Sample application instrument

Abstract

The invention relates to the technical field of medical instruments, and discloses a sample application instrument, which comprises a gas path module and a liquid path module comprising a liquid storage bin and a liquid conveying pipe. The gas path module is communicated with the liquid storage bin, and one end of the liquid conveying pipe is communicated with the liquid storage bin; the gas pathmodule adjusts the air pressure in the liquid storage bin so as to control liquid discharging of the other end of the liquid conveying pipe. According to the sample application instrument disclosed bythe invention, the liquid outlet of the liquid conveying pipe in the liquid path module is controlled by arranging the gas path module, the sample liquid is promoted to flow out of the liquid conveying pipe by utilizing micro-pressure, the sample liquid is controlled by the air pressure, and is contacted with a sample application plate at the dripping moment to form an array, so that sample application is completed. The sample application instrument simultaneously solves the technical problems of a non-contact injection sample application instrument and a contact needle sample application instrument, a semi-contact sample application method is innovated, and the sample application method has the advantages of large sample point volume, low requirement on sample application environment andhigh sample application speed, a problem of abrasion of a needle head of a sample application needle is solved, and the sample application instrument is suitable for large-scale industrial production.

Description

Technical field [0001] The present invention relates to the technical field of medical devices, in particular to a spotting instrument. Background technique [0002] A spotting instrument, such as a biochip spotting instrument, is used to quickly and accurately place reagents, such as oligonucleotides, antibodies, proteins and other biological reagents, on the spotting plate (aldehyde-modified glass slides, silicon Film, etc.) on. [0003] Classified according to the spotting method, the existing spotting instruments are divided into non-contact jet spotting instruments and contact needle spotting instruments. [0004] The non-contact jet spotting instrument usually uses a piezoelectric nozzle to control the amount of spray dots. The cavity and small nozzles are etched on the silicon wafer. The back of the cavity is pasted with piezoelectric ceramics, and voltage is applied to the piezoelectric ceramics during operation. , The piezoelectric ceramic produces deformation and drives t...

AI Technical Summary

Problems solved by technology

This method has a fast spotting speed, but the volume of the sprayed sample is very small. It is very difficult for the piezoelectric ceramic nozzle to deal with liquids with high viscosity, and it has high requirements for the spotting environment such as temperature and humidity. , it is difficult to meet the large-scale and mechanized production, and the cost is high

[0005] The contact pin spotting instrument makes the spotting pin directly contact with the surface of the solid support, and leaves the sample on the solid support. The spotting pin is usually a solid pin or a pen-tip slit pin, etc., and its influence on the spotting environment The requirements are low, but the sampling speed is slow, and the tip of the sampling needle is worn out by contact sampling, and the life of the sampling needle is short

Images