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CT imaging contrast medium for gastrointestinal tract and preparation method therefor

A technology of contrast agent and gastrointestinal tract, which is applied in the direction of X-ray contrast agent preparation, etc. It can solve the problems of poor solubility of barium sulfate contrast agent, insufficient filling of gastrointestinal tract, long preparation time of gastrointestinal tract, etc., and achieve good biophase Capacitive, uniform shape, good dispersion effect

Pending Publication Date: 2021-04-02
GREENVIKIBEIJING BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most domestic hospitals use barium sulfate (ie barium meal) and iodine compounds as gastrointestinal contrast agents, but there are problems such as poor taste, insufficient filling of gastrointestinal tract, and long preparation time of gastrointestinal tract in clinical use.
In addition, the compounds of barium sulfate and iodine do not absorb X-rays strongly, and the enhancement is poor. If the contrast agent concentration is increased
Barium sulfate contrast medium has poor solubility and is not suitable for patients with gastrointestinal perforation, and the use of large doses of iodine contrast medium can cause iodine allergic reactions and other problems

Method used

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  • CT imaging contrast medium for gastrointestinal tract and preparation method therefor
  • CT imaging contrast medium for gastrointestinal tract and preparation method therefor
  • CT imaging contrast medium for gastrointestinal tract and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0036] (1) Weigh 0.2g of bismuth nitrate pentahydrate solid powder in a beaker, add 23mL of ethylene glycol solution to dissolve, and obtain solution A;

[0037] (2) Weigh 0.1 g of polyvinylpyrrolidone, add 5 mL of secondary water to dissolve, then add to solution A to obtain solution B;

[0038] (3) Weigh 0.3 g of thioacetamide, add 2 mL of secondary water to dissolve, add to solution B, stir for about half an hour, and obtain solution C;

[0039] (4) The solution C was transferred to a reaction kettle for solvothermal reaction, the reaction temperature was 160° C., and the reaction time was 6 h.

[0040] (5) After the reaction, the reaction product was washed several times with secondary water and absolute ethanol, and then freeze-dried to obtain the final product with a size of about 50 nm.

Embodiment example 2

[0042] (1) Weigh 0.5g of bismuth acetate in a beaker, add 18mL of ethylene glycol solution to dissolve, and obtain solution A;

[0043] (2) Weigh 0.1 g of polyethylene glycol, add 5 mL of secondary water to dissolve, then add to solution A to obtain solution B;

[0044] (3) Weigh 0.3g of sulfur powder, add 2mL of ethylene glycol to dissolve, add to solution B, stir for about half an hour, and obtain solution C;

[0045] (4) The solution C was transferred to a reaction kettle for solvothermal reaction, the reaction temperature was 180° C., and the reaction time was 12 hours.

[0046](5) After the reaction, wash the reaction product several times with distilled water and absolute ethanol, and then freeze-dry to obtain the final product with a size of about 80 nm.

Embodiment example 3

[0048] (1) Take by weighing 0.2g of bismuth nitrate pentahydrate solid powder in a beaker, add 20mL of secondary water to dissolve, and obtain solution A;

[0049] (2) Weigh 0.1 g of polyacrylic acid, add 5 mL of secondary water to dissolve it, and then add it to solution A to obtain solution B;

[0050] (3) Weigh 0.3 g of thioacetamide, add 5 mL of absolute ethanol to dissolve it, add it to solution B, and stir for about half an hour to obtain solution C;

[0051] (4) The solution C was transferred to a reaction kettle for solvothermal reaction, the reaction temperature was 180° C., and the reaction time was 24 hours.

[0052] (5) After the reaction, wash the reaction product several times with distilled water and absolute ethanol, and then freeze-dry to obtain the final product with a size of about 50 nm.

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Abstract

The invention discloses a CT imaging contrast medium with relatively high chemical stability and relatively good CT visualization effect and biocompatibility and a preparation method therefor. The technical scheme of the invention is as follows: Bi2S3 nanoparticles with different particle sizes and chemical-modified surfaces prepared from a bismuth source and a sulfur source under solvothermal conditions serve as the CT contrast medium.

Description

technical field [0001] A CT gastrointestinal contrast agent relates to a gastrointestinal contrast agent used in clinical application of a CT machine. Background technique [0002] X-ray computed tomography (X-ray computed tomography, CT) refers to a non-invasive imaging in which the X-ray beam scans around a certain layer of the human body, measures the absorption coefficient of each unit volume in this layer, and then reconstructs it with a computer. technology. CT examination is fast, simple and completely painless, and is widely used in clinical practice. In the abdominal examination, the CT examination of the upper abdomen advocates the use of water as a contrast agent. Since the difference in the absorption of X-rays between the middle and lower abdomen and the pelvis is very small, the CT examination needs to use a positive contrast agent to fill the gastrointestinal tract and improve the absorption of X-rays. The difference makes the display of images more clear an...

Claims

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Application Information

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IPC IPC(8): A61K49/04
CPCA61K49/04
Inventor 钱伟
Owner GREENVIKIBEIJING BIOLOGICAL TECH CO LTD
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