Check patentability & draft patents in minutes with Patsnap Eureka AI!

A tadpole-shaped hollow polymer particle and its preparation method and application

A polymer and hollow technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of high cost, cumbersome process steps, low yield, etc., and achieve low environmental pollution, simple process, low cost effect

Active Publication Date: 2022-04-05
国科广化精细化工孵化器(南雄)有限公司 +4
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods for preparing tadpole-shaped polymer particles have complex processes and cumbersome steps, or have low yields and high costs, or the size of tadpole-shaped polymer particles is small and the shape is not clear.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A tadpole-shaped hollow polymer particle and its preparation method and application
  • A tadpole-shaped hollow polymer particle and its preparation method and application
  • A tadpole-shaped hollow polymer particle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 (the mass ratio of polystyrene seed microspheres to styrene and divinylbenzene is 5.0%)

[0066] (1) Weigh 0.7500g of polyvinylpyrrolidone (PVP, molecular weight 58000) into a 100mL two-necked round bottom flask, add 33mL of absolute ethanol and 5mL of toluene, stir evenly, and then add 0.1500g of polystyrene seed microspheres (diameter 2.0± 0.5 μm) to obtain a suspension of polystyrene seed microspheres in a mixed solvent of ethanol and toluene dissolved with polyvinylpyrrolidone;

[0067] (2) Weigh 0.0384g azobisisobutyronitrile (AIBN) into a 25mL single-neck round bottom flask, add 0.3600g divinylbenzene (DVB), 2.6400g styrene (Styrene), 10mL absolute ethanol and 2mL toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0068] (3) Under mechanical stirring conditions (250 rpm) and nitrogen atmosphere (passing nitrogen for 1 h), the polystyrene seed microspheres obtained in step (1) were placed in a mixed solvent of ethanol and toluen...

Embodiment 2

[0071] Embodiment 2 (the mass ratio of polystyrene seed microspheres to styrene and divinylbenzene is 10.0%)

[0072] 1) Weigh 0.7500g polyvinylpyrrolidone (PVP, molecular weight 58000) into a 100mL two-necked round bottom flask, add 33mL absolute ethanol and 5mL toluene, stir well, and then add 0.3000g polystyrene seed microspheres (diameter 2.0±0.5 μm) to obtain a suspension of polystyrene seed microspheres in a mixed solvent of ethanol and toluene dissolved with polyvinylpyrrolidone;

[0073] (2) Weigh 0.0384g azobisisobutyronitrile (AIBN) into a 25mL single-neck round bottom flask, add 0.3600g divinylbenzene (DVB), 2.6400g styrene (Styrene), 10mL absolute ethanol and 2mL toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0074] (3) Under the condition of mechanical stirring (250rpm) and nitrogen atmosphere (passing nitrogen for 1h), the polystyrene seed microspheres obtained in step (1) were mixed with ethanol and toluene (dissolved with polyviny...

Embodiment 3

[0077] Embodiment 3 (the mass ratio of polystyrene seed microspheres to styrene and divinylbenzene is 15.0%)

[0078]1) Weigh 0.7500g polyvinylpyrrolidone (PVP, molecular weight 58000) into a 100mL two-necked round bottom flask, add 33mL absolute ethanol and 5mL toluene, stir well, and then add 0.4500g polystyrene seed microspheres (diameter 2.0±0.5 μm) to obtain a suspension of polystyrene seed microspheres in a mixed solvent of ethanol and toluene dissolved with polyvinylpyrrolidone;

[0079] (2) Weigh 0.0384g azobisisobutyronitrile (AIBN) into a 25mL single-neck round bottom flask, add 0.3600g divinylbenzene (DVB), 2.6400g styrene (Styrene), 10mL absolute ethanol and 2mL toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0080] (3) Under the condition of mechanical stirring (250rpm) and nitrogen atmosphere (passing nitrogen for 1h), the polystyrene seed microspheres obtained in step (1) were mixed with ethanol and toluene (dissolved with polyvinyl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
sizeaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a tadpole-shaped hollow polymer particle, a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving the stabilizer in a mixed solvent of ethanol and toluene, and then adding polystyrene seed microspheres to obtain a suspension; (2) dissolving styrene, divinylbenzene and an initiator In a mixed solvent of ethanol and toluene, the mixed solution of the precursor is obtained; (3) the mixed solution in step (1) is heated to 75±1°C under an inert gas atmosphere, and then the mixed solution obtained in step (2) is heated to 75±1° C. using a peristaltic pump. The mixed solution of the precursor is added dropwise to the suspension in step (1) to carry out the dispersion polymerization reaction. After the reaction is completed, it is cooled to room temperature, centrifuged, washed, and freeze-dried to obtain tadpole-shaped hollow polymer particles. The method of the invention has simple process, little environmental pollution, low cost and high yield, and the prepared tadpole-shaped hollow polymer particles have a hollow structure and can be adjusted in appearance, and have broad application prospects.

Description

technical field [0001] The invention relates to the technical field of polymer particles, in particular to a tadpole-shaped hollow polymer particle and a preparation method and application thereof. Background technique [0002] A tadpole-shaped structure is a unique geometric shape of a structure with two parts, a head and a tail. Organisms with tadpole-shaped structures in nature include tadpoles, sperm cells, bacteria and bacteriophages, etc. The tadpole-shaped structures endow them with unique biological functions. Inspired by the tadpole-shaped structure of organisms in nature, researchers prepared various tadpole-shaped nanoparticles, mainly including tadpole-shaped metal nanoparticles (Hu Jianqiang, Zhang Yong, Liu Bo, Liu Jinxuan, Zhou Haihui, Xu Yunfeng, Jiang Yuxiong, Yang Zhilin, Tian Zhong-Qun, J.Am.Chem.Soc., 2004, 126, 9470-9471; Camargo Pedro H.C., Xiong Yujie, Ji Li, Zuo Jian M., Xia Younan, J.Am. Chem. Soc., 2007, 129, 15452-15453; Yamada Liliam K., da Silv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08F257/02C08F212/08C08F212/36C08J9/00C08L51/00A61K47/32A61K45/00A61P35/00
CPCC08F257/02C08J9/00A61K47/32A61K45/00A61P35/00C08J2351/00C08F212/08C08F212/36
Inventor 胡继文李志华李诗林树东涂园园黄振祝
Owner 国科广化精细化工孵化器(南雄)有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com