Preparation method of dasatinib hydrate

Abstract

The invention provides a preparation method ofdasatinib hydrate. The dasatinib hydrate is prepared by reacting a compound shown asstructural formula I in a compound a and a compound b. According to the technical scheme provided by the invention, the high-quality dasatinib hydrate can be obtained, tedious separation and purification steps are avoided, the operation is simple, the waste of raw materials is also avoided, the production cost is reduced, and the method is more suitable for industrial production.

Description

technical field [0001] The invention relates to the field of drug synthesis, in particular to a preparation method of dasatinib anhydrate. Background technique [0002] The chemical name of Dasatinib monohydrate is N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2 -Methyl-4-pyrimidinyl] amino]-5-thiazole carboxamide (monohydrate), its structural formula is as follows: [0003] [0004] Dasatinib is a potent multi-target inhibitor of tyrosine kinase, and it is another drug for imatinib-resistant and intolerant CML in the chronic phase after nilotinib . Compared with imatinib and nilotinib, which target the single target of Bcr-Abl fusion protein, dasatinib is a multi-target drug that has effects on five key oncogenic tyrosine protein kinases. The product was first developed by Bristol-Myers Squibb. It was approved for marketing in the US in June 2006 and launched in the EU in November. The existing synthetic route of Dasatinib is as follows. [00...

AI Technical Summary

Problems solved by technology

[0011] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of preparation method of dasatinib anhydrate, for solving the harsh reaction conditions and high cost of preparing dasatinib existing in the prior art , not easy to purify, not suitable for large-scale industrial production

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