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Process and system for propagating cell cultures while preventing lactate accumulation

A technology for cell culture and cell propagation, applied in the field of propagation of biological materials, can solve the problems of not being able to disclose the lactic acid concentration control system, not being able to provide robust control, etc.

Pending Publication Date: 2020-09-04
LONZA LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the aforementioned article not only fails to disclose a lactate concentration control system, but also fails to provide robust control of process parameters combined with feedback mechanisms

Method used

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  • Process and system for propagating cell cultures while preventing lactate accumulation
  • Process and system for propagating cell cultures while preventing lactate accumulation
  • Process and system for propagating cell cultures while preventing lactate accumulation

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Embodiment Construction

[0030] Those of ordinary skill in the art will understand that the present discussion is a description of exemplary embodiments only, and is not intended to limit the broader aspects of the disclosure.

[0031] In general, the present disclosure relates to methods and systems for producing biological products. For example, in one embodiment, the present disclosure relates to a method and system for propagating a cell culture in a bioreactor. Systems of the present disclosure may use open-loop or closed-loop control to monitor a quality attribute, such as one or more parameters in a bioreactor, and then automatically alter or alter the flow rate of that parameter affecting the flow of material into or out of the bioreactor.

[0032] In general, any suitable quality attribute may be monitored and controlled in cell culture in accordance with the present disclosure. In one embodiment, the system includes a predictive control module that can input not only actual cell culture mea...

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Abstract

A predictive model is described that can predict the parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can beused to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined, and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Description

[0001] priority claim [0002] This application is based on and claims priority to U.S. Provisional Patent Application Serial No. 62 / 588,464, filed November 20, 2017, and U.S. Provisional Patent Application Serial No. 62 / 747,311, filed October 18, 2018, both of which are adopted Incorporated herein by reference. Background technique [0003] A bioreactor is a device that can carry out a biological reaction or process on a laboratory or industrial scale and is widely used in the biopharmaceutical industry. Bioreactors can be used to produce all different types of biological products. For example, bioproducts can include cell cultures and materials derived from cell cultures including beverages, biofuels, bioenergy, biochemicals, antibiotics, amino acids, enzymes, monoclonal antibodies, monomers , proteins, food cultures, biopolymers, alcohol, flavors and fragrances, and more. In some embodiments, cell cultures can be grown for cell therapy. Cell therapy is the prevention, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12M1/36
CPCC12M41/32C12M41/48
Inventor B·J·唐尼J·M·施密特J·F·布赖特
Owner LONZA LTD
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