Primer set and kit for detecting polymorphism of hyperglycemia drug metabolism related genes and application of primer set and kit

A technology of gene polymorphism and polymorphism, which is applied in the fields of medicine and biology, can solve problems such as aggravating adverse reactions and inability to effectively lower blood sugar, and achieves the advantages of reducing adverse drug reactions, high sensitivity and specificity, and simple sample processing Effect
CN112210598APending Publication Date: 2021-01-12PRECEDO PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PRECEDO PHARMA CO LTD
Publication Date
2021-01-12

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Abstract

The invention relates to the technical field of medicine and biology, and discloses a primer set and a kit for detecting polymorphism of hyperglycemia drug metabolism related genes and application ofthe primer set and the kit. The primer set comprises primers capable of amplifying at least one hyperglycemia drug metabolism related gene: CYP2C9, KCNJ11, PPARgamma, SLCO1B1, SLC22A1, SLC22A2, and APOE. The primer set can also comprise a sequencing primer for carrying out Sanger sequencing on at least one of the above genes. The primer set and kit can formulate different schemes for hyperglycemiapatients according to individual differences of genes, select appropriate hypoglycemic drugs, realize accurate typing and precise medication, thereby increase hypoglycemic effect and reduce adverse drug reactions. The preferred primer set has high sensitivity and specificity, and when the preferred primer set is used for genotyping genes related to hyperglycemia drug metabolism, the primer set has advantages of being accurate in qualitative analysis, high in specificity and the like.
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Description

technical field

[0001] The invention relates to the fields of medicine and biotechnology, in particular to a primer set and a kit for detecting hyperglycemic drug metabolism-related gene polymorphisms and applications thereof. Background technique

[0002] China is the country with the largest number of diabetic patients in the world. According to the latest diabetes map released by the International Diabetes Federation (IDF) in 2017, the number of diabetics in China has reached 114 million, ranking first in the world, and type 2 diabetes accounts for more than 90% of diabetic patients. Diabetes is a metabolic disease characterized by hyperglycemia in the blood. Hyperglycemia is due to defective insulin secretion or impaired biological function. If the human body has high blood sugar for a long time, it will lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves.

[0003] There are two main reasons for diabe...

Claims

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