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Artificial multiporous nanometer cornea made of carbon-polyvinyl alcohol hydrogel

A polyvinyl alcohol and artificial cornea technology, applied in medical science, eye implants, prostheses, etc., can solve problems such as poor visual effects, and achieve the effects of easy processing, good elasticity, and convenient operation

Inactive Publication Date: 2005-01-26
深圳华明生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor visual results obtained after surgery

Method used

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  • Artificial multiporous nanometer cornea made of carbon-polyvinyl alcohol hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] made with figure 1 The artificial cornea of ​​the shape shown: The material of the supporting part of the artificial cornea is porous nano-carbon. The optical part material is polyvinyl alcohol hydrogel. The artificial cornea is molded at one time by the two materials combined with the stamping and casting method. The diameter of the optical part is 0.6-10.0mm, the thickness is 200-400μm, the diameter of the optical center is 2-5mm, and the width of the skirt is 2.0-3.0mm. The connection between the optical part and the peripheral support part is plastically formed into a stepped right-angle structure, the support part enters the optical part by 0.5-1.5 mm, and the upper and lower surfaces of the optical part protrude from the peripheral support part by 100-150 μm.

Embodiment 2

[0018] A specific example of implanting the artificial cornea into the New Zealand rabbit cornea: After the porous nano-carbon-polyvinyl alcohol hydrogel artificial cornea is modified, the wet disinfection method is used. The specific steps are as follows: 1. Soak the artificial cornea in 10% NaOH 2. Under sterile conditions, move the artificial cornea to a non-polluting 0.1% NaOH solution for storage; 3. 20 minutes before implanting the artificial cornea, move the artificial cornea to Sterilized non-polluting 0.5% NaHCO 3 In the solution, shake gently for 10 minutes to neutralize NaOH; 4. Move the artificial cornea to a balanced salt solution and rinse it 6 times for later use. The artificial cornea was implanted between the corneal layers of New Zealand rabbits. One month after the operation, most of the new blood vessels grew into the center of the cornea, and lasted until two months after the operation. The growth of new blood vessels reached the peak at three months. In ...

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Abstract

A porous nanometer carbon-polyvinyl alcohol hydrogel artificial cornea, which is used for patients of cornea diaphaneity descent and cornea blind caused by eye tissue diseases, consisting of an optical part and a supporting part, the optical part being made from transparent polyvinyl alcohol hydrogel, and the supporting part being made from black nanometer carbon materials. The optical part is provided with an upper and a lower surface, the supporting part enwraps the optical part, combines tightly with human cornea tissues, and is embedded in the optical part. The materials of the optical part protrude on the top and the bottom and overtops the supporting part at the joint of the two parts, and forms a trapezoid right-angle structure. The invention overcomes the shortcomings of existing techniques, and is capable of watertightness engomphosis with host cornea, preventing infection, degrowth of corneal epitheliums, antagonizing intra-ocular pressure, and preventing the forming of the back fibrous membrane of cornea. The artificial cornea has advantages of tenderness, good elasticity, certain tensile strength, convenience in surgical operation, and maximum decrease of complicating diseases.

Description

technical field [0001] The present invention relates to artificial corneas. Porous nano-carbon-polyvinyl alcohol hydrogel artificial cornea is used for patients with decreased corneal transparency caused by eye tissue diseases and corneal blindness. It replaces the damaged cornea and restores the visual function of the artificial cornea. Background technique [0002] An artificial cornea generally consists of an optical part and a supporting part. [0003] Japanese Patent Publication No. 158859 patent in 1992, the disclosed artificial cornea patent: the support part uses the artificial cornea with micro-gap structure material, the optical part is made of transparent plastic that can transmit visible light, and the support part is made of soft porous fluorine Made of resin. The supporting part of this artificial cornea is only made of soft porous fluororesin with a fine gap structure, so the problems of outflow of aqueous humor and invasion of bacteria in the eye cannot be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14A61L27/00
Inventor 姚晓明邓宏伟
Owner 深圳华明生物科技有限公司
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