Device for ion generation, transmission and mass spectrometry of a low-vacuum system

An ion transmission, low vacuum technology, applied in the field of analysis and testing, can solve the problems of low writing sensitivity of the instrument device, reduced system detection sensitivity, weak ion signal, etc., to improve the analysis speed and accuracy, save the sample pretreatment process, The effect of reducing maintenance costs

Pending Publication Date: 2020-07-31
常州磐诺仪器有限公司
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AI Technical Summary

Problems solved by technology

[0006] At present, in ion mobility spectrometry and mass spectrometry instruments, generally the ion source generates ions and enters the ion mobility spectrometer directly, or an ion lens is placed at the front end of the ion mobility spectrometer as the ion transmission system, but this ion transmission system is in the ion mobility During the transmission process, the ions can only be transmitted in a straight line and cannot be bound by the radio frequency electric field. The ions are easy to diverge and be lost, re...

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  • Device for ion generation, transmission and mass spectrometry of a low-vacuum system
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  • Device for ion generation, transmission and mass spectrometry of a low-vacuum system

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Embodiment 1）

[0035] See figure 1 , the present invention comprises a primary vacuum chamber 116, a secondary vacuum chamber 117, a tertiary vacuum chamber 118 and a fourth vacuum chamber 119 connected in sequence; the primary vacuum chamber 116 is provided with an ion source for generating the sample ions to be measured, for transmission The primary ion transmission system 105 for the sample ions to be measured generated by the ion source and the vacuum pump ventilation interface 104 for introducing auxiliary gas; the ion source is loaded with a desolvation device 102 to improve ionization efficiency; the desolvation device 102 A capillary 101 is provided throughout; the primary ion transport system 105 is an ion funnel; the secondary vacuum chamber 117 is provided with an ion mobility spectrometer 106 for separating the isomers of the sample ions to be measured; the tertiary vacuum chamber 118 is A secondary ion transmission system 107 for transmitting the sample ions to be measured produ...

Embodiment 2）

[0042] This embodiment is basically the same as Embodiment 1, the difference is that in the secondary ion transmission system 107, a multi-stage rod is used as the ion transmission system, and the multi-stage rod is a quadrupole rod, a hexapole rod, an octopole rod, a ten-pole rod, etc. Poles, 12 poles, 16 poles, etc.

[0043] The ion mobility spectrometer 106 is differential ion mobility spectroscopy, transfer tube ion mobility spectroscopy or high-field asymmetric waveform mobility spectroscopy.

[0044] The ion mass analyzer 108 is one or more of a quadrupole mass analyzer, a time-of-flight mass analyzer, an ion trap mass analyzer, a magnetic mass analyzer, a Fourier cyclotron resonance mass analyzer, or an orbital ion trap mass analyzer Various.

Embodiment 3）

[0046] This embodiment is basically the same as Embodiment 1, and the difference is that the secondary ion transmission system 107 is a combination of an ion funnel and a multistage rod, and the ion transmission efficiency is improved through different ion transmission systems, neutral molecules are removed, and the instrument is improved. system sensitivity.

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Abstract

The invention relates to the technical field of analytical testing, in particular to a device for ion generation, transmission and mass spectrometry of a low-vacuum system, which comprises an ion source, a primary ion transmission system, an ion mobility spectrometry, a secondary ion transmission system and an ion mass analyzer. A vacuum system of the device has a multi-stage vacuum differential function; wherein the ion source is placed in a chamber with a lower vacuum degree, sample ions to be detected generated by the ion source are efficiently transmitted to the ion mobility spectrometry through the primary ion transmission system and enter the secondary ion transmission system to be efficiently transmitted to the ion mass analyzer after being separated by the ion mobility tube; the device system can improve the ion generation efficiency and the ion transmission efficiency and realize the separation of the ion isomers, thereby improving the ion separation efficiency, the ion transmission efficiency and the detection sensitivity of the whole system.

Description

technical field [0001] The invention belongs to the technical field of analysis and testing, and in particular relates to a device for ion generation, transmission and mass spectrometry in a low vacuum system. Background technique [0002] Ion mobility spectrometry technology refers to the separation of different ions with different mobility under the action of an electric field under low vacuum conditions. It has the advantages of simple structure and fast analysis speed. It is mainly used for online rapid detection of explosives and drugs. Airports, stations, immigration and other occasions. However, due to the low resolving power of ion mobility spectrometry, problems such as false positives or missed negatives are prone to occur when detecting complex mixtures. Therefore, a series of various coupled instrument technologies have emerged to improve the resolving power of ion mobility spectrometry, such as gas chromatography-ion mobility spectrometry, ion mobility spectrom...

Claims

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Application Information

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IPC IPC(8): H01J49/00H01J49/04H01J49/06H01J49/10H01J49/16
CPCH01J49/004H01J49/0404H01J49/044H01J49/067H01J49/107H01J49/165
Inventor 徐福兴吴芳玲闫迎华余绍宁丁传凡
Owner 常州磐诺仪器有限公司
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