Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Green synthesis method of sulfadiazine

A technology of sulfadiazine and green synthesis, applied in the direction of organic chemistry, can solve the problems of high cost of environmental protection treatment, high difficulty in the treatment of high-phosphorus organic waste liquid, and secondary environmental pollution

Pending Publication Date: 2020-06-12
湖南吴赣药业有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventors have developed an improved process for producing Sulfurazepan (also called 1) that overcomes problems associated with previous methods such as high levels of nitrogen compounds or excessive use of expensive reagents like pH neutralizing agents used during chemical reaction steps. This new technology reduces pollution caused by traditional processes while still yielding good quality materials at lower cost than current alternatives.

Problems solved by technology

The technical problem addressed by this patented technology relates to how to produce pure sulfurazepainanone efficiently without generating excessive amounts of harmful chemical wastes that are hard for disposal or causing damage from overuse.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Green synthesis method of sulfadiazine
  • Green synthesis method of sulfadiazine

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] The green synthetic method of sulfadiazine of the present invention, as figure 1 and figure 2 As shown, it includes the following steps: (a) adding 3-alkoxyacrolein (3-alkoxyacrolein is 3-methoxyacrolein or 3-ethoxypropenal) to the mixture of organic alcohol solvent and sulfamidine Acrolein), after mixing, heat up and reflux to carry out the ring-forming reaction; the chemical structure of the organic alcohol is R—OH, where R is a C1~C4 alkyl group; the temperature of the ring-forming reaction is 50°C~ 140°C; the molar ratio of the sulfamidine to the 3-alkoxyacrolein is 1:1~1.2; (b) after the completion of the cyclization reaction, cool down the mixed material for solid-liquid separation, and obtain The solid is crude sulfadiazine, and the obtained liquid is recycled; (c) adding the crude sulfadiazine to the liquid caustic soda, raising the temperature to carry out a salt-forming reaction, then stirring and decolorizing, and filtering to obtain the filtrate; (d) dripp...

Embodiment 1

[0023] The present embodiment provides a kind of green synthetic method of sulfadiazine, and it comprises the following steps:

[0024] (a) Under normal pressure, add 100g of methanol into the reactor, then add 21.42g of sulfamidine, stir evenly, add 10.33g of 3-methoxyacrolein, stir evenly, raise the temperature to 100°C for reflux and continue to keep warm for 4 hours;

[0025] (b) After the reaction, lower the temperature to 40°C, separate the solid to obtain the crude sulfadiazine, and the liquid is a mixture of solvent and unreacted raw materials (for recycling);

[0026] (c) Add crude sulfadiazine (in step (b)) to 100g of liquid caustic soda, raise the temperature to dissolve the sodium salt of sulfadiazine, and raise the temperature to 70°C to form a salt; add activated carbon, stir for 30 minutes to decolorize, filter to remove the activated carbon to obtain the filtrate ;

[0027] (d) Add 30% hydrochloric acid dropwise to the filtrate until the pH is 5.1~5.4, and car...

Embodiment 2

[0029] This example provides a green synthesis method of sulfadiazine, which is basically the same as that in Example 1, except that: in step (a), 12 g of 3-ethoxyacrolein is added, and the organic alcohol solvent is ethanol; finally The yield of the high-purity sulfadiazine product is 85%, and the purity is 99.2%; after the reaction solution is applied mechanically, the yield is 91%, and the purity is 98.6%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a green synthesis method of sulfadiazine. The green synthesis method comprises the following steps: (a) adding 3-alkoxy acrolein into a mixture of an organic alcohol solvent and sulfaguanidine, mixing, heating, and refluxing to perform cyclization reaction; (b) after the cyclization reaction is finished, cooling the mixed material to carry out solid-liquid separation to obtain a solid which is a sulfadiazine crude product, and recycling the obtained liquid; (c) adding the sulfadiazine crude product into liquid caustic soda, heating to carry out salifying reaction, thenstirring to decolorize, and filtering to obtain filtrate; and (d) dropwise adding a hydrochloric acid solution into the filtrate, carrying out acidification crystallization, separating crystals, and drying. Phosphorus-containing organic waste liquid is not generated, and the solid waste generation amount is low.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner 湖南吴赣药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com