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Compositions and methods for protecting against airborne pathogens and irritants

A composition and drug technology, applied in the direction of biochemical equipment and methods, resistance to vector-borne diseases, drug combinations, etc., can solve the problems of no convenience

Pending Publication Date: 2020-08-21
APPLIED BIOLOGICAL LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there is no easy, effective way to minimize or prevent infection or allergy from inhaled or ingested microorganisms

Method used

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  • Compositions and methods for protecting against airborne pathogens and irritants
  • Compositions and methods for protecting against airborne pathogens and irritants
  • Compositions and methods for protecting against airborne pathogens and irritants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0327] Example 1: Administration of antimicrobial compositions to prevent infection in non-human subjects

[0328] Various concentrations of antimicrobial compositions containing the ingredients of Table 1 were intranasally administered to a group of healthy, uninfected mice selected by age, sex and body weight. After an appropriate time for the composition to take effect, the mice were inoculated intranasally with different doses of respiratory pathogens (influenza, rhinovirus, bacteria and fungi). At various subsequent time points, samples were extracted from the mice and analyzed for microbial infection. The absence of infection indicates that the antimicrobial composition prevented infection of the mice with airborne pathogens. The antimicrobial composition enhances the filtering capacity of the nasal membranes and protects against airborne pathogens.

Embodiment 2

[0329] Example 2: Administration of Antimicrobial Compositions to Treat Infections in Non-Human Subjects

[0330] A group of healthy, uninfected mice selected by age, sex, and body weight were inoculated nasally with varying doses of respiratory pathogens (influenza, rhinoviruses, bacteria, and fungi). After an appropriate period of time allowing the pathogen to infect the mice, different concentrations of an antimicrobial composition (eg, Example 1) comprising the ingredients of Table 1 were administered intranasally to the infected mice. After a suitable time to allow the composition to work, samples are extracted from the mice and analyzed for microbial infection. The absence of infection indicates that the antimicrobial composition can treat respiratory infections in mice. The antimicrobial composition enhances the filtering capacity of nasal membranes and treats infections caused by airborne pathogens.

Embodiment 3

[0331] Example 3: Administration of antimicrobial compositions to treat infections in human subjects

[0332] A cohort of human subjects without pre-existing influenza or rhinovirus infection were selected for treatment and their baseline blood was drawn to screen for markers of respiratory tract infection. An antimicrobial composition (eg, Examples 1 and 2) containing the ingredients of Table 1 was administered intranasally to the subject. After a suitable period of time for the composition to take effect, the subject is exposed to airborne rhinovirus or influenza. After an appropriate period of time to determine whether they have been infected, blood will be drawn again and screened for systemic markers of respiratory infection, and they will be observed and asked for evidence of respiratory infection. The absence of infection indicates that the antimicrobial composition prevents respiratory infection. The antimicrobial composition enhances the filtering capacity of nasa...

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Abstract

The present disclosure features methods and compositions for enhancing the ability of the respiratory membranes to filter airborne pathogens and protect a subject from respiratory infections that result from inhalation or ingestion of such pathogens. In particular, the disclosure provides antimicrobial compositions that prevent and treat respiratory infections caused by bacteria, fungi, and viruses.

Description

[0001] This application claims priority to US Application Serial No. 15 / 691,648, filed August 30, 2017, the entire contents of which are incorporated herein by reference. U.S. Application No. 15 / 691,648 is a continuation-in-part of U.S. Application No. 15 / 442,604 filed February 24, 2017, and U.S. Application No. 15 / 442,604 requires the U.S. Provisional Application serial number filed February 25, 2016 to be Priority of 62 / 299,755, the entire contents of each application are hereby incorporated by reference in their entirety. technical field [0002] The present disclosure relates to compositions and methods for enhancing the health and filtering capacity of the upper airway epithelium and mucosa. In particular, the present disclosure relates to methods for protecting the epithelium and mucous membranes of a subject from infection by airborne pathogens such as viruses, bacteria and fungi and from unwanted airborne particles such as allergens, irritants or odorants. Stimulating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/17A61K38/40A61K38/47A61K31/351A61K31/352A61K36/752A61K33/30A61K33/34A61K33/38A61P31/14A61P31/16A23L33/10A23L33/105A23L33/115A23L33/15A23L33/17A23L3/3526
CPCA61K38/177A61K38/40A61K38/47A61K45/06C12Y302/01017A61K9/0043A61K9/006A61P11/00A61P31/00A61K31/7012A61K9/0019A61K9/0073A61K31/352A61K31/7016A61K33/30A61K33/34A61K33/38A61K36/28A61K36/328A61K36/53A61K36/752A61K38/1774A61K47/10A61K47/26A61K47/44C12N9/24A61K2300/00A61K33/40A61K31/731A61K31/05C12N2760/16263
Inventor N·拉特菲
Owner APPLIED BIOLOGICAL LAB INC