Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing azoxystrobin

A technology of azoxystrobin and methyl methoxyacrylate, which is applied in the field of preparation of fungicides, can solve the problems that DABCO is not easy to be recycled and reused, and achieve the effect of environmental friendliness

Active Publication Date: 2020-06-05
SINON CORP
View PDF11 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, it can be learned from the above-mentioned prior art that although DABCO was mostly used as a reaction catalyst in the past, because DABCO has the problem that it is not easy to recycle and reuse, it is not a suitable catalyst selection.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing azoxystrobin
  • Method for preparing azoxystrobin
  • Method for preparing azoxystrobin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Step (a) is (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methyl methoxyacrylate, 2-cyanophenol, potassium carbonate and 10 -80mol% of 1-methylpyrrolidine as a catalyst is mixed in an aprotic solvent to form an alkaline mixture, and the alkaline mixture is reacted at a temperature of 60-120° C. for 2-5 hours, so that the alkaline mixture is relatively good response environment.

[0021] In step (a), based on the consideration of effect and cost, the preferred condition of the catalyst 1-methylpyrrolidine is 10-80mol%; the preferred aprotic solvent is toluene, N,N-dimethyl Formamide or methyl isobutyl ketone; the alkaline mixture is first subjected to azeotropic water removal at 50-60°C and 100-120 torr, thereby effectively increasing the yield of the azoxystrobin, but azeotropic water removal Not a requirement.

[0022] The step (b) is to carry out the first vacuum distillation on the alkaline mixture after the reaction of the step (a) at 70-80° C. and 80-120 torr, so...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A method for preparing azoxystrobin comprises the following steps: (a) mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate, 2-cyanophenol, potassium carbonate, and 10-80 mol% of 1-methylpyrrolidine as a catalyst in an aprotic solvent to form a basic mixture, and reacting the basic mixture for 2-5 hrs at a temperature of 60-120 DEG C; and (b) subjecting the basic mixture after reaction in Step (a) to a first distillation under a reduced pressure of 80-120 torr at 70-80 DEG C, to obtain azoxystrobin.

Description

technical field [0001] The present invention relates to the preparation method of bactericide, especially relates to the preparation method of azoxystrobin. Background technique [0002] Compound (E)-2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxymethyl acrylate is a widely used agricultural The scientific name is Azoxystrobin, and the Chinese name is Yatropin or Azoxystrobin. [0003] See PCT Publication No. WO9208703, which discloses that derivatives of phenoxypyrimidine have bactericidal efficacy. [0004] In addition, U.S. Patent No. US5395837 discloses a synthetic method for 4,6-bis(aryloxy)pyrimidine derivatives, using potassium carbonate as a base, N,N-dimethylformamide (DMF) as a solvent, and chlorination Under the condition of cuprous (CuCl) as catalyst, react at 95~100 ℃, the yield is 64%, and the reaction formula is as follows: [0005] [0006] Also, Bayer company in PCT Publication No. WO 0172719 further discloses that phenoxy derivatives and c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/52
CPCC07D239/52A01N43/54B01D3/10B01D3/36
Inventor 陈建兴谢明芳林志达柳建宇
Owner SINON CORP