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Molecular mechanism and early warning application of RBM8A gene influencing glioblastoma migration and invasion

A glioblastoma and molecular mechanism technology, applied in the field of genetic engineering, can solve the problems of little research on the mechanism of glioblastoma cell migration and invasion, and the mechanism that affects glioblastoma cell migration and invasion , to regulate cell cycle and apoptosis

Pending Publication Date: 2020-09-29
南宁市第一人民医院
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Problems solved by technology

However, the mechanism by which RBM8A affects the migration and invasion of glioblastoma cells remains unclear
[0003] In summary, there are very few studies analyzing the mechanism by which RBM8A promotes the migration and invasion of glioblastoma cells

Method used

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  • Molecular mechanism and early warning application of RBM8A gene influencing glioblastoma migration and invasion
  • Molecular mechanism and early warning application of RBM8A gene influencing glioblastoma migration and invasion
  • Molecular mechanism and early warning application of RBM8A gene influencing glioblastoma migration and invasion

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Embodiment Construction

[0022] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. The specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0023] In the prior art, the specific mechanism by which RBM8A promotes the migration and invasion of glioblastoma is still unclear. In order to solve the above technical problems, the present invention will be described in detail below in conjunction with specific analysis. The specific mechanism of RBM8A promoting the migration and invasion of glioblastoma has not been clearly reported yet. Therefore, the present invention selects the RBM8A gene as the main analysis content. The present invention preliminarily confirms that RBM8A is expressed in glioblastoma. On this basis, the present invention intends to further clarify the specific mechanism of ...

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Abstract

The invention relates to a molecular mechanism and early warning application of an RBM8A gene influencing glioblastoma migration and invasion. 1) Western blot analysis of RBM8A expression in a glioblastoma cell line; 2) effects of the lentivirus-medicated knockout RBM8A gene on glioblastoma cell migration and invasion; 3) the effects of the overexpressed RBM8A gene on glioblastoma migration and invasion; 4) Western's blot analysis and detection of Noch1, phosphorylated STAT3 (p-STAT3), total STAT3 (STAT3), phosphorylated H3 (p-H3), and total H3 in the cell line that interfere with the expression of the RBM8A gene, and a Notch / STAT3 pathway is found to be a mechanism of RBM8A-mediated glioblastoma migration and invasion. The invention provides a new idea for the treatment of glioblastoma, and provides a new way for the study of glioblastoma drug treatment targets.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and relates to a molecular mechanism and an early warning method for interfering with RBM8A gene expression to cause migration and invasion of glioblastoma. Background technique [0002] Glioblastoma is an intrinsic brain tumor that may occur at any age and is thought to arise from genetic alterations affecting glial stem or progenitor cells [Weller M, Wick W, Aldape K, et al. Glioma[J]. Nature Reviews Disease Primers, 2015:15017.]. High aggressiveness and poor prognosis are hallmarks of glioblastoma, and despite major advances in the treatment of glioblastoma, survival has not improved for patients with glioblastoma [Quinn, T, Ostrom , et al. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012. [J]. Neuro Oncology, 2015.]. Therefore, finding the mechanisms that mediate glioblastoma invasion will provide new insights...

Claims

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Application Information

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IPC IPC(8): C12N15/867C12N15/90C12N15/12G01N33/574C12Q1/02
CPCC12N15/86C12N15/907C07K14/4702G01N33/57407G01N33/57484G01N33/5029G01N33/5041C12N2740/15043C12N2800/107G01N2333/4703Y02A50/30
Inventor 邹东华陈子龙张春丽林燕李荣杰胡北泉覃刚
Owner 南宁市第一人民医院
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