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Application of astaxanthin ester in hair growth promoting products

An astaxanthin ester, hair growth technology, applied in the application, the function of food ingredients, medical preparations containing active ingredients, etc., can solve the problems of low activity of astaxanthin, low bioavailability, narrow adaptability, etc., To achieve the effect of good and easy transdermal absorption, simple steps and high bioavailability

Inactive Publication Date: 2021-02-02
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is that there are many defects in the current treatment methods for hair loss, such as narrow adaptability, high price and side effects; and it may be of great significance to explore a new way of hair loss treatment in the direction of diet, wherein astaxanthin is because of its Physiological activities such as scavenging free radicals, anti-cancer, anti-inflammation, and anti-aging are favored by more and more researchers, but astaxanthin has low activity in the body, less absorption in the body, rapid metabolism, and low bioavailability. Limiting its further clinical application

Method used

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  • Application of astaxanthin ester in hair growth promoting products
  • Application of astaxanthin ester in hair growth promoting products
  • Application of astaxanthin ester in hair growth promoting products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of astaxanthin ester rich in DHA / EPA

[0033] 1) Measure 1.5 mL of free DHA / EPA, weigh 500 mg of free astaxanthin, 1600 mg of catalyst EDCL and 400 mg of DMAP and place them in a brown vial. Add 5mL of dichloromethane, fill with nitrogen and mix well after sealing. Placed in a shaking incubator at 25°C for 10 h. Synthesis of astaxanthin diester was confirmed by TLC plates.

[0034] 2) Measure 0.6 mL of free DHA / EPA, weigh 500 mg of free astaxanthin, 400 mg of catalyst EDCL and 200 mg of DMAP and place them in a brown vial. Add 5mL of dichloromethane, fill with nitrogen and mix well after sealing. Place in a shaking incubator at 25°C for 1 h. Synthesis of astaxanthin monoesters was confirmed by TLC plates.

[0035] 3) After fully dissolving the prepared DHA / EPA monoester / diester with 100mL of dichloromethane, place it in a separatory funnel. First, add 100mL of 1mol / L hydrochloric acid solution, mix well and let it stand for stratifica...

Embodiment 2

[0038] Embodiment 2: animal experiments

[0039] 2.1. Materials and methods

[0040] (1) Animal feeding and behavioral analysis

[0041] As experimental animals, male KM mice weighing 20-22 g were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The humidity in the animal room is 65±15%, the room temperature is 23±2°C, and the light and dark alternate between 12h:12h. The mice can eat and drink freely. After one week of adaptive feeding, 64 male KM mice were divided into normal group, model control group, DHA / EPA group, AST group, DHA / EPA monoester group, DHA / EPA diester group, Astaxanthin+DHA / EPA group (1:1), astaxanthin+DHA / EPA group (1:2). The feed was modified with reference to the AIN-93G rodent feed formula, and the food intake was recorded and counted. Immediately, the back hair of all the mice was removed by chemical hair removal, and 6% sodium sulfide alcohol solution was prepared, and the depilatory agent was dipped in absorbent cotto...

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Abstract

The invention belongs to the technical field of astaxanthin ester preparation, and particularly relates to application of astaxanthin ester in hair growth promoting products. Experimental research proves that astaxanthin and astaxanthin ester have the effect of promoting hair growth and also have the effect of relieving alopecia, so that a new application is added to the astaxanthin and astaxanthin ester, the astaxanthin and astaxanthin ester have industrial utilization value, and the result can be applied to medical clinical practice for promoting hair growth, is used for developing hair growing medicines and cosmetics, has potential economic and social benefits, and meets the requirements of people for anti-hair-loss products.

Description

Technical field: [0001] The invention belongs to the technical field of astaxanthin ester preparation, and in particular relates to the application of astaxanthin ester in hair growth promoting products. Background technique: [0002] Astaxanthin is a non-provitamin A oxygen-containing carotenoid with the chemical name 3,3'-dihydroxy-4,4'-diketo-β,β'-carotene, composed of a conjugated poly The molecular structure of astaxanthin contains β-ionone ring and polyunsaturated conjugated double bonds, which make it have a strong ability to quench singlet oxygen. Super strong scavenger. Studies have shown that the antioxidant activity of astaxanthin is dozens of times that of other types or carotene, and more than a hundred times that of vitamin E. A large number of animal experiments have proved that astaxanthin has physiological functions such as anti-aging, anti-inflammation, reducing oxidative damage, and enhancing body immunity. It can prevent and improve some chronic disease...

Claims

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Application Information

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IPC IPC(8): A61K31/232A61P17/14C07C403/24A23L33/12
CPCA23V2002/00A61K31/232A23L33/12A61P17/14C07C403/24C07C2601/16A23V2200/318
Inventor 王玉明史豪豪张恬恬薛长湖薛勇李兆杰徐杰王静凤常耀光唐庆娟毛相朝姜晓明丛培旭
Owner OCEAN UNIV OF CHINA
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