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1, 7-diphenyl-4-heptene-3-ketone separated from galangal and application of 1, 7-diphenyl-4-heptene-3-ketone

A technology of diphenyl and galangal, which is applied in the separation/purification of carbonyl compounds, active ingredients of ketones, food science, etc., can solve problems such as deficiency, and achieve the improvement of glucose tolerance, the decrease of random blood sugar level, and the improvement of IR effect. Effect

Inactive Publication Date: 2021-03-26
HAINAN MEDICAL COLLEGE
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Problems solved by technology

However, the current report lacks more in-depth research, and cannot well determine the specific impact of 1,7-diphenyl-4-hepten-3-one isolated and extracted from galangal on diabetes

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  • 1, 7-diphenyl-4-heptene-3-ketone separated from galangal and application of 1, 7-diphenyl-4-heptene-3-ketone
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  • 1, 7-diphenyl-4-heptene-3-ketone separated from galangal and application of 1, 7-diphenyl-4-heptene-3-ketone

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Embodiment Construction

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0028] A kind of 1,7-diphenyl-4-hepten-3-one isolated in galanga, the separation method comprises the following steps:

[0029] Galangal extract extraction: 42kg of galangal is pulverized, 80% ethanol is heated and refluxed 3 times, each time for 2h, the ratio of solid to liquid is 1:10, and the combined filtrate is concentrated to 10L to obtain; separation and purification: a small amount of galangal extract is placed in a separatory bottle In the solution, a...

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Abstract

The invention discloses 1, 7-diphenyl-4-heptene-3-ketone separated from galangal and an application thereof. The separation method comprises the following steps that 42 kg of galangal is smashed, 80%ethyl alcohol is heated and refluxed three times, supernatant liquid and subnatant liquid are taken respectively to be dripped on a plate, and extraction is completed if the subnatant liquid is not dripped on the plate and the subnatant liquid drips out slightly; after the extraction is finished, the supernatant is taken, combining is carried out, and rotary evaporation and volatilizing are carried out to obtain a galangal extract; the extract is loaded on a column according to a ratio of 1: 7, 385g of silica gel and 55g of a silica gel protection column are carried out, fractions obtained bywashing petroleum ether, ethyl acetate, methanol and water according to eluent ratios of (30: 1), (25: 1), (20: 1), (15: 1), (10: 1), (5: 1) and (5: 3) are respectively connected, and a liquid phase is prepared. The galangal extract has a remarkable IR improving effect, and the compound can up-regulate the transcription level of Nrf2 mRNA and downstream target genes.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to 1,7-diphenyl-4-hepten-3-one isolated from galanga and its application. Background technique [0002] Galangal is the dry rhizome of Alpinia officinarum Hance, a plant of the ginger family Zingiberaceae. It has the effects of warming the middle and dispelling cold, warming and relieving pain, harmonizing the stomach, and promoting qi and guiding stagnation. It is often used clinically to treat abdominal cold pain , stomach cold vomiting and other symptoms. Chemical studies have shown that galangal mainly contains flavonoids, volatile oils and diphenylheptane compounds. Pharmacological studies have found that it has various pharmacological effects such as anti-diabetes, anti-ulcer, anti-emetic, and anti-inflammatory. It has been reported that galangal extract has a significant hypoglycemic effect. Domestic studies have also reported that galangal extract and diphenylhe...

Claims

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Application Information

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IPC IPC(8): C07C45/78C07C49/223A61K31/12A61P3/06A61P3/10A61P19/06A61P3/04A61P3/00A61P9/00
CPCC07C45/78A23L33/10A61K31/12A61P3/06A61P3/10A61P19/06A61P3/04A61P3/00A61P9/00A23V2002/00
Inventor 张俊清赖伟勇谢振蕊周明艳刘爱霞李湘怡李丽张钰昕
Owner HAINAN MEDICAL COLLEGE
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