Rhus chinensis total phenolic acid micropellets and preparation method thereof

A technology of total phenolic acid pellets and chrysanthemum, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Difficult pilling, strong wetness and other problems, to achieve the effect of large-scale industrial production, good pilling performance and good reproducibility

Active Publication Date: 2020-06-19
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is very difficult to prepare micropellets due to the strong hygroscopicity and high viscosity of the total phenolic acid of S. chinensis, which is also common knowledge in the art
Therefore, the prior art has not successfully prepared the total phenolic acid pellets

Method used

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  • Rhus chinensis total phenolic acid micropellets and preparation method thereof
  • Rhus chinensis total phenolic acid micropellets and preparation method thereof
  • Rhus chinensis total phenolic acid micropellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1, the preparation of total phenolic acid of the present invention

[0044] Take an appropriate amount of the coarse powder of the medicinal material, add 20 times the amount of 70% ethanol (that is, add 20 mL of 70% ethanol to 1 g of the coarse powder of the medicinal material), soak for 30 minutes, reflux extraction for 90 minutes, extract twice, filter, and combine the filtrates to obtain the Crude wood extract. The ethanol was recovered by a rotary evaporator, and evaporated until there was no alcohol smell, to obtain the lycopodium concentrate, which was centrifuged for 10 minutes (5000r / min), and the supernatant was taken, and purified by macroporous resin. Select SP825L resin, the ratio of diameter to height is 1:5, the maximum sample loading is 0.35g of crude drug per gram of dry resin, and the adsorption flow rate is 1BV / h; the impurity removal solvent is 0.1% glacial acetic acid, the dosage is 4BV, and the impurity removal solvent flow rate The enric...

Embodiment 2

[0045] Example 2, preparation and characterization of the present invention's total phenolic acid pellets

[0046] 1. The preparation of the total phenolic acid pellets of S. japonicus of the present invention

[0047] The present invention adopts extruding and spheronizing method to prepare the total phenolic acid pellets of S. chinensis, and the raw materials of the total phenolic acids of S. 10.5g, silicon dioxide 6.75g. Among them, microcrystalline cellulose and lactose are used as diluents; silicon dioxide is used as an anti-adhesive agent; the drug loading of the total phenolic acid pellets prepared by S. chinensis is 28.7%. Drug loading=mass of total phenolic acids of S. chinensis / (mass of total phenolic acids of S. chinensis+total mass of other raw materials)×100%, wherein other raw materials are microcrystalline cellulose, lactose and silicon dioxide.

[0048] Preparation process parameters: the extrusion speed is 43r / min, the spheronization speed is 1800r / min, and ...

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Abstract

The invention provides rhus chinensis total phenolic acid micropellets and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The rhus chinensis total phenolic acid micropellets are prepared from the following raw materials in parts by weight: 35-55 parts of rhus chinensis total phenolic acid, 75-115 parts of microcrystalline cellulose, 8-13 parts of lactose,and 5-8 parts of silicon dioxide. The method provided by the invention adopts an extrusion-spheronization process, overcomes the problems that micropellets are difficult to prepare due to strong hygroscopicity and strong viscosity of rhus chinensis total phenolic acid in the prior art by selecting a specific raw material ratio and specific process parameters, and prepares the rhus chinensis totalphenolic acid micropellets with good pelleting performance and a high yield. The rhus chinensis total phenolic acid micropellets obtained by the preparation method have very high drug loading capacityand can meet clinical needs; at the same time, the preparation method has good reproducibility and is beneficial to large-scale industrial production; and the method can guide the production environment of GMP when put into production in the future, and provide a theoretical reference basis for the industrial production of the rhus chinensis total phenolic acid micropellets.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a kind of total phenolic acid pellets and a preparation method thereof. Background technique [0002] Saltwood (Rhuschinensis M.), also known as Galla, sycamore, yellow-fleshed sour barrel, skinwood, etc., is a small deciduous tree of the Anacardaceae Rhuschinensis genus. Its fruits, leaves, flowers, roots, root bark, bark, Insect galls can be used as medicine, which has the effects of clearing heat and detoxifying, dispelling blood stasis and stopping bleeding. The total phenolic acid of Salmonella is one of the extracts of Salmonella, which has a protective effect on acute myocardial ischemia. At present, the preparations of P. chinensis and total phenolic acids of P. chinensis are mainly syrups and the like. For example: Fuzhou Neptune Golden Elephant Traditional Chinese Medicine Pharmaceutical Co., Ltd. conducts research and development on Yanfumu, a...

Claims

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Application Information

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IPC IPC(8): A61K36/22A61K9/20A61P9/10
CPCA61K36/22A61K9/2054A61P9/10A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55
Inventor 徐伟王晓颖禇克丹林羽许文叶淼
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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