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Use of msc as a diagnostic, prognostic and/or therapeutic marker for cervical cancer

A cervical squamous cell carcinoma and reagent technology, applied in the field of cervical cancer diagnostic markers, can solve the problems of high probability of missed diagnosis, artificial influence of cytology detection, excessive treatment, etc., and achieve a good specific effect

Active Publication Date: 2022-07-05
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the main method of clinical cervical cancer screening is cervical liquid-based cytology combined with HPV virus detection, but the cytology detection is greatly influenced by human beings, the probability of missed diagnosis is high, the specificity of HPV detection is low, and there is overtreatment limitations

Method used

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  • Use of msc as a diagnostic, prognostic and/or therapeutic marker for cervical cancer
  • Use of msc as a diagnostic, prognostic and/or therapeutic marker for cervical cancer
  • Use of msc as a diagnostic, prognostic and/or therapeutic marker for cervical cancer

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Experimental program
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Embodiment 1

[0054] 1. MSC-related information screened by genome-wide methylation microarray

[0055] 10 cases of normal cervical tissue, CIN3 tissue and cervical cancer tissue were collected to ensure that the content of epithelial cells (normal cervix) or neoplastic cells (CIN3 or cervical cancer) in the slices was more than 30% ( figure 1 ), using the Illumina Infinium MethylationEPIC Bead Chip genome-wide methylation chip to screen 850k methylation sites, according to the method reported by Comprehensive analysis of DNA methylation data with RnBeads (Nat Methods. 2014), differential DNA methylation sites Click Filter.

[0056] 2. Validation in cervical normal epithelium-precancerous lesions-cancer patients

[0057] 1. QMSP verification

[0058] Paraffin specimens of normal cervical-precancerous lesions-cancer patients were collected in the Department of Obstetrics and Gynecology of Qilu Hospital, including 36 cases of normal cervical tissue, 36 cases of CIN and 85 cases of cervical ...

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Abstract

The present invention specifically relates to the use of MSCs as markers for diagnosis, prognosis and / or treatment of cervical cancer. Cervical cancer is a major threat to women's health. At present, the early screening method of cervical cancer is mainly HPV virus detection, but the error of cytological detection is obvious, and DNA methylation detection has gradually become a new diagnostic method for cervical precancerous lesions. The research results of the present invention show that MSC methylation is significantly different between patients with cervical precancerous lesions and healthy people, can be used as a marker for early screening of cervical cancer, and provides MSC as a diagnostic, prognostic and / or therapeutic marker for cervical cancer The application of these drugs is of great significance for the early detection of cervical cancer and the reduction of the fatality rate.

Description

technical field [0001] The invention belongs to the technical field of cervical cancer diagnostic markers, and particularly relates to the application of MSCs as cervical cancer diagnostic, prognostic and / or therapeutic markers. Background technique [0002] The information disclosed in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] Cervical cancer is the fourth most common cancer in women and the fourth leading cause of cancer-related death in women. According to the latest global data released by the International Agency for Research on Cancer, there were 569,847 new cases of cervical cancer and 311,365 deaths from cervical cancer worldwide in 2018. Although HPV vaccination and early cervical cancer screening have become eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12Q1/6858A61K45/00A61P35/00
CPCC12Q1/6886C12Q1/6858A61K45/00A61P35/00C12Q2600/154C12Q2600/118C12Q2600/112C12Q2600/158C12Q2600/166C12Q2600/136C12Q2531/113C12Q2545/101
Inventor 焦薪霖张青崔保霞孔北华
Owner SHANDONG UNIV QILU HOSPITAL