A template and tissue-engineered blood vessel that can be used to prepare tissue-engineered blood vessels with low stimulation and high compliance

Abstract

The invention belongs to the field of tissue engineering, and specifically relates to a template for preparing blood vessels for tissue engineering with low stimulation and high compliance. The template includes a skeleton body (1), an inner core (2) and an anti-exposure layer (3); The anti-exposure layer is arranged on the outer surface of the inner core; the skeleton body is arranged on the outer surface of the anti-exposure layer; the anti-exposure layer (3) includes degradable materials and divalent cobalt ions; the skeleton body includes a mesh fiber skeleton Floor. The beneficial effect of the present invention is that the formation of gaps from the degradation of the anti-bare layer can finally make the acellular matrix coat the surface of the inner cavity of the reticular fiber skeleton, reduce the exposure of fibers, and reduce the stimulation of blood coagulation; and the reticular fiber skeleton can make the prepared The tissue engineered blood vessel has good mechanical properties; the divalent cobalt ions in the anti-exposed layer can improve the compliance of the prepared tissue engineered blood vessel, reduce the incidence of intimal hyperplasia, and improve the tissue regeneration after implantation in vivo.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a template and a tissue engineered blood vessel which can be used for preparing low stimulation and high compliance tissue engineered blood vessels. Background technique [0002] Vascular disease is the most lethal disease in the world. The occurrence of this disease is often caused by stenosis or blockage of blood vessels, resulting in reduced blood flow and lack of nutrients, resulting in tissue or organ damage, usually manifested as coronary heart disease, cerebrovascular disease, peripheral arterial disease disease. According to the World Health Organization, by 2030, the number of people dying from cardiovascular-related diseases worldwide will increase to 23.3 million annually. Vascular transplantation is still a routine method for the treatment of these diseases. At present, the use of patient's own blood vessels (such as the great saphenous vein, bilateral i...

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Problems solved by technology

[0006] Second, the compliance of the blood vessel prepared by the above method is not good, and it will stimulate the excessive proliferation of smooth muscle cells after implantation in vivo, resulting in intimal hyperplasia;

[0007] Third, the outer surface of the tissue-engineered blood vessel prepared by subcutaneous implantation using the above-mentioned template is relatively smooth, and it is easy to slip after implantation, which reduces the integration rate of the blood vessel and the surrounding tissue of the implantation site;

[0008] Fourth, the regeneration of tissue engineering tubes prepared by the above method needs to be improved

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