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Apparatus and method for in-vivo measurement of corneal biomechanical response

A cornea and device technology, applied in the field of measuring the biomechanical response of the human cornea in vivo, can solve the problem of not providing information on the surface shape, etc.

Pending Publication Date: 2021-01-15
CYLITE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Spectral domain OCT has been used to measure tear film thickness, see for example dos Santos et al'In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography', Optics Express 23(16), 21043(2015), but not Provides information about the shape of the surface

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  • Apparatus and method for in-vivo measurement of corneal biomechanical response

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Embodiment Construction

[0090] Figure 1A A spectral domain optical coherence tomography (OCT) device suitable for in vivo measurements of one or more properties of the cornea 102 at multiple points with phase accuracy, ie nanoscale accuracy, is shown in schematic form according to an embodiment of the present invention 100. Light 104 from a broadband light source 106 , such as a superluminescent diode with a center wavelength of 840 nm and a bandwidth of 40 nm, is collimated by a collimating element 108 such as a lens or parabolic mirror, linearly polarized by a polarizer 110 , and subsequently polarized by a polarizing beam splitter cube (PBS) 112 Divided into reference beams and sample beams 114 , 116 . The reference arm 117 includes a mirror 118, a movable shutter 120 for blocking the reference beam 114 when the device is operating without the reference beam, and a quarter wave plate 122 for polarization conversion so that light reflected from the mirror 118 passes through PBS 112 and into the d...

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Abstract

Apparatus and methods are presented for non-contact in-vivo measurement of one or more properties of a cornea or tear film with spatial resolution. In certain embodiments the cornea / tear film is probed at substantially normal incidence with a converging array of beamlets from a multi -wavelength optical source, and the reflected light analysed interferometrically to generate a time sequence of pachymetry maps. Thickness variations arising from differences between the external and intraocular pressure, e.g. from the ocular pulse or externally applied pressure changes, are measured and analysedto obtain information on a biomechanical response of the cornea. In preferred embodiments the time variation in tear film thickness is measured and subtracted to yield normalised pachymetry data for the biomechanical analysis. In certain embodiments the apparatus is configured to measure the dynamics and profile of the tear film, using either converging or substantially parallel arrays of beamlets.

Description

technical field [0001] The present invention relates to apparatus and methods for optical metrology, in particular for in vivo measurement of the biomechanical response of the human cornea. It should be understood, however, that the present invention is not limited to this particular field of use. [0002] Related applications [0003] This application claims priority to Australian Provisional Patent Application No. 2018902018 filed on June 5, 2018, the contents of which are incorporated herein by reference. Background technique [0004] Any discussion of the prior art throughout the specification should in no way be taken as an admission that such prior art is well known or forms part of the common general knowledge in the field. [0005] Keratoconus is a degenerative disease in which localized thinning and reduced stiffness lead to deformation of the cornea, which directly impairs the quality of vision. Although the corneal deformation characteristic of more advanced ke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/10
CPCA61B3/0025A61B3/1005A61B3/101A61B3/102A61B3/107A61B3/165A61B3/0008A61B3/16
Inventor 史蒂文·詹姆斯·弗里斯肯格兰特·安德鲁·弗里斯肯特雷弗·布鲁斯·安德森
Owner CYLITE