Place 62.5mL of HA aqueous solution in a 500mL Erlenmeyer flask, place the Erlenmeyer flask in a...

Embodiment 3

[0089] An anti-adhesion material, the anti-adhesion material includes an effective component A and an effective component B, wherein the effective component A is a micro-crosslinked hyaluronic acid-gelatin copolymer, and the effective component B is a saturated solution of racemic polylactic acid, The micro-crosslinked hyaluronic acid-gelatin copolymer is formed by micro-crosslinking hyaluronic acid and gelatin under the action of a crosslinking agent.

[0090] Wherein the preparation method of micro-crosslinked hyaluronic acid-gelatin copolymer is as follows:

[0091] S1. Measure hyaluronic acid (HA, 2.24g, dissolved in 112.0mL distilled water, pH value is 3.5), gelatin (Gel, 0.56g, dissolved in 4.7mL distilled water) and cross-linking agent carbodiimide ( EDC, 0.2g, dissolved in 4.0mL distilled water), the ratio is (M HA +M Gel ):M EDC =14:1, M HA :M Gel =4:1;

[0092] S2. 112.0mL of HA aqueous solution was placed in a 500mL Erlenmeyer flask, and the Erlenmeyer flask w...

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Abstract

The invention discloses an anti-adhesion material and an anti-adhesion tissue sealant which can be sprayed and a preparation method thereof. The anti-adhesion material includes effective component A and effective component B, wherein the effective component A is an aqueous solution of a degradable hydrophilic natural polymer copolymer, and the effective component B is a good solvent for a degradable hydrophobic synthetic polymer. Saturated solution, the solvent of effective component A and the solvent of effective component B solution are miscible. The hyaluronic acid component of the present invention can promote wound healing, the micro-crosslinking copolymerization of gelatin and hyaluronic acid materials can enhance the adhesion behavior and tissue affinity of the material, and the polymer film structure of polylactic acid can strengthen damaged organs The barrier between organs and tissues can reduce friction and adhesion between organs and tissues. The double-sided micro-crosslinked hyaluronic acid-gelatin copolymer network has a lubricating effect between tissues, and can reduce and inhibit bleeding and oozing at the same time. The overall structure has absorbable properties, high adhesion and proper in vivo retention time.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a sprayable anti-adhesion material and anti-adhesion tissue sealant and a preparation method thereof. Background technique [0002] In clinical operations, postoperative tissue adhesion is a common but underestimated thorny problem. In pelvic and abdominal surgery, the incidence of postoperative adhesion is as high as 90%, and 35% of the patients need to be reapplied due to adhesion within 10 years after operation. 2.1 operations, 22% of patients required reoperation within the first year of the first operation. In my country, anti-adhesion has a broad market prospect, and people in the industry joked that anti-adhesion products are "antibiotics" in the medical consumables market. In order to reduce and prevent the occurrence of adhesion, there are currently many anti-adhesion measures with different mechanisms. The main components of anti-adhesion products include med...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/04A61L24/00
CPCA61L24/104A61L24/08A61L24/046A61L24/001A61L24/0042A61L2400/10A61L2400/04C08L5/08
Inventor 马骋邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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