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A kind of cosmetic plastic injection material and its injection method

A technology of water for injection and L-polylactic acid, applied in the field of biomedical engineering, can solve the problems of waste of manpower and material resources, short residence time, multiple injections, etc., and achieve the effect of saving materials and costs, strong hydrophilicity, and avoiding injections

Active Publication Date: 2021-10-01
珠海医美企业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, a single levorotatory polymer has a high degree of crystallinity and poor hydrophilicity, and is a brittle material; usually after injection, manual or specific mechanical equipment is required for regular massage to prevent the formation of nodules and other problems. The operation proficiency or the precision of mechanical equipment is high, which greatly wastes the cost of manpower and material resources
In addition, in the prior art, the injection of poly-L-lactic acid is usually a direct injection. Due to the degradation of poly-L-lactic acid and its characteristics of being easily absorbed by human skin, the residence time of directly injected poly-L-lactic acid in the skin is very short and cannot maximize the To exert the effect of L-polylactic acid, multiple injections are required, which wastes materials and is cumbersome to operate

Method used

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  • A kind of cosmetic plastic injection material and its injection method
  • A kind of cosmetic plastic injection material and its injection method
  • A kind of cosmetic plastic injection material and its injection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A modified L-lactic acid plastic material, characterized in that: The modified L-lactic acid plastic material is first obtained by the copolymerization reaction of poly 2-hydroxysuccinic acid and L-polylactic acid, and then modified Mix L-lactic acid with sodium hyaluronate and mannitol to get it.

[0038] The preparation steps of modified L-polylactic acid are specifically:

[0039] a, the synthesis of poly 2-hydroxysuccinic acid:

[0040] a 1 , under nitrogen protection atmosphere, at first in reactor, add the 2-hydroxysuccinic acid of 40 weight parts, and add the diisopropyl titanate of chelation type two (acetylacetonate group) as catalyst, catalyst bis(acetylacetonate) Base) diisopropyl titanate consumption is 0.1% of the moles of 2-hydroxysuccinic acid;

[0041] a 2 , Then the temperature in the reactor is raised to 110°C, and the esterification and polycondensation reaction is carried out at a stirring speed of 80r / min under normal pressure, and the reaction ...

Embodiment 2

[0058] A modified L-lactic acid plastic material, characterized in that: The modified L-lactic acid plastic material is first obtained by the copolymerization reaction of poly 2-hydroxysuccinic acid and L-polylactic acid, and then modified Mix L-lactic acid with sodium hyaluronate and mannitol to get it.

[0059] The preparation steps of modified L-polylactic acid are specifically:

[0060] a, the synthesis of poly 2-hydroxysuccinic acid:

[0061] a 1 , under the nitrogen protection atmosphere, at first in the reactor, add the 2-hydroxysuccinic acid of 45 weight parts, and add the diisopropyl titanate of chelation type two (acetylacetonate group) titanate as catalyst, catalyst bis(acetylacetonate) Base) diisopropyl titanate consumption is 0.12% of the moles of 2-hydroxysuccinic acid;

[0062] a 2 , Then the temperature in the reactor was raised to 118°C, and the esterification and polycondensation reaction was carried out at a stirring speed of 100r / min under normal pressu...

Embodiment 3

[0079] A modified L-lactic acid plastic material, characterized in that it is composed of a modified L-lactic acid plastic material. The modified L-lactic acid is mixed with the modified L-lactic acid, sodium hyaluronate and mannitol.

[0080] The preparation steps of modified L-polylactic acid are specifically:

[0081]a, the synthesis of poly 2-hydroxysuccinic acid:

[0082] a 1 , under nitrogen protection atmosphere, at first in reactor, add the 2-hydroxysuccinic acid of 50 weight parts, and add the diisopropyl titanate of chelation type two (acetylacetonate group) as catalyst, catalyst bis(acetylacetonate) Base) diisopropyl titanate consumption is 0.15% of the moles of 2-hydroxysuccinic acid;

[0083] a 2 , Then, the temperature in the reactor was raised to 125°C, and the esterification and polycondensation reaction was carried out at a stirring speed of 120r / min under normal pressure, and the reaction time was 5h;

[0084] a 3 , when the temperature at the top of th...

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Abstract

The invention provides a modified L-polylactic acid plastic material, a cosmetic plastic injection material and an injection method thereof. The modified L-lactic acid is obtained through a copolymerization reaction of poly 2-hydroxysuccinic acid and L-polylactic acid, and then Modified poly-L-lactic acid plastic material is obtained by mixing modified poly-L-lactic acid with sodium hyaluronate and mannitol; this material has strong hydrophilicity, low crystallinity and strong flexibility, and can avoid the formation of nodules after injection , redness and other problems; At the same time, the coaxial double-layer injection method is used to perform the A solution mixed with milk protein cellulose and viscose cellulose and the B solution made of modified L-lactic acid plastic material on the basis of different speeds at the same time. The injection of the filler solution forms a double-layer structure to achieve sustained release, which prevents the rapid absorption of L-lactic acid by the skin, ensures that the skin can fully and completely utilize L-lactic acid, and greatly reduces costs and saves materials. use.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to an injection material for cosmetic plastic surgery and an injection method thereof. Background technique [0002] Polylactic acid is a polymer obtained by polymerization of lactic acid as the main raw material. The raw material source is sufficient and can be regenerated; the production process of polylactic acid is pollution-free, and the product can be biodegraded to realize the cycle in nature, so it is an ideal green polymer material . Due to the complete degradability of polylactic acid, it is widely used in medical, packaging and other fields, and has been certified by the US FDA as a biomedical material that can be used in the human body. Due to its high safety to the human body and excellent physical and mechanical properties, polylactic acid is widely used in the field of biomedicine, such as disposable infusion tools, non-removable surgical sutures, dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/40A61L27/20A61L27/22
CPCA61L27/18A61L27/20A61L27/227A61L27/50A61L2400/06C08L67/04C08L1/24C08L89/00
Inventor 王帅王慧敏刘小雄肖正芳
Owner 珠海医美企业管理有限公司