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Kidney cancer full-thickness pathological section sampling method

A technology for pathological slices and kidney cancer, which is applied in medical experiments and biology fields, and can solve problems such as imperfect pathological methods, inability to accurately evaluate immune information of kidney cancer, and difficulty in obtaining the pathological level of kidney cancer

Pending Publication Date: 2020-09-15
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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Problems solved by technology

[0004] RCC specimens are rich in immune information at all levels, which can provide evidence for the selection of targets for subsequent immunotherapy. However, the current pathological methods for obtaining full-thickness sections of RCC are not yet perfect, and it is difficult to obtain and image level by human judgment alone. Completely corresponds to the pathological level of renal cancer, so it is impossible to accurately evaluate the immune information contained in the level of renal cancer

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  • Kidney cancer full-thickness pathological section sampling method
  • Kidney cancer full-thickness pathological section sampling method
  • Kidney cancer full-thickness pathological section sampling method

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Embodiment 1

[0030] The experimental method described below is to facilitate those skilled in the art to better understand this method of drawing materials and apply it to clinical research, and it is universal to general kidney cancer specimens; the Mimics software can be downloaded from the Internet or obtained through other means; 3D The mold is made using a 3D printing machine; the blade for sampling can use a common pathological blade.

[0031] A method for obtaining full-thickness pathological slices of renal cancer, comprising the steps of:

[0032] Step 1: Copy the CT imaging data of renal cancer: Obtain the CT imaging data of renal cancer, select the patients who are suspected of renal cancer on imaging and determine the operation method to be performed radical nephrectomy for the convenience of research, and copy the imaging data , the format is DICOM, select the copied enhanced CT image, the slice thickness is 5mm, because uneven enhancement can be seen in the cortical phase of ...

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Abstract

The invention discloses a kidney cancer full-thickness pathological section sampling method, and belongs to the field of biological and medical experiments. The kidney cancer full-thickness pathological section sampling method comprises the following steps: (1) copying kidney cancer CT imaging data; (2) drawing a kidney 3D model by using Mimics software; (3) selecting and marking a pathological layer; (4) carrying out 3D printing; and (5) taking kidney full-thickness pathological sections. The method overcomes the defects that a traditional manual sampling method is inaccurate in sampling, sampling is conducted based on feeling and experience, and the kidney cancer pathology cannot completely correspond to imaging, so that the kidney cancer pathology can be positioned more accurately on the corresponding level of the imaging; and the kidney cancer whole-layer pathology level obtained through the method can lay a foundation for follow-up research of kidney cancer iconomics, pathomics and molecular omics, and a thought is provided for research of kidney cancer immunotherapy targets.

Description

technical field [0001] The invention discloses a method for obtaining materials from renal cancer full-thickness pathological slices, belonging to the fields of biology and medical experiments. Background technique [0002] Renal carcinoma (RCC) is a malignant tumor originating from the epithelium of the urinary tubules of the renal parenchyma, including various subtypes of renal cell carcinoma originating from different parts of the urinary tubules. Immunotherapy for RCC has also become a research hotspot today. How to achieve RCC immunotherapy Individualized and precise medicine has become a difficult point in today's research. The basis of renal cancer immunotherapy is to find the molecular target for treatment. Through the study of renal cancer pathology, various pathological and histological information such as the pathological stage and immune infiltration mode of renal cancer can be interpreted, and then the molecular biological information of renal cancer can be obta...

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Application Information

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IPC IPC(8): G01N1/04G16H30/40
CPCG01N1/04G16H30/40
Inventor 杨德勇王建伯汪淑晶刘俊强曹天宇宗华凤陈奇伟刘地宽杨学翰黄红伟张宗宗
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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