Medicine for resisting inflammation, easing pain and stopping bleeding and medicine active component screening method

Abstract

The invention discloses a medicine for resisting inflammation, easing pain and stopping bleeding and a medicine active component screening method. The medicine comprises the following components: 300-500 parts of kaempferol, 1-5 parts of robinin, 8-20 parts of quercetin, 30-60 parts of baicalein and 10-20 parts of wogonin. The screening method comprises the following steps: screening active compounds from main chemical components in scutellaria baicalensis and sophora japonica; collecting a protein target of the active compound, retrieving and correcting to obtain a gene name, and establishinga dysfunctional uterine bleeding target set; obtaining an intersection gene of the active compound and a dysfunctional uterine bleeding target, carrying out pathway enrichment analysis on the intersection gene, and screening to obtain the active compound. The medicine is good in curative effect and can be more effectively used for resisting inflammation, easing pain and stopping bleeding.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a screening method for a drug and its active component, in particular to a screening method for a drug for anti-inflammation, analgesia and hemostasis and the active component of the drug. Background technique [0002] Dysfunctional uterine bleeding (DUB) is a common disease type in gynecological clinical treatment. DUB is caused by neuroendocrine disorders, not by systemic or organic diseases of the female genital tract such as pregnancy, endometrial tumors, infections, or blood diseases. Often occurs in adolescence or perimenopause, mostly anovulatory DUB. The causes of anovulatory DUB are different during puberty and menopause. DUB in adolescence is mostly due to immature or delayed development of the hypothalamus-pituitary-ovary axis, and a perfect feedback regulation mechanism has not been established between the hypothalamus-pituitary and ovary. Under the action of pituitar...

AI Technical Summary

Problems solved by technology

[0003] Due to the complex composition of traditional Chinese medicine, its active ingredients are not easy to determine. In order to ensure the efficacy of the medicine, the form of decoction is often used to take the active ingredients and other non-effective ingredients together. The dosage is large. For the same reason, due to the drug loading limitations and cannot be developed into modern dosage forms

Moreover, the current process route and quality control of traditional Chinese medicine mostly use chemical components as indicators, but the correlation between these components and clinical safety and effectiveness is not clear, which may affect the efficacy of drugs to a certain extent

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