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hras protein autoantibody and its application

An autoantibody and protein technology, applied in the field of biomedicine, can solve the problems of limited clinical application value and low sensitivity, and achieve good application prospects, simple operation and low cost

Active Publication Date: 2020-12-01
北京三品医疗科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although anti-HRAS autoantibodies have been studied, their sensitivity is low and their clinical application value is limited.

Method used

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  • hras protein autoantibody and its application
  • hras protein autoantibody and its application
  • hras protein autoantibody and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 Application of HRAS Autoantibodies in Serum in Detection of Lung Cancer

[0063] 1. Clinical samples

[0064] 202 lung cancer patients and 107 healthy controls were selected. The basic information is shown in Table 1:

[0065] Table 1: Basic information table of lung cancer patients

[0066]

[0067]

[0068] 2. Basic principles

[0069] HRAS protein is immobilized on the enzyme-labeled well plate. After incubation with serum, HRAS autoantibodies (mainly including IgG, IgA antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then add anti-human IgA horseradish peroxidase-labeled secondary antibody or anti-human IgG horseradish peroxidase-labeled secondary antibody for incubation, wash off the unbound secondary antibody, add horseradish peroxidase substrate, and wait for the substrate After color development, the intensity of the signal is positively corr...

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Abstract

The invention discloses an HRAS protein autoantibody and application thereof, including application of the HRAS protein autoantibody in preparation of cancer detection products and application of theHRAS protein autoantibody in cancer detection. Effective detection and auxiliary diagnosis of cancer can be realized, and a lung cancer patient and a healthy person can be accurately identified; serumcan be used as a detection sample, and the HRAS protein autoantibody is simple to operate, low in cost, high in accuracy and noninvasive. The HRAS protein autoantibody has a good application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to HRAS protein autoantibody and its application in preparing cancer detection products and cancer detection. Background technique [0002] According to data from the World Health Organization, in 2018, the number of new cancer cases worldwide reached 18.1 million, 9.6 million people died of cancer, and 2.09 million new cases of lung cancer occurred worldwide, ranking first among all cancer types. According to the statistics of the National Cancer Center in 2017, the morbidity and mortality of lung cancer rank first among malignant tumors, with an incidence rate of 20.27% among males and 14.94% among females. Breast cancer (17.07%); the mortality rate occupies the first place in both men and women, 23.89% and 17.70% respectively. It is predicted that from 2015 to 2030, the mortality rate of lung cancer in China may increase by about 40%. [0003] Lung cancer can be divided i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/574G01N33/573
CPCG01N33/573G01N33/57407G01N33/57423G01N33/6854G01N2333/914
Inventor 王红叶李永哲韩晓红姚林
Owner 北京三品医疗科技有限公司