Self-adhesive hemostatic artificial dura mater repair patch and preparation method thereof

Abstract

The invention relates to the technical field of materials for neurosurgery, in particular to a self-adhesive hemostatic artificial dura mater repair patch and a preparation method thereof. The repairpatch comprises an artificial dura mater substrate which is a porous sponge structure substrate, the surface of the substrate is coated with an adhesive layer, and the used adhesive is chitosan and / orhyaluronic acid. The preparation method comprises the following steps: separately or proportionally mixing the chitosan and hyaluronic acid, and dissolving the obtained mixture in deionized water toprepare an aqueous solution with a certain concentration; coating the surface of the artificial dura mater substrate with the aqueous solution to form the adhesive layer with a certain thickness; andfreezing the artificial dura mater to dry the adhesive layer on the surface to form the self-adhesive hemostatic artificial dura mater repair patch. The repair patch can simplify the dura mater repairprocess in an operation, reduce the requirements for the technology of doctors, improve the water tightness of dura mater repair, has a hemostatic function, shortens the operation time, reduces the application of anesthetic drugs and the pain of patients, and reduces the corresponding medical expenses.

Description

technical field [0001] The invention relates to the technical field of neurosurgery materials, in particular to a self-adhesive hemostatic artificial dura patch and a preparation method thereof. Background technique [0002] Neurosurgery generally requires suturing and anatomical reduction of the incised dura (spinal) membrane. In the absence of dura (spinal) membrane defects, surgical sutures are generally used at present. If there is a dural (spinal) membrane defect, autologous Fascia or artificial materials for repair. Artificial dura can be divided into two types: absorbable materials and non-absorbable polymer materials. [0003] Most neurosurgical procedures require dura anatomical suture reduction. The suture repair of the dura mater requires watertight suture (that is, after suturing the dura mater, inject water with a certain pressure, requiring no water leakage at the suture), regardless of whether artificial dura mater or other repair materials are used, the tec...

AI Technical Summary

Problems solved by technology

However, most of the pressure-sensitive adhesives commonly used at present are for industrial purposes, and it is difficult to be absolutely non-toxic, harmless, and non-antigenic to the human body. Various body fluids and wounds are rich in blood, so the application of ordinary pressure-sensitive adhesives in dura mater bonding is correspondingly limited

Some artificial dura mater does not have a spongy structure and may not be sufficiently elastic

In the part of the dura mater defect, the pressure-sensitive adhesive will directly contact with the brain tissue and adhere to the brain tissue. or minor exposure, may cause brain tissue damage

[0010] Also in some special operations, such as the repair of cerebrospinal fluid leakage, resection of intracranial tumors through the transsphenoidal approach, open closure of cranial air cells or sinuses, repair of damaged venous sinuses, etc., can it be effectively repaired and closed at this time? It is related to the success of the operation, and even the life of the patient. There is a great need for a simple, convenient, self-adhesive patch material that can be applied in an environment with a lot of tissue fluid, but there is no suitable material in clinical practice.

It is often necessary to take the patient's autologous tissue as a repair material, which not only takes time and effort, but also increases the patient's damage, and because it must be used with medical adhesives at the same time, due to the poor effect of the adhesive, it also greatly increases the operating time. difficulty and danger

[0011] To sum up, the existing medical adhesives often have insufficient bonding strength, or insufficient elasticity and toughness, or insufficient safety.

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