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Application of daphnetin in preparation of medicine for treating psoriasis

A daphnetin and psoriasis technology, applied in the field of medicine, can solve the problems of long-term evaluation of safety, high price of biological agents, skin damage, etc., to improve psoriasis-like skin lesions, weaken excessive cell proliferation and inflammation Effects with few reactions and side effects

Inactive Publication Date: 2020-10-02
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of topical drugs such as vitamin D derivatives is likely to cause metabolic abnormalities; systemic drugs such as acitretin and methotrexate are prone to side effects such as skin damage and liver toxicity; biological agents are usually expensive and their safety needs long-term evaluation

Method used

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  • Application of daphnetin in preparation of medicine for treating psoriasis
  • Application of daphnetin in preparation of medicine for treating psoriasis
  • Application of daphnetin in preparation of medicine for treating psoriasis

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Embodiment Construction

[0042] The principles and features of the present invention will be described below in conjunction with specific drawings, and the examples given are only used to explain the present invention, not to limit the scope of the present invention.

[0043] 1. Experimental materials

[0044] HaCaT keratinocytes were purchased from the Kunming Cell Bank of the Chinese Academy of Sciences.

[0045] Fetal bovine serum, DMEM high-glucose medium and trypsin were purchased from Gibco.

[0046] Dimethyl sulfoxide (DMSO) was purchased from Sigma.

[0047] Daphnetin was purchased from Beijing Suolaibao Technology Co., Ltd., CAS number: 486-35-1, article number: SD8490, analytical standard, HPLC ≥ 98%. Daphnetin was dissolved in DMSO (100 mM) and stored at -80°C for future use.

[0048] IL-17A, IL-22, oncostatin M, IL-1α and TNF-α cytokines were all purchased from PeproTech.

[0049] CCK-8 reagent was purchased from Dongren Chemical Technology (Shanghai) Co., Ltd.

[0050] Trizol and pri...

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Abstract

The invention discloses an application of daphnetin in preparation of a medicine for treating psoriasis, and belongs to the technical field of medicines. Tests by the applicant show that the daphnetincan weaken HaCaT keratinocyte hyperproliferation and inflammatory response and improve the imiquimod-induced mouse psoriasis-like skin lesion condition, so that the daphnetin can be used for preparing the medicine for treating the psoriasis, a new application field of the daphnetin is opened up, a new medicine for treating the psoriasis is also opened up, and the daphnetin has positive pharmaceutical value and wide social significance.

Description

technical field [0001] The invention relates to the application of daphnetin in the preparation of medicine for treating psoriasis, belonging to the technical field of medicine. Background technique [0002] Psoriasis is a common chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation, parakeratosis, and inflammatory cell infiltration. The disease affects 1%-3% of the world's population, and the incidence rate is increasing year by year. At present, the commonly used therapeutic drugs in clinic mainly include topical drugs, systemic drugs, biological agents and so on. Long-term use of topical drugs such as vitamin D derivatives is likely to cause metabolic abnormalities; systemic drugs such as acitretin and methotrexate are prone to side effects such as skin damage and liver toxicity; biological agents are usually expensive and their safety needs long-term evaluation . [0003] At present, although the pathogenesis of the disease is still no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P17/06
CPCA61K31/37A61P17/06
Inventor 高进涛陈方如方华楠米敬漆琪杨梦娟
Owner GUILIN MEDICAL UNIVERSITY