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New Application of Xiaochaihu Granules Combined with Chloroquine Phosphate

A technology of Xiaochaihu granules and chloroquine phosphate, which is applied in the directions of medical preparations, drug combinations, and antibacterial drugs containing active ingredients, can solve the problems of accelerated improvement of clinical symptoms, inferior virus clearance, and insignificant curative effect, etc. Reduce the content, improve the sensitization effect, and improve the effect of free radical scavenging ability

Active Publication Date: 2022-01-07
GUANGZHOU BAIYUSN GUANGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The latest clinical research shows that lopinavir, ritonavir (Kaletra) and Arbidol for the treatment of novel coronavirus pneumonia are not superior to the control group in terms of improving clinical symptoms and accelerating virus clearance, and the curative effect is not significant

Method used

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  • New Application of Xiaochaihu Granules Combined with Chloroquine Phosphate
  • New Application of Xiaochaihu Granules Combined with Chloroquine Phosphate
  • New Application of Xiaochaihu Granules Combined with Chloroquine Phosphate

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Effect test

Embodiment 1

[0041] The present invention finds that the minimum inhibitory concentration of Xiaochaihu granules to the standard strain of Mycoplasma pneumoniae FH is 3.125 mg / mL through the in vitro antibacterial test of the standard strain of Mycoplasma pneumoniae, and the minimum inhibitory concentration of chloroquine phosphate tablets to the standard strain of Mycoplasma pneumoniae FH is 8 mg / mL. mL, Xiaochaihu granules combined with azithromycin can significantly reduce the minimum inhibitory concentration of azithromycin (0.002mg / ML→0.0005mg / mL), and Xiaochaihu granules+chloroquine phosphate tablets combined with azithromycin can significantly reduce the minimum inhibitory concentration of azithromycin (0.002mg / ML→0.0005mg / mL). ML→0.000125mg / mL), indicating that Xiaochaihu granules, Xiaochaihu granules combined with azithromycin, Xiaochaihu granules + chloroquine phosphate tablets combined with azithromycin can significantly inhibit Mycoplasma pneumoniae in vitro, that is, it is found...

Embodiment 2

[0057] The present invention uses the SD rat model infected by Mycoplasma pneumoniae to conduct experiments, and finds that Xiaochaihu granules, especially Xiaochaihu granules combined with chloroquine phosphate tablets can significantly increase glutathione peroxidase, superoxide dismutase, peroxidase The level of hydrogenase can reduce the content of malondialdehyde, and its effect is stronger than that of Xiaochaihu granules and chloroquine phosphate alone, indicating that the combined administration can improve the body's ability to scavenge free radicals and reduce the cytotoxicity caused by free radical accumulation, that is, the discovery of Xiaochaihu granules Combined with chloroquine phosphate tablets, it has the purpose of eliminating excessive free radicals caused by Mycoplasma pneumoniae infection.

[0058] The use of Xiaochaihu Granules combined with Chloroquine Phosphate Tablets for removing excess free radicals caused by Mycoplasma pneumoniae infection is furthe...

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Abstract

The present invention uses the SD rat model infected by Mycoplasma pneumoniae to conduct experiments, and finds that Xiaochaihu granules can remove excess free radicals caused by Mycoplasma pneumoniae infection. In particular, the combination of Xiaochaihu granules and chloroquine phosphate can significantly increase serum glutathione Glycerin peroxidase, superoxide dismutase, and catalase levels reduced the content of malondialdehyde, indicating that combined administration can improve the body's ability to scavenge free radicals and reduce the cytotoxicity caused by free radical accumulation. Xiaobupleurum granules were found Combined with chloroquine phosphate tablets, it has the function of removing excess free radicals caused by Mycoplasma pneumoniae infection, solves the problem of excessive free radicals in Mycoplasma pneumoniae infection, and has a better sensitization effect on azithromycin, so it can be used to prevent and treat Mycoplasma pneumoniae.

Description

technical field [0001] The invention relates to a new application of Xiaobupleurum granules combined with chloroquine phosphate, and belongs to the field of combined Chinese and Western medicines. Background technique [0002] Mycoplasma pneumoniae is the pathogen of primary atypical pneumonia in humans and one of the most common pathogens of community-acquired pneumonia in my country. Mycoplasma pneumoniae infection is mainly transmitted through droplets, which can cause upper and lower respiratory diseases such as pharyngitis, bronchitis, and acute pneumonia, and can also cause complications such as encephalitis, radiculitis, myocarditis, and hemolytic anemia. Macrolide antibiotics are the first choice for its treatment. However, studies have shown that the in vitro resistance rate of Mycoplasma pneumoniae in my country to macrolide antibiotics is significantly higher than that in other countries. Therefore, we should be vigilant and try other drug combinations. The lates...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K31/4706A61P11/00A61P31/04A61P39/06
CPCA61K36/233A61K36/539A61K36/8888A61K36/344A61K36/9068A61K36/484A61K36/725A61K31/4706A61P11/00A61P31/04A61P39/06A61K2300/00
Inventor 刘宏张俊华毕聪郑如文江志强何逸禧杜海泳
Owner GUANGZHOU BAIYUSN GUANGHUA PHARMA
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