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Medicine for treating neuropathic pain and application of medicine

A nerve injury and drug technology, applied in the field of biomedicine

Pending Publication Date: 2020-11-27
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, there are still relatively few effective therapeutic drugs for neuropathic pain. Therefore, it is very meaningful to develop a new type of drug that can effectively treat neuropathic pain.

Method used

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  • Medicine for treating neuropathic pain and application of medicine
  • Medicine for treating neuropathic pain and application of medicine
  • Medicine for treating neuropathic pain and application of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This example explores that exogenous β-amyloid 1-42 (Aβ1-42) has the effect of significantly reducing nerve injury pain, including the following:

[0037] (1) Experimental grouping: SD rats were randomly divided into three groups, each with 8 rats, respectively:

[0038] (1.1) CCI group (Chronic constriction injury of the sciatic nerve, chronic contraction injury group of sciatic nerve), the rats in this group received sciatic nerve ligation, the specific method was: cut a 50mm hole in the middle of the left thigh of the rat An opening was made to expose the left common sciatic nerve. The proximal bifurcation of the sciatic nerve was peeled off the adhesion tissue, and four ligatures (4-0 surgical catgut) were used to loosely make four ligatures on the total sciatic nerve at an interval of about 1 mm to cause contraction damage of the sciatic nerve, and pass through the sheath Inject 10 μL of normal saline, as the nerve injury group;

[0039](1.2) CCI+Aβ1-42 group (ch...

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PUM

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Abstract

The invention relates to a medicine for treating neuropathic pain and application of the medicine. The medicine comprises beta amyloid protein 1-42. The invention creatively discovers that expressionof endogenous A beta 1-42 in a neuropathic damage model is increased, and the purpose of treating neuropathic pain can be achieved by intrathecally injecting exogenous A beta 1-42; activated glial cells participate in occurrence and maintenance of neuropathic pain, and the exogenous A beta 1-42 can be injected to remarkably inhibit activation of astrocytes and microglial cells caused by neuropathic damage, so that the effect of easing pain in early or late stages of pain is achieved, and the medicine is a potential targeted medicine for treating neuropathic pain. The invention provides a theoretical basis for researching a treatment strategy of the neuropathic pain, and provides an insertion site for preparing a new medicine for treating the neuropathic pain.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a new application of amyloid beta 1-42, in particular to the application of amyloid beta 1-42 in the preparation of medicine for treating nerve injury pain. Background technique [0002] Neuropathic pain is a chronic disease caused by peripheral or central nervous system injury, characterized by hyperalgesia or spontaneous pain, which seriously affects the quality of life of patients. Chronic neuropathic pain is often difficult to treat. Although there are many treatment methods, the curative effect is often uncertain, including drug therapy, neuromodulation, nerve block, nerve pulse radiofrequency, nerve damage, etc. For the vast majority of patients, drug therapy is the most basic and most commonly used method. Traditional analgesics such as morphine, tramadol, and acetaminophen are only sensitive to some patients, and the therapeutic effect is not satisfactory....

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P25/00A61P25/02A61P29/00
CPCA61K38/1716A61P25/00A61P25/02A61P29/00Y02A50/30
Inventor 宋学军
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA