Device for ion generation, transmission and mass spectrometry of a low-vacuum system

Abstract

The invention relates to the technical field of analytical testing, in particular to a device for ion generation, transmission and mass spectrometry of a low-vacuum system, which comprises an ion source, a primary ion transmission system, an ion mobility spectrometry, a secondary ion transmission system and an ion mass analyzer. A vacuum system of the device has a multi-stage vacuum differential function; wherein the ion source is placed in a chamber with a lower vacuum degree, sample ions to be detected generated by the ion source are efficiently transmitted to the ion mobility spectrometry through the primary ion transmission system and enter the secondary ion transmission system to be efficiently transmitted to the ion mass analyzer after being separated by the ion mobility tube; the device system can improve the ion generation efficiency and the ion transmission efficiency and realize the separation of the ion isomers, thereby improving the ion separation efficiency, the ion transmission efficiency and the detection sensitivity of the whole system.

Description

technical field [0001] The invention belongs to the technical field of analysis and testing, and in particular relates to a device for ion generation, transmission and mass spectrometry in a low vacuum system. Background technique [0002] Ion mobility spectrometry technology refers to the separation of different ions with different mobility under the action of an electric field under low vacuum conditions. It has the advantages of simple structure and fast analysis speed. It is mainly used for online rapid detection of explosives and drugs. Airports, stations, immigration and other occasions. However, due to the low resolving power of ion mobility spectrometry, problems such as false positives or missed negatives are prone to occur when detecting complex mixtures. Therefore, a series of various coupled instrument technologies have emerged to improve the resolving power of ion mobility spectrometry, such as gas chromatography-ion mobility spectrometry, ion mobility spectrom...

AI Technical Summary

Problems solved by technology

[0006] At present, in ion mobility spectrometry and mass spectrometry instruments, generally the ion source generates ions and enters the ion mobility spectrometer directly, or an ion lens is placed at the front end of the ion mobility spectrometer as the ion transmission system, but this ion transmission system is in the ion mobility During the transmission process, the ions can only be transmitted in a straight line and cannot be bound by the radio frequency electric field. The ions are easy to diverge and be lost, resulting in most of the ions lost during the transmission process not entering the ion mobility spectrometer or mass spectrometry analysis, resulting in the loss of the entire instrument. low write sensitivity

[0007] In the previous investigation, it was found that after the ion source under normal pressure generates ions, about 90% of the ions will be lost in the process of entering the ion transmission system under low vacuum, which directly affects the detection of the entire system Reduced sensitivity, weak ion signal, etc.

Images