Micro-fluidic chip and use method thereof

Abstract

The invention discloses a micro-fluidic chip and a use method thereof. The micro-fluidic chip comprises a first substrate and a second substrate, which are oppositely arranged; the first substrate comprises a first under-layer substrate, and a plurality of electrochromic structures and a driving circuit, which are positioned on one side facing the second substrate; a gap for storing liquid drops is formed between the first substrate and the second substrate; and a driving circuit is used for controlling the electrochromic structure at the position of the liquid drop to transmit light in the detection stage, so that external exciting light penetrates through the electrochromic structure and is emitted to the liquid drop. A plurality of electrochromic structures and a driving circuit are arranged in the first substrate; in the detection stage, the driving circuit can control the electrochromic structure at the position of the liquid drop to transmit light, so that external exciting lightpenetrates through the electrochromic structure and is emitted to the liquid drop, the liquid drop is driven to generate fluorescence excitation, optical detection of the liquid drop at any positionis achieved, and the optical detection efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of trace detection, in particular to a microfluidic chip and a method for using the same. Background technique [0002] The laboratory on a chip can integrate the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip, and automatically complete the entire analysis process. Due to the low cost of the laboratory on a chip, the detection time Short, high sensitivity and other advantages, has shown great prospects in the fields of biology, chemistry, medical reaction and separation. [0003] Among them, the microfluidic chip can automatically prepare and manipulate samples in the form of droplets. Optical detection can be used for sample detection. However, the magnitude of the optical signal generated by the sample is directly related to the intensity and accuracy of the excitation light. Relate...

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Problems solved by technology

[0004] Embodiments of the present invention provide a microfluidic chip and a method of using the same to solve the problem of low optical detection efficiency of the microfluidic chip in the prior art

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