Nuclear left shift and value range determination method and device, and cell analyzer

Abstract

The invention discloses a nuclear left shift and value range determination method and device, and a cell analyzer. The method comprises the following steps: acquiring optical signal intensity values of each cell of a neutrophil population, wherein the optical signal intensity values comprise a fluorescence intensity value and a scattered light intensity value; according to the distribution characteristics of the optical signal intensity values of the cells, obtaining at least one characteristic parameter of the neutrophil population, wherein the at least one characteristic parameter comprisesa morphological characteristic parameter, and the morphological characteristic parameter is used for representing the distribution form of the optical signal intensity values of the cells of the neutrophil population; and under the condition that the at least one characteristic parameter meets a preset nuclear left shift determination condition, determining that nuclear left shift occurs in the neutrophil population. According to the scheme provided by the embodiment of the invention, the influence of instrument difference, instrument debugging precision and other factors on the identificationresult can be reduced, and the universality of the nuclear left shift determination scheme of the neutrophil population is improved.

Description

technical field [0001] The present application relates to the field of blood analysis, in particular to a method, device and cell analyzer for nuclear left shift and value range determination. Background technique [0002] Neutrophils in blood can include mature neutrophils and immature neutrophils. If there is an increase in immature neutrophils in the blood, it is considered that the neutrophils have shifted to the left. [0003] At this stage, neutrophils are often divided by setting a dividing line or a fixed gate on the scatter plot. For example, neutrophils above the demarcation line or in a fixed gate were classified as suspected left-shifted cells. Then, the number of suspected left-shifted cells is counted, and if the counted number of suspected left-shifted cells is too large, it is determined that the neutrophils have undergone left-shifted nuclear. [0004] However, the number of suspected left-shifted cells counted by this identification method often has larg...

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Problems solved by technology

[0004] However, the number of suspected left-shifted cells counted by this identification method often has large differences in the identification results of nuclear left-shifted cells due to factors such as instrument differences and instrument debugging accuracy.

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