Magnetic field drive control micromanipulation system for biological sample

Abstract

The invention relates to a magnetic field drive control micromanipulation system for a biological sample. The magnetic field generator comprises three groups of Maxwell coil assemblies and a coil fixing table for fixing the three groups of Maxwell coil assemblies, and the three groups of coil assemblies are respectively orthogonal; and the imaging system comprises an X-direction moving sliding table and a Y-direction moving sliding table, the support is arranged at the joint of the X-direction moving sliding table and the Y-direction moving sliding table, the electron microscope is arranged onthe support, the supporting table penetrates through the center of the Z-direction Maxwell coil, and the supporting table is located in the Y-direction Maxwell coil set. The electron microscope comprises a biological sample loading and operating table, the biological sample loading and operating table is arranged on the supporting table, the biological sample loading and operating table comprisesa magnetic control robot, and the magnetic control robot selects different structures according to different biological samples and different experimental tasks. According to the invention, micromanipulation can be carried out on any biological sample experiment object and any experiment task in biological research.

Description

technical field [0001] The invention relates to the technical field of micromanipulation equipment, in particular to a magnetic field-driven control micromanipulation system for biological samples. Background technique [0002] In the micromanipulation of biological samples, it is usually necessary to perform large-scale high-throughput injection, observation, and measurement of mechanical properties of tiny biological samples, and it is usually necessary to transfer the biological samples to the corresponding position and carry out these operations. Posture adjustment, fixation, etc. for injection, observation, and measurement of specific organs. In the traditional manual operation, the general operator uses a glass tube to generate negative pressure to absorb the organism, and then places it in the agar plate made according to the requirements of different biological samples to position and fix the plane biological sample posture, and finally perform various injection oper...

AI Technical Summary

Problems solved by technology

This process requires people to operate under the microscope for a long time, and has high requirements for operators. Generally, it takes more than half a year of professional training, and it often takes several minutes to operate a biological sample.

At the same time, negative pressure is used for suction and transfer. The selection of negative pressure is generally determined based on experience. It is difficult to guarantee that no damage will be caused to biological samples. In addition, it often takes one to two days to make an additional set in order to perform plane posture positioning and fixation. Dedicated agar plate

[0003] In order to solve the above problems, researchers at home and abroad have proposed a variety of solutions. The most common method is to use microfluidic chips for biological sample transmission and attitude adjustment, etc., but it requires special flow channels for different biological samples. And once designed, it can only be aimed at specific tasks, and cannot flexibly adapt to changes in tasks

Images