Use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia

A kind of technology of dihydroartemisinin and medicine preparation, applied in the field of medicine

A kind of technology of dihydroartemisinin and medicine preparation, applied in the field of medicine

CN111632048BActive Publication Date: 2021-09-21CHINA AGRI UNIV
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  • Use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia
  • Use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia
  • Use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] Preparation of basal diet for adult zebrafish

[0029] Adult zebrafish rations were prepared with dextrin as the sugar source, casein and gelatin as the protein source, soybean oil as the fat source, and 0.25% or 0.5% dihydroartemisinin (Sinopharm Group Chemical Reagent Beijing Co., Ltd.) was used as the diet of the treatment group. The composition and chemical analysis values ​​of the experimental diet are shown in Table 1-1. Each feed raw material is pulverized and passed through a 40-mesh sieve. After mixing evenly, about 40% of water is added, extruded into strips, dried and crushed into pellets of 1-2mm, and stored in a -20°C refrigerator for later use.

[0030] Table 1 Test diet composition and chemical analysis value (%, feeding basis)

[0031] Items DhA 0% DHA 0.25% DHA 0.5% Raw materialIngredients Casein 40.00 40.00 40.00 Gelatin 10.00 10.00 10.00 Dextrin 35.00 35.00 35.00 Soybean oil 6.00 6.00 6.00 ...

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Abstract

The invention proposes the use of dihydroartemisinin in the preparation of medicines, and the medicines are used for preventing or treating hyperammonemia. Therefore, it provides theoretical basis and application value for human or animal hyperammonemia treatment or auxiliary treatment medicine.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to the use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia. Background technique [0002] Ammonia is a colorless gas with a strong pungent odor and the molecular formula is NH 3 (MW 17), which is also one of the main components of smog, can form secondary organic aerosols, thereby increasing the threat of smog to public health. Under normal circumstances, ammonia in the body mainly synthesizes secondary metabolites-urea and glutamine through the liver urea cycle, and then excretes the metabolites through the kidneys for ammonia detoxification. However, in the case of liver disease or impaired function, the ammonia detoxification process is blocked, which can easily cause hyperammonemia. High concentrations of ammonia can cause destructive effects on multiple organ systems in the human body, such as ...

Claims

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Application Information

Patent Timeline
21 Sep 2021
Publication
CN111632048B
IPC
A61K31/357; A61K36/282; A61P39/02
CPC
A61K31/357; A61K36/282; A61P39/02
Inventors
武振龙; 杨鹰