A kind of active oxygen mimic enzyme nanomaterial with thorn structure and its preparation method and application

A technology of nanomaterials and oxymimitase, which is applied in medical preparations of non-active ingredients, active ingredients of artificially synthesized polymeric materials, pharmaceutical formulations, etc., to achieve the effect of improving catalytic activity, strong broad-spectrum pathogen capture and ablation ability
CN111840252BActive Publication Date: 2021-05-25WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-05-25

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Abstract

The invention provides a nano-material with a thorn-like structure for producing active oxygen imitating enzyme, its preparation method and application, and belongs to the field of biomedical materials. The nanomaterial is prepared from raw materials in the following proportions: 1 to 10 parts by weight of POD-M, 1 to 10 parts by weight of cetyltrimethylammonium bromide, 0.001 to 0.1 parts by weight of alkali, and four parts by weight of orthosilicate 10-100 parts by volume of ethyl ester, 100-1000 parts by volume of cyclohexane; the POD-M is prepared from the following raw materials in the weight ratio: 1-10 parts of copper acetate monohydrate, 1-10 parts of phosphomolybdic acid, 1-10 parts of glutamic acid, 1-10 parts of trimesic acid. The V-POD-M nanosystem based on the in-situ "capture-kill" (LCK) sterilization model of the present invention has a strong broad-spectrum pathogen capture and killing ability, which not only provides a new way to improve catalytic activity for other catalytic systems strategy, and in biomedical applications such as high-efficiency anti-pathogen infection, antibacterial implant materials, and composite scaffold materials, it shows great possibilities to replace antibiotics.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a nanomaterial with a thorn-like structure for producing active oxygen imitating enzymes, a preparation method and application thereof. Background technique

[0002] Severe infectious diseases such as acute respiratory syndrome, purulent dermatosis, and mucositis afflict millions of people every year in emergencies of global epidemic outbreaks. At present, due to the lack of specific drugs and treatment options, it is of great significance to develop new treatment strategies for infections caused by bacteria and pathogenic microorganisms. Nature has created an efficient model for bactericidal activity, the antibacterial process of bacteriophages. Phages are viruses with unique spines that enable targeted bacterial capture. Subsequently, the nucleic acid of the phage, acting as a bactericidal substance, can be released and enter the bacteria to induce its ablation...

Claims

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