Preparation method and application of titanium dioxide nano composite material

A nanocomposite material, titanium dioxide technology, applied in the field of nanomedical materials, can solve the problems of double infection of drug-resistant bacteria, drug resistance, antibiotic ineffectiveness, etc., and achieve the effect of extensive antiviral activity

Pending Publication Date: 2020-07-31
HARBIN NORMAL UNIVERSITY
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Problems solved by technology

Bacterial infection is a systemic infection caused by pathogenic bacteria or conditional pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites, especially the elderly, children, people with chronic diseases or low immune function may develop sepsis or sepsis Hyperemia, the use of antibiotics to treat bacterial infections often leads to bacterial resistance, making antibiotics ineffective, leading to superinfection of drug-resistant bacteria

Method used

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  • Preparation method and application of titanium dioxide nano composite material

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specific Embodiment approach 1

[0025] In this example, chlorophyll-a (PPa), the degradation product of chlorophyll, is used as an organic photosensitive molecule, titanium dioxide is used as an inorganic semiconductor nanomaterial as a carrier, and modified with polyethylene glycol to obtain TiO 2 @SiO 2 / PPa@PEG nanocomposites.

[0026] like figure 1 As shown, the specific operation process is as follows:

[0027] (1) TiO 2 Preparation of nanoparticles: Add 0.5 g of L-ascorbic acid into a beaker with 70 mL of double distilled water, and stir at room temperature for 10 min. Then add 6g of titanium trichloride TiCl 3 , forming a purple solution. Then NaOH solution (1 mol / L) was added until the pH was 4. After stirring at room temperature for another 30 min, the mixture was transferred to a 100 mL Teflon-lined stainless steel autoclave and heated at 180 °C for 12 h. The resulting precipitate was collected by centrifugation, washed with water and ethanol, and then dried overnight at 80 °C to obtain TiO ...

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Abstract

The invention discloses a preparation method of a titanium dioxide nano composite material, and belongs to the technical field of nano medical materials. The invention provides a medical composite material with wide antiviral activity, antibacterial activity and anticancer activity, and provides the preparation method of the titanium dioxide nano composite material. According to the invention, titanium dioxide is used as an inorganic semiconductor nano material as a carrier, encapsulation of organic photosensitive molecules is carried out, and biocompatible macromolecules are used for surfacemodification. The prepared material has wide antiviral activity, antibacterial activity and anticancer activity, and the biological activity of the material destroys viruses, bacteria and nucleic acids, proteins, lysosomes and mitochondria of bacterial and infected cells based on active oxygen generated by photocatalysis, so that the viruses, bacteria and cancer cells cannot be copied, and tissuenutrients cannot be supplied, thereby killing the viruses, bacteria and cancer cells. The nano composite material provided by the invention can also be used as a protective material for medical treatment and public health, including medical masks, protective clothing, gloves, disinfectants and the like.

Description

technical field [0001] The invention relates to a preparation method and application of a titanium dioxide nanocomposite material, belonging to the technical field of nanomedical materials. Background technique [0002] The core of the virus is ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and the outer shell is protein, which parasitizes in the host cell, such as SARS virus, new coronavirus, Ebola virus, etc. in some animal cells, through human Infected through contact with animals, until the consequences of human-to-human transmission occur. Viruses rely on the host cell's metabolic system for proliferation and replication. Viruses synthesize viral nucleic acids and proteins in host cells, assemble into infectious virions, and release them from cells to infect other cells. Viral diseases are the main infectious diseases of humans. Common diseases caused by viruses include influenza, common cold, pneumonia, measles, mumps, polio, infectious hepatitis, hepatitis B...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/02A61P31/04A61P31/12A61P35/00A41D31/30
CPCA61K41/0071A61K41/0057A61K47/02A61P31/04A61P31/12A61P35/00A41D31/30
Inventor 谭广慧金英学王志强杨陈
Owner HARBIN NORMAL UNIVERSITY
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