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Cell fermentation tank device for herpes zoster vaccine production

A technology for vaccine production and cell fermentation, which can be used in bioreactor/fermenter combinations, tissue cell/virus culture devices, bioreactors/fermenters for specific purposes, etc. , to achieve the effect of improving the effect of stirring

Inactive Publication Date: 2020-12-01
AB&B BIO TECH CO LTD JS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the production process of herpes zoster vaccine, the cells need to be fermented, and the existing fermentation equipment directly uses the motor to drive the stirring rod in the fermenter to stir to improve the sufficiency of fermentation, and then this simple However, there will still be a lot of dead angles in the stirring method, which will cause the problem of insufficient stirring. Therefore, it is necessary to design a cell fermenter device for the production of herpes zoster vaccine to solve the above problems

Method used

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  • Cell fermentation tank device for herpes zoster vaccine production
  • Cell fermentation tank device for herpes zoster vaccine production
  • Cell fermentation tank device for herpes zoster vaccine production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A cell fermenter setup for the production of herpes zoster vaccine, such as Figure 1-3 As shown, including the tank body 1, the outer walls of the four corners of the bottom of the tank body 1 are connected with support pads by bolts, the top outer wall of the tank body 1 is connected with a support top plate 5 by bolts, and the top central outer wall of the support top plate 5 is connected by bolts. Motor 8, the output shaft of the rotating motor 8 is connected with the first sleeve 9 by bolts, and the top inner wall of the first sleeve 9 is connected with the second spring 16 by bolts, and the bottom outer wall of the second spring 16 is connected with the support rod by bolts 14, and the support rod 14 is inserted into the inner wall of the first sleeve 9, and the outer walls on both sides of the support rod 14 are connected with the second sleeve 13 equidistantly arranged by bolts, and the inner walls of the second sleeve 13 are all connected by bolts. The first sp...

Embodiment 2

[0032] A cell fermenter setup for the production of herpes zoster vaccine, such as Figure 1-5 As shown, it also includes a connecting rod 17 installed on the outer wall of the bottom of the support rod 14 by bolts, and the outer walls on both sides of the bottom of the two connecting rods 17 are connected with connecting blocks 18 by bolts, and the outer walls of the bottom of the two connecting blocks 18 are connected by bolts. A roller 19 is connected, and the inner circumferential wall of the bottom of the tank body 1 is connected with an annular wave block 20 by bolts, and the corrugations of the ring wave block 20 are arranged symmetrically with the center of the ring wave block 20 .

[0033] When this embodiment is in use, during the rotation of the rotating motor 8, it will drive the support rod 14 to rotate, and then drive the connecting rod 17 and the roller 19 to rotate, so that the roller 19 rolls along the ring-shaped wave plate 20, and the center is symmetrically ...

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Abstract

The invention discloses a cell fermentation tank device for herpes zoster vaccine production, relates to the technical field of cell fermentation, and aims at solving the problem that existing cell fermentation tanks are insufficient in fermentation. The device specifically comprises a tank body, supporting pads are fixedly installed on the outer walls of the four corners of the bottom of the tankbody, a supporting top plate is fixedly installed on the outer wall of the top of the tank body, a rotating motor is fixedly installed on the outer wall of the center of the top of the supporting topplate, a first sleeve is fixedly installed on an output shaft of the rotating motor, and a second spring is fixedly installed on the inner wall of the top of the first sleeve. According to the cell fermentation tank device for herpes zoster vaccine production, liquid guide holes are formed in the arc-shaped supporting plate at equal intervals, and the section of the liquid guide holes is arrangedto be in a sandglass shape, that is, the calibers of the two ends are large and the caliber of the middle is small. In the back-and-forth moving process of the arc-shaped supporting plate, materialscan form flow speed difference inside and outside the liquid guide holes, and then the stirring effect can be further improved.

Description

technical field [0001] The invention relates to the technical field of cell fermentation, in particular to a cell fermenter device for the production of herpes zoster vaccine. Background technique [0002] Fermentation refers to the process in which people use the life activities of microorganisms under aerobic or anaerobic conditions to prepare the microbial cells themselves, or direct metabolites or secondary metabolites. Fermentation is sometimes also written as ferment, and its definition varies depending on the occasion of use. The so-called fermentation usually refers to a certain decomposition process of organisms for organic matter. [0003] In the production process of herpes zoster vaccine, the cells need to be fermented, and the existing fermentation equipment directly uses the motor to drive the stirring rod in the fermenter to stir to improve the sufficiency of fermentation, and then this simple However, there will still be many dead angles in the stirring met...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/02C12R1/93
CPCC12M23/22C12M23/38C12M23/48C12M27/02C12M27/22
Inventor 张宏栋杨宪普安蕊宋庆丽游媛媛秦奇
Owner AB&B BIO TECH CO LTD JS