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Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis

A technology of ointment and traditional Chinese medicine, which is applied in the directions of ointment delivery, pharmaceutical formulations, medical preparations of inactive ingredients, etc., can solve the problems of no discovery of antifungal and therapeutic effects on tinea pedis, and achieves remarkable curative effect, convenient use and portability, good stability

Inactive Publication Date: 2020-12-15
武汉润禾生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Literature reports did not find its antifungal and treatment of tinea pedis

Method used

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  • Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis
  • Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis
  • Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The curative effect difference of Chinese medicine ointment prepared by the present invention and other reference substances to tinea pedis:

[0041] DUT:

[0042] A Chinese medicinal ointment for the treatment of tinea pedis, prepared by the following method:

[0043] The main active ingredients of the traditional Chinese medicine ointment are proportioned by weight: Andrographis paniculata (Burm.f.) Nees 10.0, Rose chinensis Jacq. 5.0, Phellodendronchinense Schneid. 5.0.

[0044] Step 1: Remove impurities and dust from Andrographis paniculata, Chinese rose and Phellodendron phellodendron in the above ratio, and then add them to the traditional Chinese medicine extraction tank;

[0045] Step 2: Add 70% ethanol with 5 times the weight of medicinal materials into the extraction tank, stir and mix;

[0046] Step 3: Heat up the extraction tank to 90°C, reflux extraction for 5 hours, filter, and collect the extract into the concentration tank;

[0047] Step 4: Add 70% et...

Embodiment 2

[0086] A Chinese medicinal ointment for the treatment of tinea pedis, prepared by the following method:

[0087] The main active ingredients of the traditional Chinese medicine ointment are proportioned by weight: Andrographis paniculata (Burm.f.) Nees 8.0, Rosa chinensis Jacq. 3.0, Phellodendron chinense Schneid. 3.0.

[0088] The preparation steps and parameters are the same as the preparation steps of the sample to be tested in Example 1, and the use method is the same as in Example 1.

[0089] Test results: The changes of tinea pedis after 14 days of use by 20 people are shown in the table below:

[0090]

[0091]

[0092] Example 2 Use the reference substance 4 groups of volunteers with a total of 20 people, with an age distribution of 15 to 44 years old. According to the weight calculation of 25% for each index, the total effective rate is 100%, and there is no recurrence 15 days after discontinuation.

Embodiment 3

[0094] A Chinese medicinal ointment for the treatment of tinea pedis, prepared by the following method:

[0095] The main active ingredients of the traditional Chinese medicine ointment are proportioned by weight: Andrographis paniculata (Burm.f.) Nees 9.0, Rosa chinensis Jacq. 4.0, Phellodendron chinense Schneid. 4.0.

[0096] The preparation steps and parameters are the same as the preparation steps of the sample to be tested in Example 1, and the use method is the same as in Example 1.

[0097] Test results: The changes of athlete's foot after 7 days of use by 20 people are shown in the table below:

[0098]

[0099]

[0100] Example 3 A total of 20 volunteers using the product of the present invention, aged 16 to 44 years old, calculated according to the weight of 25% for each index, the total effective rate is 100%, and there is no recurrence 15 days after discontinuation.

[0101] The results of Example 2 and Example 3 show that adjusting the ratio of medicinal ma...

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Abstract

The invention belongs to the field of medicines, and particularly relates to a preparation method and application of traditional Chinese medicine ointment for treating tinea pedis. Three traditional Chinese medicine ointment comprises herba andrographitis, flos rosae chinensis and cortex phellodendri which are combined, and an optimal medicinal material proportion is selected to play a synergisticeffect; effective components of traditional Chinese medicinal materials in a prescription can be extracted by using 65%-70% ethanol for extraction, the extract taking the 65-70% ethanol as a solventis subjected to vacuum concentration to prepare an extract, on the basis, the extract and other auxiliary materials are prepared into ointment by using a traditional process, and the prepared ointmentis high in stability, high in effective concentration of medicines and definite in curative effect on tinea pedis.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a preparation method and application of a traditional Chinese medicine ointment for treating tinea pedis Background technique [0002] Tinea pedis is the most common skin fungal disease in dermatology, and belongs to the category of "foot dampness" in traditional Chinese medicine. Doctor trained in Western medicine thinks that tinea pedis is mainly caused by infections such as Trichophyton rubrum, Trichophyton mentagrophytes, and it is often a mixed infection of two or more bacteria clinically. [0003] Traditional Chinese medicine believes that the disease is caused by inadvertent daily life, spleen and stomach dampness and heat, and dampness and heat evil invades outside, stagnant in the skin and hair, over time, qi and blood stagnation, blood septic muscle rot, windworm breeding, so itching endlessly, tinea pedis Clinically, it is mainly divided into hyperkeratotic type, ...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/06A61K47/18A61P17/00A61P31/10
CPCA61K36/19A61K36/738A61K36/756A61K9/06A61K47/18A61P17/00A61P31/10A61K2300/00
Inventor 王线周清郑和国
Owner 武汉润禾生物医药有限公司
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