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Application of plasma small extracellular vesicle miR-431-5p

A technology of small cells and vesicles, applied in the field of biomedicine, can solve problems such as patent publications that have not yet been found, and achieve timely diagnosis and broad application prospects

Active Publication Date: 2020-07-10
天津医科大学眼科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still few sEVs miRNA studies that can be found in DR
[0004] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Application of plasma small extracellular vesicle miR-431-5p
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  • Application of plasma small extracellular vesicle miR-431-5p

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Embodiment Construction

[0022] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0023] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0024] Use of plasma small extracellular vesicles miR-431-5p as a marker for the diagnosis of diabetic retinopathy.

[0025] Application of plasma small extracellular vesicle miR-431-5p as a target for the preparation of drugs for the treatment of diabetic retinopathy.

[0026] The above extraction and detection method of plasma small extracellular vesicles miR-431-5p, the steps can be as follows:

[0027] (1) Extraction of plasma

[0028] Take 10ml of whole blood from each patient into an EDTA anticoagulant tube, c...

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Abstract

The invention relates to an application of plasma small extracellular vesicle miR-431-5p as a marker of diabetes retinopathy diagnosis. It is firstly found that the expression level of miR-431-5p in plasma sEVs is closely related to diabetes retinopathy, and whether a subject has the risk of diabetes retinopathy or not can be judged more accurately and rapidly by detecting the expression of miR-431-5p in plasma sEVs of a diabetes patient; therefore, a prevention or treatment scheme is provided for clinicians, a new diabetes target and a new treatment pathway are provided for treating diabetesretinopathy as a target for preparing drugs for treating diabetes retinopathy, and compared with a traditional detection means, the diagnosis of molecular biomarkers is more timely and specific, so that the retinopathy process of the diabetes patient is predicted, early intervention and treatment are achieved, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to the application of plasma small extracellular vesicle miR-431-5p. Background technique [0002] Extracellular vesicles (EVs) are a variety of nanoscale vesicles released by cells. Vesicles of similar size can be further classified according to their biogenesis process, size, and physiological properties, such as microvesicles (MVs) and exosomes. MVs arise from the "budding" of the plasma membrane, shed directly from the cell, and vary in diameter from 100-1000 nm. Exosomes are extracellular vesicles with a diameter of 30-100 nm. In the late 1980s, Johnstone RM et al. discovered the existence of exosomes in the extracellular space. Small EVs (small EVs, sEVs) with a diameter of less than 200nm can be separated by traditional differential centrifugation, and their main components are exosomes. According to the expert consensus released in 2018, since it is difficult to direc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/178
Inventor 李筱荣张晓敏肖梦然杨付花
Owner 天津医科大学眼科医院
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