Application of sinomenine compound to preparation of medicines for preventing or treating glioma

A glioma and compound technology, applied in the field of medicine, can solve problems such as no reports of sinomenine esters against glioma

Active Publication Date: 2021-01-29
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been related studies on the anti-tumor effect of sinomenine, but there is no report on the anti-glioma effect of sinomenine esters

Method used

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  • Application of sinomenine compound to preparation of medicines for preventing or treating glioma
  • Application of sinomenine compound to preparation of medicines for preventing or treating glioma
  • Application of sinomenine compound to preparation of medicines for preventing or treating glioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Dilute sinomenine ester sino-wcj-33 with DMEM high-glucose medium containing 10% fetal bovine serum to the concentration in Table 1, and treat U87 cells with different concentrations of sinomenine ester sino-wcj-33 for 24 hours , cell viability after 48 and 72 hours see figure 1 and Table 1.

[0043] Table 1. The cell inhibition rate of sinomenine ester sino-wcj-33 acting on U87 for different time at different dosages

[0044]

[0045] It can be seen that sinomenine ester sino-wcj-33 inhibits the proliferation of glioma U87 in a concentration- and time-dependent manner, and the half inhibitory rate (IC 50 ) is about 7.43 μM.

[0046] Dilute sinomenine ester sino-wcj-33 with DMEM high-glucose medium containing 10% fetal bovine serum to 0, 4, 8, and 12 μM, and use 0, 4, 8, and 12 μM sinomenine ester sino-wcj respectively -33 acted on U87 cells, and the changes in cell morphology were detected after 24 hours and 48 hours, and the results were as follows figure ...

Embodiment 2

[0053] (1) Dilute sinomenine ester sino-wcj-33 with DMEM high-glucose medium containing 10% fetal bovine serum to the concentration in Table 1, and act on U251 cells with different concentrations of sinomenine ester sino-wcj-33 for 24 hours , cell viability after 48 and 72 hours see Figure 8 and Table 2.

[0054] Table 2. The cell inhibition rate of sinomenine ester sino-wcj-33 acting on U251 for different time at different dosages

[0055]

[0056] It can be seen that sinomenine ester sino-wcj-33 inhibits the proliferation of glioma U251 in a concentration- and time-dependent manner, and the half inhibitory rate (IC 50 ) is about 8.76 μM.

[0057] Dilute sinomenine ester sino-wcj-33 with DMEM high-glucose medium containing 10% fetal bovine serum to 0, 4, 8, and 12 μM, and use 0, 4, 8, and 12 μM sinomenine ester sino-wcj respectively -33 acted on U251 cells, and the changes in cell morphology were detected after 24 hours and 48 hours, and the results were as follows F...

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Abstract

The invention relates to application of a sinomenine compound in preparation of a medicine for preventing or treating glioma. The sinomenine compound is sino-wcj-33. The sino-wcj-33 disclosed by the invention can be used for inhibiting the proliferation of glioma cells. The sino-wcj-33 disclosed by the invention realizes an anti-tumor effect by inducing cell apoptosis. The sino-wcj-33 provided bythe invention inhibits tumor by inhibiting migration and invasion of glioma cells. The sino-wcj-33 provided by the invention blocks the cell cycle tissue in a G0 / G1 phase.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an antitumor drug, in particular to the application of sinomenine compounds in the preparation of drugs for preventing or treating glioma. Background technique [0002] Glioma is a tumor derived from neuroepithelium, accounting for 40%-50% of brain tumors, and is the most common intracranial malignant tumor. Glioma is the malignant tumor with the highest morbidity, recurrence rate and mortality rate, and the median survival period of glioblastoma, which accounts for more than 50% of the incidence of malignant glioma, is only 10-12 months. At present, temozolomide is the first-line drug for the clinical treatment of glioma, but because glioma cells are prone to drug resistance to it, its clinical effective rate is less than 45%. Therefore, it is very important to find effective drugs for the treatment of glioma. [0003] The traditional Chinese medicine Qingfengteng is the dry can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P35/00
CPCA61K31/4748A61P35/00
Inventor 王金华吉腾飞杜冠华郑湘锦李婉任利文刘金宜
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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