Method for continuously preparing citrus flavonoids

A technology of citrus and flavonoids, which is applied in the field of continuous preparation of citrus flavonoids, can solve the problems of large consumption of organic solvents, non-continuous production, and large toxic and side effects, and achieve the effects of shortening extraction time, improving purity, and high degree of automation

Inactive Publication Date: 2021-02-26
哈工大机器人南昌智能制造研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: to provide a method for continuously preparing citrus flavonoids, which adopts the improved integration of the two methods of ultrasonic-assisted extraction and organic solvent extractio

Method used

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Examples

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Effect test

Embodiment 1

[0023] A method for continuously preparing citrus flavonoids, the method comprising the following steps:

[0024] 1) Pretreatment of citrus peels: Wash the fresh raw materials of citrus peels with water, dry them with hot air at a temperature of 50° C., and dry them for 24 hours. The water content of citrus peels is 8%. mesh sieve to obtain citrus peel powder, and when the raw material is dry citrus peel, directly pulverize through a 40-mesh sieve;

[0025] 2) Ultrasonic countercurrent extraction: Weigh 5kg of the citrus peel powder in step (1), mix the citrus peel powder and 75% ethanol aqueous solution in a mass-volume ratio of 1:2kg / L, and add the citrus peel powder in an amount of 100g / min , the flow rate of ethanol aqueous solution is 200ml / min, add a continuous ultrasonic extraction device, carry out continuous countercurrent ultrasonic extraction for 20min, ultrasonic power 400w, extraction temperature 30°C, and filter through a filter to obtain citrus flavonoid extract...

Embodiment 2

[0032] A method for continuously preparing citrus flavonoids, the method comprising the following steps:

[0033] 1) Pretreatment of citrus peels: Wash the fresh raw materials of citrus peels with water, dry them with hot air at a temperature of 40° C., and dry them for 24 hours. The water content of citrus peels is 5%. mesh sieve to obtain citrus peel powder, and when the raw material is dry citrus peel, directly pulverize through a 40-mesh sieve;

[0034] 2) Ultrasonic countercurrent extraction: Weigh 5kg of the citrus peel powder of step (1), mix the citrus peel powder and 80% ethanol aqueous solution at a mass volume ratio of 1:10kg / L, and add the citrus peel powder in an amount of 500g / min , the flow rate of ethanol aqueous solution is 5000ml / min, add a continuous ultrasonic extraction device, carry out continuous countercurrent ultrasonic extraction for 20min, ultrasonic power 400w, extraction temperature 30°C, filter through a filter to obtain citrus flavonoid extract a...

Embodiment 3

[0040] A method for continuously preparing citrus flavonoids, the method comprising the following steps:

[0041] 1) Pretreatment of citrus peels: Wash the fresh raw materials of citrus peels with clean water, dry them with hot air at a temperature of 60° C., and dry them for 10 hours. The water content of citrus peels is 8%. mesh sieve to obtain citrus peel powder, and when the raw material is dry citrus peel, directly pulverize through a 40-mesh sieve;

[0042] 2) Ultrasonic countercurrent extraction: Weigh 5kg of the citrus peel powder in step (1), mix the citrus peel powder and 70% ethanol aqueous solution in a mass-volume ratio of 1:4kg / L, and add the citrus peel powder in an amount of 300g / min , the flow rate of ethanol aqueous solution is 1200ml / min, the ultrasonic power is 800w, and the extraction temperature is 70°C, add a continuous ultrasonic extraction device, conduct continuous countercurrent ultrasonic extraction for 40min, and filter through a filter to obtain c...

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Abstract

The invention discloses a method for continuously preparing citrus flavonoids. The method comprises the following steps: 1) pretreatment of citrus peel pomace: cleaning, drying and crushing the citruspeel pomace; 2) ultrasonic countercurrent extraction: putting the citrus peel pomace powder into an ultrasonic extraction device, carrying out continuous countercurrent extraction with ethanol, and filtering to obtain a citrus flavonoid extracting solution and filter residues; 3) low-temperature concentration: concentrating the citrus flavonoid extracting solution in a low-temperature concentration device to obtain a citrus flavonoid crude concentrated solution, and recovering ethanol; 4) separation and purification: feeding the citrus flavonoid crude concentrated solution into a chromatographic column for separation and purification, and collecting a citrus flavonoid eluent; and (5) preparation of a finished product: firstly concentrating at low temperature to recover ethanol, and finally performing freeze-drying powder forming in a freeze dryer. The method improves the extraction rate of the citrus flavonoids, reduces the loss of effective components, reduces the consumption of organic solvents during extraction, is high in degree of automation, and can realize large-scale industrial continuous production.

Description

technical field [0001] The invention belongs to the field of natural product extraction, in particular to a method for continuously preparing citrus flavonoids. Background technique [0002] Citrus (Citrus reticulata Blanco), a plant belonging to Rutaceae, citrus pomace has high medicinal value, and citrus pomace contains pectin, thiamine, riboflavin, volatile oil, and flavonoids. The flavonoids contained in the orange peel mainly include some flavanones, flavonoids and flavonols, etc., with a content of about 1% to 6%, distributed in different parts of the orange peel. [0003] Flavonoids extracted from natural plants have anti-oxidation effects. Citrus flavonoids have the functions of lowering blood fat, enhancing immunity, anti-virus, anti-inflammation, anti-cancer activity, preventing atherosclerosis and increasing cholesterol, etc. Physiological activities such as oxidation, anti-cancer, prevention of cardiovascular disease, anti-inflammation, anti-allergy, and inhibit...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K131/00
CPCA61K36/752A61K2236/13A61K2236/15A61K2236/17A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 刘兆宇赵亮彭丽
Owner 哈工大机器人南昌智能制造研究院
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