Application of agilawood extract

A technology of extracts and agarwood, applied in medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problems that cannot prevent or reverse the course of the disease, easily cause learning and interpersonal relationships, etc., and achieve the improvement and prevention of cranial nerves. Degeneration, enhance the effect of nerve growth

Inactive Publication Date: 2020-09-22
METATECH (AP) INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Most of the current medical methods for other cranial nerve-related diseases and symptoms are the same as Alzheimer's disease, and cannot prevent or reverse the course of the disease. There are only a few metho

Method used

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  • Application of agilawood extract
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  • Application of agilawood extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] see figure 1 . figure 1 It is a fluorescent imaging diagram showing the neurons in the hippocampal gyrus of the rat brain in an experiment of the present invention. β-Ⅲtubulin is a unique skeleton protein of nerve cells. After staining β-Ⅲtubulin, it can be seen that the neurites of nerve cells appear green under a fluorescent microscope. DAPI can penetrate the cell membrane and bind to DNA, and when observed under a fluorescent microscope, it appears blue, representing the location of the nucleus of nerve cells. In this experiment, the nerve cells were stained with β-Ⅲtubulin antibody and DAPI respectively, and the observed growth of neurite cells is shown in Figure 1. It can be seen that when the concentration of Agarwood extract (AEO) is 1 / 5M (1 / 5,000,000), the growth of its neurites is significantly better than that of the control group (control) without Agarwood extract (AEO), such as nerve The length of the process and the number of neurites.

Embodiment 2

[0048] see Figure 2A . Figure 2A It is a schematic diagram showing the various levels of neurites of biological brain nerve cells. In this cell experiment, the neurites extending from the cell body 20 in the nerve cell 2 were respectively observed. The neurites were divided into axons and dendrites, and the axons were further divided into primary axons 211, secondary axons 212, and tertiary axons. sudden 213. Dendrites are further divided into primary dendrites 221 and secondary dendrites 222. Axons and dendrites are responsible for transmitting and receiving electrochemical signals between different nerve cells 2 and are also the most important purpose of nerve cell 2 conduction. Therefore, the greater the number of neurites and the longer their length, the more and farther they are from other nerve cells that nerve cell 2 can contact, and the greater the number of possible synapses. When the network connection between nerve cells in the brain tissue is more When strong...

Embodiment 3

[0053] see Figure 5 . Figure 5 It is an image diagram showing the damage repair of mouse cerebral cortex nerve cells in the experiment of the present invention. In the third cell experiment, the ability of cell migration and repair was measured. The basic principle is: after the primary cerebral cortex cells are isolated and cultured, a blank area is artificially created on the overgrown monolayer of cells, called "scratch". or wound”, the cells at the damaged edge will extend their axons to regenerate and enter the blank area to speed up repair. This method is widely used to observe the effect of drugs on cell migration and axon regeneration repair. Equal numbers of cells were seeded on Petri dishes. Make scratches on the Petri dish after attaching (e.g. Figure 5 between the two dotted lines on the right), which breaks the connection between neurite cells. After a period of time, observe the growth status of nerve cells on the culture dish (such as Figure 5 between ...

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Abstract

The invention relates to a new application of an agilawood extract. Uses are to treat cranial nerve diseases suffered by an organism, ameliorate cranial nerve symptoms manifested by the organism, prevent cranial nerve diseases suffered by the organism, enhance or activate cranial nerve manifestations of the organism, or enhance nerve growth of the organism. The memory and the learning ability of organisms taking the agilawood extract are improved.

Description

technical field [0001] The present invention provides a new application of the extract of agarwood, especially as a health product or medicine for treating, improving or preventing cranial nerve-related diseases. Background technique [0002] According to epidemiological statistics, before 2040 in North America, neurodegenerative diseases will replace cancer as the second leading cause of death. Neurodegenerative diseases are also known as "silent epidemics". They usually occur in the elderly. Due to the gradual isolation of patients from society during the onset, and the lack of relevant medical knowledge, the general public is seldom aware of them. and pay attention. With the aging of the population structure, the number of patients with neurodegenerative diseases is increasing day by day. For family members, patients and the general public, the economic, psychological and lifestyle impacts are really difficult to estimate and bear. [0003] According to epidemiological ...

Claims

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Application Information

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IPC IPC(8): A61K36/835A61K9/72A61P25/28A61P25/16A61P25/14A61P25/08
CPCA61K36/835A61K9/0078A61P25/28A61P25/16A61P25/14A61P25/08
Inventor 杨滢臻陈宗基廖修祈邓安智
Owner METATECH (AP) INC
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