Check patentability & draft patents in minutes with Patsnap Eureka AI!

Tadpole-shaped hollow polymer particles as well as preparation method and application thereof

A polymer and hollow technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and inactive medical preparations, can solve the problems of high cost, low yield, cumbersome process steps, etc., and achieves low environmental pollution, low cost, simple craftsmanship

Active Publication Date: 2021-03-12
国科广化精细化工孵化器(南雄)有限公司 +4
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods for preparing tadpole-shaped polymer particles have complex processes and cumbersome steps, or have low yields and high costs, or the size of tadpole-shaped polymer particles is small and the shape is not clear.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tadpole-shaped hollow polymer particles as well as preparation method and application thereof
  • Tadpole-shaped hollow polymer particles as well as preparation method and application thereof
  • Tadpole-shaped hollow polymer particles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1 (the mass ratio of polystyrene seed microsphere and styrene and divinylbenzene is 5.0%)

[0066] (1) Weigh 0.7500g polyvinylpyrrolidone (PVP, molecular weight 58000) in a 100mL two-necked round-bottomed flask, add 33mL absolute ethanol and 5mL toluene, stir well, then add 0.1500g polystyrene seed microspheres (diameter 2.0± 0.5 μm), obtain the suspension of polystyrene seed microsphere in the ethanol that is dissolved with polyvinylpyrrolidone and the mixed solvent of toluene;

[0067] (2) Weigh 0.0384g of azobisisobutyronitrile (AIBN) into a 25mL single-necked round bottom flask, add 0.3600g of divinylbenzene (DVB), 2.6400g of styrene (Styrene), 10mL of absolute ethanol and 2mL of toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0068] (3) Under mechanical stirring conditions (250rpm) and nitrogen atmosphere (through 1h nitrogen), the polystyrene seed microspheres obtained in step (1) were dissolved in a mixed solvent of ethano...

Embodiment 2

[0071] Embodiment 2 (the mass ratio of polystyrene seed microsphere and styrene and divinylbenzene is 10.0%)

[0072] 1) Weigh 0.7500g of polyvinylpyrrolidone (PVP, molecular weight 58000) into a 100mL two-neck round-bottomed flask, add 33mL of absolute ethanol and 5mL of toluene, stir well, then add 0.3000g of polystyrene seed microspheres (diameter 2.0±0.5 μm), obtaining the suspension of polystyrene seed microspheres in ethanol and toluene mixed solvent dissolved with polyvinylpyrrolidone;

[0073] (2) Weigh 0.0384g of azobisisobutyronitrile (AIBN) into a 25mL single-necked round bottom flask, add 0.3600g of divinylbenzene (DVB), 2.6400g of styrene (Styrene), 10mL of absolute ethanol and 2mL of toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0074] (3) Under the conditions of mechanical stirring (250rpm) and nitrogen atmosphere (passing 1h nitrogen), the polystyrene seed microspheres obtained in step (1) were dissolved in a mixed solvent of eth...

Embodiment 3

[0077] Embodiment 3 (the mass ratio of polystyrene seed microsphere and styrene and divinylbenzene is 15.0%)

[0078]1) Weigh 0.7500g polyvinylpyrrolidone (PVP, molecular weight 58000) into a 100mL two-necked round bottom flask, add 33mL absolute ethanol and 5mL toluene, stir well, then add 0.4500g polystyrene seed microspheres (diameter 2.0±0.5 μm), obtaining the suspension of polystyrene seed microspheres in ethanol and toluene mixed solvent dissolved with polyvinylpyrrolidone;

[0079] (2) Weigh 0.0384g of azobisisobutyronitrile (AIBN) into a 25mL single-necked round bottom flask, add 0.3600g of divinylbenzene (DVB), 2.6400g of styrene (Styrene), 10mL of absolute ethanol and 2mL of toluene, Use a magnet to stir evenly to obtain a precursor mixed solution;

[0080] (3) Under the conditions of mechanical stirring (250rpm) and nitrogen atmosphere (passing 1h nitrogen), the polystyrene seed microspheres obtained in step (1) were dissolved in a mixed solvent of ethanol and tolu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses tadpole-shaped hollow polymer particles as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving a stabilizer in a mixed solvent of ethanol and toluene, and adding polystyrene seed microspheres to obtain a suspension; (2) dissolving styrene, divinylbenzene and an initiator in the mixed solvent of ethanol and toluene to obtain a precursor mixed solution; and (3) heating the suspension obtained in the step (1) to 75 + / -1 DEG C in an inert gas atmosphere, then dropwise adding the precursor mixed solutionobtained in the step (2) into the suspension obtained in the step (1) by using a peristaltic pump for dispersion polymerization reaction, cooling to room temperature after the reaction is finished, centrifuging, washing and freeze-drying to obtain tadpole-shaped hollow polymer particles. The method is simple in process, small in environmental pollution, low in cost and high in yield, and the prepared tadpole-shaped hollow polymer particles are of hollow structures, controllable in morphology and wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of polymer particles, in particular to a tadpole-shaped hollow polymer particle and a preparation method and application thereof. Background technique [0002] A tadpole-shaped structure is a structurally unique geometric shape with two parts, a head and a tail. Organisms with tadpole-shaped structures in nature include tadpoles, sperm cells, bacteria and phages, etc. The tadpole-shaped structures endow them with unique biological functions. Inspired by the tadpole-shaped structure of organisms in nature, researchers have prepared various tadpole-shaped nanoparticles, mainly including tadpole-shaped metal nanoparticles (Hu Jianqiang, Zhang Yong, Liu Bo, Liu Jinxuan, Zhou Haihui, Xu Yunfeng, Jiang Yuxiong, Yang Zhilin, Tian Zhong-Qun, J.Am.Chem.Soc., 2004, 126, 9470-9471; Camargo Pedro H.C., Xiong Yujie, Ji Li, Zuo Jian M., Xia Younan, J.Am. Chem.Soc., 2007, 129, 15452-15453; Yamada Liliam K., da Silva Ande...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08F257/02C08F212/08C08F212/36C08J9/00C08L51/00A61K47/32A61K45/00A61P35/00
CPCC08F257/02C08J9/00A61K47/32A61K45/00A61P35/00C08J2351/00C08F212/08C08F212/36
Inventor 胡继文李志华李诗林树东涂园园黄振祝
Owner 国科广化精细化工孵化器(南雄)有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com