Inorganic rapid hemostatic material and preparation method thereof

A hemostatic material and rapid technology, applied in the fields of medical formula, medical science, bandages, etc., can solve the problems of limited adhesion of hemostatic materials, difficulty in follow-up treatment, and reduced hemostatic ability, so as to facilitate cell proliferation and epithelialization, and promote The effect of wound healing and strong liquid absorption ability

Active Publication Date: 2020-09-01
湘潭海美斯泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned hemostatic materials have the following problems: the amount of adhesion of the hemostatic material is limited, and the particles adhering to the substrate are easy to fall off, which will lead to the reduction of its hemostatic ability and the difficulty of subsequent processing.
The preparation method and application of this sepiolite composite material have not been reported

Method used

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  • Inorganic rapid hemostatic material and preparation method thereof
  • Inorganic rapid hemostatic material and preparation method thereof
  • Inorganic rapid hemostatic material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment approach 1

[0028] The purpose of the first embodiment of the present invention is to provide an inorganic rapid hemostatic material, the preparation steps are as follows:

[0029] (a) Take 20g sepiolite raw material and mix and grind with 2ml deionized water, after grinding, add 300ml deionized water and stir to form suspension A, carry out centrifugation to suspension A, scrape the upper precipitate and disperse in In deionized water, a suspension B is formed;

[0030] (b) Add hydrochloric acid solution to the suspension B to acidify to PH = 3, let it settle, take the precipitate and continue to disperse it in deionized water, repeat the acidification 3 times. Take the precipitate and disperse it in deionized water to form a suspension C, then add sodium hydroxide solution to the suspension C until PH = 9, let it settle, take the sediment and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Take the precipitate and disperse it in 200ml of satu...

Embodiment approach 2

[0036] The purpose of the second embodiment of the present invention is to provide an inorganic rapid hemostatic material, the preparation steps are as follows:

[0037](a) Take 20g sepiolite raw material and mix and grind with 2ml deionized water, after grinding, add 300ml deionized water and stir to form suspension A, carry out centrifugation to suspension A, scrape the upper precipitate and disperse in In deionized water, a suspension B is formed;

[0038] (b) Add hydrochloric acid solution to the suspension B to acidify to PH = 3, let it settle, take the precipitate and continue to disperse it in deionized water, repeat the acidification 3 times. Take the precipitate and disperse it in deionized water to form a suspension C, then add sodium hydroxide solution to the suspension C until PH = 9, let it settle, take the sediment and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Take the precipitate and disperse it in 200ml of satu...

Embodiment approach 3

[0044] The purpose of the second embodiment of the present invention is to provide an inorganic rapid hemostatic material, the preparation steps are as follows:

[0045] (a) Take 20g sepiolite raw material and mix and grind with 2ml deionized water, after grinding, add 300ml deionized water and stir to form suspension A, carry out centrifugation to suspension A, scrape the upper precipitate and disperse in In deionized water, a suspension B is formed;

[0046] (b) Add hydrochloric acid solution to the suspension B to acidify to PH = 3, let it settle, take the precipitate and continue to disperse it in deionized water, repeat the acidification 3 times. Take the precipitate and disperse it in deionized water to form a suspension C, then add sodium hydroxide solution to the suspension C until PH = 9, let it settle, take the sediment and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Take the precipitate and disperse it in 200ml of sat...

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Abstract

The invention discloses an inorganic rapid hemostatic material and a preparation method thereof. The inorganic rapid hemostatic material is sepiolite fibers. The inorganic rapid hemostatic material has the following beneficial effects: 1, the inorganic rapid hemostatic material has the characteristics of quickly stopping bleeding of wounds, promoting wound healing, absorbing body fluid and maintaining the humidity of the wounds; 2, the liquid absorption capability is very strong, and the highest water absorption capability can reach 100%-120% of the mass of the material; 3, the hemostatic effect is good, the local concentration of platelets is increased, fibrin networking is promoted, and therefore the purpose of rapid hemostasis is achieved; 4, the humidity of a wound surface can be adjusted, the hemostatic material is high in water retention capacity, can be slowly released after absorbing wound secretion and moisture, can keep the humidity of the wound surface and is beneficial to cell proliferation and epithelization, so that wound healing is promoted, and silver nano particles attached to sepiolite fibers have sterilization and anti-infection effects; 5, the porosity is high,oxygen can pass through, bacteria are isolated, and tissue growth is facilitated; 6, the hemostatic material does not contain any organic solvent, binder or other toxic and harmful substances, and will not pollute the environment; and 7, the hemostatic material has good processability and hydrophilicity, so that the hemostatic material can be easily mixed with chitosan, alginate, and the like, andused as a wound auxiliary material.

Description

Technical field: [0001] The invention relates to an inorganic rapid hemostatic material and a preparation method thereof. Background technique: [0002] Rapid bleeding is often encountered in natural disasters, war conflicts, surgical operations and accidental accidents. If the bleeding cannot be controlled in time, it is easy to endanger the lives of the wounded. Currently reported are zeolite, oxidized cellulose, chitosan, alginate, collagen and starch polysaccharides for rapid hemostasis. These materials have their own advantages and disadvantages. For example, zeolite can easily cause tissue necrosis, and gelatin and cellulose can cause local adhesions. Mature products currently on the market include cellulose dressings with good biocompatibility and degradability, but their hemostatic effect is weak and they cannot inhibit bacterial growth inside the dressing. The American company Medafor uses absorbable hemostatic microspheres in hemostasis. The Aristay hemostatic po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/00A61L26/00
CPCA61L24/02A61L24/0015A61L26/0004A61L26/0066A61L2400/04A61L2400/12A61L2300/104A61L2300/404A61L2300/412A61L2300/10
Inventor 丁燕怀蒋运鸿彭张哲杨勇文欧阳东红姜文武梅昱帆
Owner 湘潭海美斯泰科技有限公司
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