X-ray near-infrared two-region light-emitting biological imaging device

Abstract

The invention discloses an X-ray near-infrared two-region light-emitting biological imaging device. The device comprises a light source module and a light-emitting imaging module. The light-emitting imaging module comprises an objective lens, a first dichroscope, a CCD camera and an InGaAs camera. The light source module is used for providing exciting light for a to-be-imaged sample, the objectivelens is used for collecting fluorescence emitted after the to-be-imaged sample is excited, and the first dichroscope is used for reflecting the fluorescence collected by the objective lens to a lightinlet of the CCD camera or the InGaAs camera. According to the scheme, through cooperative switching of the X-ray excitation light path and the imaging camera, X-ray visible near-infrared two-regionlight-emitting imaging can be achieved conveniently, then instrument support can be provided for scintillator material and X-ray light-emitting analysis research, complex sample in-vitro diagnosis anddeep living body precise imaging analysis can be achieved easily, and research and development of scintillator nano materials and leading scientific research and practical application of the scintillator nano materials in the fields of X-ray luminescence immunoassay, X-ray luminescence imaging, X-ray treatment, X-ray optogenetics research and the like are promoted.

Description

technical field [0001] The invention relates to the technical field of X-ray luminescence imaging, in particular to an X-ray near-infrared two-zone luminescence biological imaging device. Background technique [0002] The luminescence of scintillator materials excited by X-rays (X-ray luminescence) is a phenomenon in which scintillator materials absorb high-energy X-rays and convert them into low-energy photons (such as visible light, near-infrared light, etc.). [0003] In recent years, X-ray luminescence analysis technology based on scintillator nanoparticles has developed into a new method and new technology of optical analysis in biomedical research. As a type of high-energy photons, X-rays have a strong penetrating ability to living tissues. X-ray luminescence imaging technology can effectively eliminate the interference of background fluorescence in luminescent imaging of blood samples and living tissues, and has a high imaging signal. noise ratio. X-ray immunoassay,...

AI Technical Summary

Problems solved by technology

However, the CCD camera configured in the current commercial X-ray small animal imager has problems such as low sensitivity, single imaging function, and small response band (400-800nm), and can only be used for visible-near-infrared luminescent imaging. The blank status of commercial X-ray near-infrared two-zone luminescence imager greatly limits the application and innovation research of scintillator nanomaterials in vitro precise diagnosis and in vivo high-sensitivity and high-resolution imaging.

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